公开(公告)号：WO2021257682A1

公开(公告)日：2021-12-23

申请号：PCT/US2021/037599

申请日：2021-06-16

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

Inventor： KAUFFMANN, Aaron ,  STRADINGER, Jon

IPC: B03C1/005 ,  G01N15/06 ,  G01N27/74 ,  G01N33/487 ,  G01N33/50 ,  G01N33/537

Abstract: Analytical assay reaction cartridges, kits containing same, and methods of production and use thereof are disclosed. These cartridges include a magnetic assembly that surrounds at least a portion of a sample read window on the cartridge. The cartridge also includes an analytical reagent positioned therewithin, wherein the analytical reagent comprises magnetic beads coated with at least one anti-red blood cell antibody.

公开(公告)号：WO2020190603A1

公开(公告)日：2020-09-24

申请号：PCT/US2020/022233

申请日：2020-03-12

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

Inventor： KAUFFMANN, Aaron ,  MAYFIELD, Jeffrey ,  LEDDEN, David

IPC: B01L3/00 ,  C12M1/00

Abstract: Microfluidic devices, method for making and using same are disclosed. The microfluidic device can be made by applying a reagent in liquid form into a sample treatment site within a substrate base. The substrate base has hydrophilic properties bordering a flow channel, and has an application site, the sample treatment site and an analytical site. The flow channel is sized and configured so as to draw a sample applied into the application site to the analytical site through the sample treatment site by capillary action. The reagent is freeze-dried within the sample treatment site.

公开(公告)号：WO2020180553A1

公开(公告)日：2020-09-10

申请号：PCT/US2020/019840

申请日：2020-02-26

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

Inventor： KAUFFMANN, Aaron

IPC: C12Q1/00 ,  C12Q1/37 ,  G01N33/72

Abstract: Non-limiting embodiments of a modified solid reagent zone comprising at least hydrophilic polysaccharide and/or at least one hydrophilic non-polysaccharide polymer for use in the conductance of at least one diagnostic assay, as well as kits and methods of use and production related thereto.

公开(公告)号：WO2020180552A1

公开(公告)日：2020-09-10

申请号：PCT/US2020/019835

申请日：2020-02-26

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

Inventor： KAUFFMANN, Aaron ,  LEDDEN, David ,  ZIMMERLE, Chris ,  STRADINGER, Jon

IPC: B01L3/00 ,  G01N33/487

Abstract: Non-limiting embodiments of a modified devices that comprise at least one dye for determining whether results obtained from the conductance of at least one diagnostic assay are biased, as well as kits and methods of use related thereto.

公开(公告)号：WO2020163211A1

公开(公告)日：2020-08-13

申请号：PCT/US2020/016348

申请日：2020-02-03

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

Inventor： KAUFFMANN, Aaron ,  ZIMMERLE, Chris

IPC: A61B5/00 ,  A61B5/145

Abstract: Disclosed herein are methods for rapid detection of suspension of a blood sample from a subject and methods for improving the processing time of a point of care blood analysis. Specifically, the disclosed methods provide a rapid detection of hemoglobin concentration, more specifically glycated hemoglobin A1c, and determination of sugar concentration in the blood sample from the subject. Further disclosed herein are methods for rapidly diagnosing diabetes in a subject.

公开(公告)号：WO2020013970A1

公开(公告)日：2020-01-16

申请号：PCT/US2019/038181

申请日：2019-06-20

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

Inventor： KAUFFMANN, Aaron

IPC: C23C14/32 ,  C23C14/34 ,  C23C14/35

Abstract: Devices, kits, and methods related to embodiments of an improved liquid test sample injection device comprising a sample mixture that comprises at least one sample flag compound for detecting the presence or non-presence of a patient's liquid test sample upon being interrogated by a pre-determined wavelength of light.

公开(公告)号：WO2022066719A1

公开(公告)日：2022-03-31

申请号：PCT/US2021/051485

申请日：2021-09-22

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

Inventor： KAUFFMANN, Aaron ,  DESHPANDE, Manish

IPC: G06K7/00

Abstract: A reagent strip is described. The reagent strip includes a substrate and at least one reagent pad positioned on the substrate. The substrate has a storage unit storing an authentication code. The authentication code has a lot value and a secondary value related to the lot value by a predetermined function assigned to the lot value.

公开(公告)号：WO2022005953A1

公开(公告)日：2022-01-06

申请号：PCT/US2021/039341

申请日：2021-06-28

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

Inventor： KAUFFMANN, Aaron ,  STRADINGER, Jon ,  LEDDEN, David

IPC: A61M1/02 ,  A61M1/34 ,  A61M1/36 ,  G01N33/491

Abstract: Devices, assemblies, and kits are disclosed for separating and/or metering a plasma sample from a patient's liquid test sample. Also disclosed are methods of producing and using same.

公开(公告)号：WO2021216543A1

公开(公告)日：2021-10-28

申请号：PCT/US2021/028142

申请日：2021-04-20

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

Inventor： KAUFFMANN, Aaron

IPC: B01L3/00 ,  B65D5/64 ,  B65D17/34 ,  B65D51/28 ,  B65D73/00

Abstract: Analytical assay reaction cartridges are disclosed that include a reagent tray containing a liquid reagent disposed therein and a flexible cover removably attached thereto. The flexible cover has a portion that extends beyond the reagent tray and that forms a tab portion extends through an opening in a lid member of the cartridge in order to facilitate removal of at least a portion of the cover and release of the liquid reagent. Also disclosed are analytical assay reaction kits that include the cartridges and diagnostic instruments for use with the analytical assay reaction cartridges/kits, as well as methods of making and using the cartridges/kits.

公开(公告)号：WO2021015808A1

公开(公告)日：2021-01-28

申请号：PCT/US2019/064636

申请日：2019-12-05

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS INC.

Inventor： KAUFFMANN, Aaron ,  LEDDEN, David ,  SAMPRONI, Jennifer

IPC: G01N33/49 ,  A61B5/15 ,  G01N33/72

Abstract: A tangent flow hemolysis blood testing assembly, device and method are described herein. The presently disclosed and claimed inventive concept(s) relate to a device(s), kit(s), and method(s) for injecting a patient's liquid test sample into a reaction vessel. More specifically, the presently disclosed and claimed inventive concept(s) relate to an improved liquid test sample injection device that comprises a plug that forms an airtight seal that facilitates the active injection of a liquid test sample into a reaction vessel, and kits and methods of use related thereto.