公开(公告)号：WO2006020616A1

公开(公告)日：2006-02-23

申请号：PCT/US2005/028228

申请日：2005-08-09

Applicant: REVA MEDICAL, INC. ,  BRANDOM, Donald, K. ,  ZELTINGER, Joan

Inventor： BRANDOM, Donald, K. ,  ZELTINGER, Joan

IPC: C08G64/12

CPC classification number: C08G65/4006 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2002/91591 ,  A61F2210/0004 ,  A61K49/0442 ,  A61L31/18 ,  B33Y70/00 ,  B33Y80/00 ,  C08G64/08 ,  C08G64/18

Abstract: Preferred embodiments of the present invention relate to polymeric medical devices, such as stents. More particularly, the compositions disclosed herein comprise halogen-containing phenol moeities, that may be used for medical devices and other uses whereby bioresorbable and radiopaque and physicomechanical properties are desired.

Abstract translation: 本发明的优选实施方案涉及聚合物医疗装置，例如支架。 更具体地，本文公开的组合物包含含卤素的苯酚，其可用于医疗器械和其它需要生物可再吸收和不透射线和物理机械性能的用途。

公开(公告)号：WO2006086069A2

公开(公告)日：2006-08-17

申请号：PCT/US2005/045553

申请日：2005-12-15

Applicant: REVA MEDICAL, INC. ,  SCHMID, Eric, V. ,  NGUYEN, John, D. ,  HOWARD, Steven, C. ,  PADILLA, Orlando, M. ,  MORRIS, Andrew ,  EISELE, Robert, F. ,  DIPARI, Joseph, Anthony ,  MATSUURA, David, G. ,  SIMPSON, Philip, J. ,  GILLESPIE, Walter, D. ,  MOORE, Daniel ,  JACKSON, Thomas, R. ,  ZELTINGER, Joan ,  ESSER, Keith, Allen ,  BRANDOM, Donald, K.

Inventor： SCHMID, Eric, V. ,  NGUYEN, John, D. ,  HOWARD, Steven, C. ,  PADILLA, Orlando, M. ,  MORRIS, Andrew ,  EISELE, Robert, F. ,  DIPARI, Joseph, Anthony ,  MATSUURA, David, G. ,  SIMPSON, Philip, J. ,  GILLESPIE, Walter, D. ,  MOORE, Daniel ,  JACKSON, Thomas, R. ,  ZELTINGER, Joan ,  ESSER, Keith, Allen ,  BRANDOM, Donald, K.

IPC: A61F2/06

CPC classification number: A61F2/82 ,  A61F2/92 ,  A61F2/93 ,  A61F2210/0076 ,  A61F2220/005 ,  A61F2220/0058 ,  B33Y80/00

Abstract: The invention relates to an expandable stent (10) comprising circumferentially adjacent modules (12). The modules (12) comprise longitudinally adjacent slide-and-lock radial elements (14, 16) which permit one-way sliding of the radial elements from a collapsed diameter to an expanded/deployed diameter, but inhibit radial recoil from the expanded diameter.

Abstract translation: 本发明涉及一种包括周向相邻模块（12）的可扩张支架（10）。 模块（12）包括纵向相邻的滑动和锁定径向元件（14,16），其允许径向元件从塌缩直径单向滑动到扩张/展开的直径，但是抑制从扩张直径的径向反冲。

公开(公告)号：WO2007084444A2

公开(公告)日：2007-07-26

申请号：PCT/US2007/001011

申请日：2007-01-16

Applicant: REVA MEDICAL INC. ,  BRANDOM, Donald K. ,  MCGRATH, James E. ,  ZELTINGER, Joan ,  SCHMID, Eric V. ,  SCHULTZ, Robert K.

Inventor： BRANDOM, Donald K. ,  MCGRATH, James E. ,  ZELTINGER, Joan ,  SCHMID, Eric V. ,  SCHULTZ, Robert K.

IPC: A61L31/06 ,  A61L31/18

CPC classification number: A61L31/18 ,  A61F2/92 ,  A61K49/12 ,  A61K49/126 ,  A61K49/128 ,  A61L31/06 ,  C08F220/00 ,  C08G63/00 ,  C08G63/08

Abstract: Side-chain crystallizable (SCC) polymers are useful in various medical applications. In certain applications, heavy atom containing side-chain crystallizable polymers (HACSCCP's) are particularly useful. An example of a HACSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer. In certain configurations, the heavy atoms are present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes an HACSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product. A polymeric material that includes a SCC polymer may also be fabricated into other medical devices, such as stents.

Abstract translation: 侧链可结晶（SCC）聚合物可用于各种医疗应用。 在某些应用中，含重链原子的侧链可结晶聚合物（HACSCCP）尤其有用。 HACSCCP的实例是包含主链，多个可结晶侧链和连接到聚合物上的多个重原子的聚合物。 在某些构型中，重质原子以有效使聚合物不透射线的量存在。 包括HACSCCP的聚合物材料可以被制造成用于至少部分地封闭体腔的医疗装置。 例如，这样的医疗装置可以是电疗产品。 包括SCC聚合物的聚合物材料也可制成其他医疗装置，例如支架。

公开(公告)号：WO2006014596A1

公开(公告)日：2006-02-09

申请号：PCT/US2005/024289

申请日：2005-07-07

Applicant: REVA MEDICAL, INC. ,  BRANDOM, Donald, K. ,  ZELTINGER, Joan ,  SCHMID, Eric, V. ,  MCGRATH, James, E. ,  MALLON, Joseph, J.

Inventor： BRANDOM, Donald, K. ,  ZELTINGER, Joan ,  SCHMID, Eric, V. ,  MCGRATH, James, E. ,  MALLON, Joseph, J.

IPC: C08G64/12

CPC classification number: C08G64/10 ,  A61B17/12022 ,  A61B17/12036 ,  A61B17/12145 ,  A61B17/12186 ,  A61K31/74 ,  A61K33/18 ,  A61K45/06 ,  A61K49/0442 ,  A61K49/0476 ,  A61L24/0042 ,  A61L31/148 ,  A61L31/18 ,  C08F220/18 ,  C08G63/68 ,  C08G63/6826 ,  C08G63/6856 ,  C08G63/6886 ,  C08G63/916 ,  C08G64/12 ,  C08G64/42 ,  C08G65/40 ,  C08G77/24 ,  C08G2261/126 ,  A61K2300/00

Abstract: Inherently radiopaque side-chain crystallizable polymers (IRSCCP's) are useful in various medical applications. An example of a IRSCCP is a polymer that comprises a main chain, a plurality of crystallizable side chains, and a plurality of heavy atoms attached to the polymer, the heavy atoms being present in an amount that is effective to render the polymer radiopaque. A polymeric material that includes a IRSCCP may be fabricated into a medical device useful for at least partially occluding a body cavity. For example, such a medical device may be an embolotherapy product.

Abstract translation: 固有的不透射线的侧链可结晶聚合物（IRSCCP）可用于各种医疗应用。 IRSCCP的实例是包含主链，多个可结晶侧链和连接到聚合物上的多个重原子的聚合物，重原子以有效使聚合物不透射线的量存在。 包括IRSCCP的聚合物材料可以制造成用于至少部分地封闭体腔的医疗装置。 例如，这种医疗装置可以是电疗产品。

公开(公告)号：WO2005030268A1

公开(公告)日：2005-04-07

申请号：PCT/US2004/031770

申请日：2004-09-27

Applicant: RUTGERS, THE STATE UNIVERSITY ,  BRANDOM, Donald, K. ,  SCHMID, Eric ,  ZELTINGER, Joan ,  KOHN, Joachim, B. ,  BOLIKAL, Durgadas

Inventor： BRANDOM, Donald, K. ,  SCHMID, Eric ,  ZELTINGER, Joan ,  KOHN, Joachim, B. ,  BOLIKAL, Durgadas

IPC: A61K51/00

CPC classification number: A61K31/785 ,  A61K49/0442

Abstract: Preferred embodiments relate to compositions of inherently radiopaque, biocompatible, bioresorbable polymeric particles and methods of using them for embolizing a body lumen.

Abstract translation: 优选的实施方案涉及固有的不透射线的，生物相容的，生物可再吸收的聚合物颗粒的组合物和使用它们来栓塞体腔的方法。

公开(公告)号：WO2006022754A2

公开(公告)日：2006-03-02

申请号：PCT/US2004/031771

申请日：2004-09-27

Applicant: RUTGERS, THE STATE UNIVERSITY ,  KOHN, Joachim, B. ,  BOLIKAL, Durgadas ,  ZELTINGER, Joan ,  PESNELL, Aaron, F. ,  BRANDOM, Donald, K. ,  SCHMID, Eric

Inventor： KOHN, Joachim, B. ,  BOLIKAL, Durgadas ,  ZELTINGER, Joan ,  PESNELL, Aaron, F. ,  BRANDOM, Donald, K. ,  SCHMID, Eric

IPC: A61K49/04 ,  A61M31/00

CPC classification number: A61F2/86 ,  A61K49/0447 ,  A61L31/06 ,  A61L31/148 ,  A61L31/18 ,  C08G63/672 ,  C08G63/6826 ,  C08G64/183 ,  C08L71/02

Abstract: Preferred embodiments of the present invention relate to polymeric medical devices, such as stents. More particularly, the polymeric compositions disclosed herein comprise halogen-containing, tyrosine-derived diphenols, optionally in conjunction with other groups, such as dicarboxylic acids and/or poly(alkylene oxide), such that the medical devices made from these polymeric compositions are bioresorbable and inherently radiopaque, and exhibit physicomechanical properties consistent with the intended uses of such devices.

Abstract translation: 本发明的优选实施方案涉及聚合物医疗装置，例如支架。 更具体地，本文公开的聚合物组合物包含任选与其它基团如二羧酸和/或聚（环氧烷）结合的含卤素的酪氨酸衍生的二酚，使得由这些聚合物组合物制成的医疗装置是生物可再吸收的 并且固有地不透射线，并且表现出与这种装置的预期用途一致的物理机械性质。

公开(公告)号：WO2004021923A2

公开(公告)日：2004-03-18

申请号：PCT/US2003/027531

申请日：2003-09-04

Applicant: REVA MEDICAL, INC. ,  PADILLA, Orlando ,  ESSER, Keith ,  ZELTINGER, Joan

Inventor： PADILLA, Orlando ,  ESSER, Keith ,  ZELTINGER, Joan

IPC: A61F

CPC classification number: A61F2/844 ,  A61F2210/0004 ,  A61F2220/0033 ,  A61F2230/0058 ,  A61F2230/006 ,  A61F2250/006 ,  Y10T29/49995 ,  Y10T29/49996

Abstract: The present invention provides a lumen support prosthesis composed of interlocking radial modules which is fabricated fully assembled from a signal piece shape, without welding or bonding. The prosthesis comprises at least one locking mechanism, allowing for one-way sliding of the radial modules and expansion of the prosthesis from a collapsed state, but inhibits radial recoil from the expanded diameter. The prosthesis may be fabricated from biologically degradable materials which have certain medical advantages.

Abstract translation: 本发明提供了一种由互锁的径向模块组成的管腔支架假体，其由信号片形状完全组装而没有焊接或粘合。 假体包括至少一个锁定机构，允许径向模块的单向滑动和假体从折叠状态的膨胀，但是抑制从扩张的直径的径向反冲。 假体可以由具有某些医学优点的生物降解材料制成。