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    HUMANIZED C5 AND C3 ANIMALS
    1.
    发明申请
    HUMANIZED C5 AND C3 ANIMALS 审中-公开
    人造C5和C3动物

    公开(公告)号：WO2015171523A1

    公开(公告)日：2015-11-12

    申请号：PCT/US2015/029111

    申请日：2015-05-04

    Applicant: REGENERON PHARMACEUTICALS, INC.

    Inventor： HU, Ying ,  LATUSZEK, Adriana ,  CAO, Jingtai ,  MUJICA, Alexander ,  WIEGAND, Stanley ,  MCWHIRTER, John ,  MURPHY, Andrew ,  MACDONALD, Lynn

    IPC: A01K67/027 ,  A61K49/00 ,  C07K14/47 ,  C12N15/85

    CPC classification number: A01K67/0278 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/03 ,  A01K2267/0368 ,  A61K49/0008 ,  C07K14/472

    Abstract: Non-human animals comprising a human or humanized C3 and/or C5 nucleic acid sequence are provided as well as methods for using the same to identify compounds capable of modulating the complement system. Non-human animals that comprise a replacement of the endogenous C5 gene and/or C3 gene with a human or humanized C5 gene and/or C3 gene, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized C5 gene under control of non-human C5 regulatory elements is also provided, including non-human animals that have a replacement of non-human C5-encoding sequence with human C5-encoding sequence at an endogenous non-human C5 locus. Non-human animals comprising a human or humanized C3 gene under control of non-human C3 regulatory elements is also provided, including non-human animals that have a replacement of non-human C3 protein-encoding sequence with human or humanized C3 protein-encoding sequence at an endogenous non-human C3 locus. Non-human animals comprising human or humanized C3 and/or C5 sequences, wherein the non-human animals are rodents, e.g., mice or rats, are provided.

    Abstract translation: 提供了包含人或人源化C3和/或C5核酸序列的非人动物以及使用其来鉴定能够调节补体系统的化合物的方法。 描述了包含用人或人源化C5基因和/或C3基因替代内源性C5基因和/或C3基因的非人动物，以及制备和使用非人动物的方法。 还提供了包含非人C5调控元件控制下的人或人源化C5基因的非人动物，包括非人类动物，其以内源性的人C5编码序列替代人C5编码序列 非人C5位点。 还提供了包含非人C3调控元件控制下的人或人源化C3基因的非人动物，包括用人或人源化C3蛋白编码替代非人C3蛋白编码序列的非人动物 在内源性非人C3位点的序列。 提供包含人或人源化C3和/或C5序列的非人动物，其中非人类动物是啮齿动物，例如小鼠或大鼠。

    HUMANIZED DIPEPTIDYL PEPTIDASE IV (DPP4) ANIMALS
    3.
    发明申请
    HUMANIZED DIPEPTIDYL PEPTIDASE IV (DPP4) ANIMALS 审中-公开
    人类皮肤肽肽IV（DPP4）动物

    公开(公告)号：WO2015184164A1

    公开(公告)日：2015-12-03

    申请号：PCT/US2015/033024

    申请日：2015-05-28

    Applicant: REGENERON PHARMACEUTICALS, INC.

    Inventor： KYRATSOUS, Christos ,  MUJICA, Alexander

    IPC: A01K67/027

    CPC classification number: A01K67/0278 ,  A01K67/0276 ,  A01K2207/15 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/03 ,  A01K2267/0337 ,  C12Q1/68 ,  C12Q1/6883 ,  C12Q1/70 ,  C12Y304/14005 ,  G01N33/56983

    Abstract: Non-human animals comprising a human or humanized DPP4 nucleic acid sequence are provided. Non-human animals that comprise a replacement of the endogenous Dpp4 gene with a human or humanized DPP4 gene, or non-human animals comprising a human or humanized DPP4 gene in addition to the endogenous Dpp4 gene are described. Non-human animals comprising a human or humanized DPP4 gene under control of human or non-human DPP4 regulatory elements is also provided, including non-human animals that have a replacement of non-human Dpp4 -encoding sequence with human DPP4 -encoding sequence at an endogenous non-human Dpp4 locus. Non-human animals comprising human or humanized DPP4 gene sequences, wherein the non-human animals are rodents, e.g., mice or rats, are provided. Methods for making and using the non-human animals are described.

    Abstract translation: 提供了包含人或人源化DPP4核酸序列的非人动物。 描述了包含人源或人源化DPP4基因的内源性Dpp4基因替换的非人动物，或除内源Dpp4基因之外包含人或人源化DPP4基因的非人动物。 还提供了包含在人或非人DPP4调节元件控制下的人或人源化DPP4基因的非人动物，包括非人动物，其具有用人DPP4编码序列替代非人Dpp4编码序列 内源性非人Dpp4基因座。 提供包含人或人源化DPP4基因序列的非人动物，其中非人动物是啮齿动物，例如小鼠或大鼠。 描述了制造和使用非人类动物的方法。

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