公开(公告)号：WO2020099663A1

公开(公告)日：2020-05-22

申请号：PCT/EP2019/081546

申请日：2019-11-15

Applicant: S-BIOMEDIC N.V.

Inventor： LOOD, Rolf

IPC: A61P17/00 ,  A61P17/18 ,  A61K35/74 ,  A61K38/16 ,  A61K8/66 ,  A61K8/99 ,  G01N33/50

Abstract: The present application relates to the use of compositions comprising a live C. acnes strain secreting RoxP (radical oxygenase of Propionibacterium acnes ) and compositions comprising RoxP or a biologically active variant or fragment thereof for treating or preventing oxidative stress-associated skin diseases or for preventing or reducing skin ageing. The application further relates to method for diagnosing oxidative stress-associated skin disease in a subject or for determining the benefit a subject would receive from administration of RoxP or a live C. acnes strain secreting RoxP, the methods comprising determining the quantity of RoxP or the quantity of C. acnes in a skin sample from the subject.