公开(公告)号：WO2016100557A3

公开(公告)日：2016-11-24

申请号：PCT/US2015066169

申请日：2015-12-16

Applicant: SIO2 MEDICAL PRODUCTS INC

Inventor： TAHA AHMAD ,  FELTS JOHN T

IPC: C08J7/12

CPC classification number: C08J7/123 ,  C08J2323/12 ,  C12M23/20

Abstract: A method is provided for treating a surface of a substrate. The method includes treating the surface with plasma comprising one or more non-polymerizing compounds. The converted surface has a biomolecule recovery percentage greater than the biomolecule recovery percentage of the surface prior to treatment according to the method.

Abstract translation: 提供了一种处理基材表面的方法。 该方法包括用包含一种或多种非聚合化合物的血浆处理表面。 按照该方法，转化表面的生物分子回收率大于处理前表面的生物分子回收率。

公开(公告)号：WO2017031354A3

公开(公告)日：2017-05-04

申请号：PCT/US2016047622

申请日：2016-08-18

Applicant: SIO2 MEDICAL PRODUCTS INC

Inventor： WILLS MATTHEW ,  TAHA AHMAD ,  WEIKART CHRISTOPHER

IPC: C23C16/04 ,  A61J1/05 ,  A61L31/08 ,  C23C16/30 ,  C23C16/40 ,  C23C16/515

CPC classification number: C23C16/045 ,  A61L27/34 ,  A61L29/085 ,  A61L31/06 ,  C23C16/30 ,  C23C16/401 ,  C23C16/515 ,  C08L83/04

Abstract: Processing an evacuated blood sample collection tube or other vessel by plasma enhanced chemical vapor deposition to apply a tie coating or layer (289), a barrier coating or layer (288), and optionally one or more additional coatings or layers. The tie coating or layer of SiOxCy is applied under partial vacuum and, while maintaining the partial vacuum unbroken in the lumen, the barrier coating or layer is applied. Then optionally, while maintaining the partial vacuum unbroken in the lumen, a pH protective coating or layer of SiOxCy can be applied. As a result of this processing, a coated vessel is produced having a lower gas permeation rate constant into the lumen than a corresponding vessel made by the same process except breaking the partial vacuum in the lumen between applying the tie coating or layer and applying the barrier coating or layer. Retention features are also described for keeping the vessels stoppered during exposure to reduced ambient pressure.

Abstract translation: 通过等离子体增强化学气相沉积处理抽空的血液样本收集管或其他容器以施加连接涂层或层（289），阻挡涂层或层（288）以及任选地一个或多个另外的涂层或层。 在部分真空下施加粘结涂层或SiOxCy层，并且在保持部分真空在管腔中不破损的同时，施加阻隔涂层或涂层。 然后可选地，在保持部分真空在管腔内不破裂的同时，可以施加pH保护涂层或SiOxCy层。 作为该处理的结果，产生具有比通过相同过程制造的相应容器更低的气体渗透速率进入管腔的涂覆容器，除了在施加粘结涂层或涂层和施加阻挡层之间破坏内腔中的局部真空之外 涂层或层。 还描述了保持特征以在暴露于降低的环境压力期间保持容器塞住。