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    PROCESS FOR THE INTERNAL COATING OF HOLLOW BODIES
    1.
    发明申请
    PROCESS FOR THE INTERNAL COATING OF HOLLOW BODIES 审中-公开
    空心体内涂层工艺

    公开(公告)号：WO2014059012A4

    公开(公告)日：2014-07-03

    申请号：PCT/US2013064121

    申请日：2013-10-09

    Applicant: SIO2 MEDICAL PRODUCTS INC

    Inventor： KINNEY SHAWN ,  WEIKART CHRISTOPHER ,  HUNT BENJAMIN ,  RAICHE ADRIAN ,  FITZPATRICK BRIAN ,  SAGONA PETER J ,  STEVENSON ADAM ,  FELTS JOHN T ,  FISK THOMAS E

    IPC: C23C16/04 ,  C08J7/00 ,  C23C16/40 ,  C23C16/50

    CPC classification number: C23C16/50 ,  A61J1/065 ,  A61M2205/0238 ,  A61M2207/00 ,  A61M2209/06 ,  C23C16/045 ,  C23C16/401

    Abstract: A method is disclosed in which a vapor-deposited coating or layer is directly or indirectly applied to at least a portion of the internal wall of the barrel of a capped pre-assembly comprising a barrel, a dispensing portion, and a shield. The shield is secured to the barrel and at least substantially isolates the distal opening of the dispensing portion from pressure conditions outside the shield. A vapor-deposited coating or layer is applied directly or indirectly to at least a portion of the internal wall of the barrel while the pre-assembly is capped. The coating or layer is applied under conditions effective to maintain communication between the barrel lumen and the dispensing portion lumen via the proximal opening at the end of the applying step. The capped pre-assembly can be pressure tested easily and rapidly, for example with a test duration between 1 and 60 seconds, to determine whether it has container closure integrity.

    Abstract translation: 公开了一种方法，其中将气相沉积的涂层或层直接或间接地施加到包括枪管，分配部分和防护罩的加盖预组件的枪管内壁的至少一部分上。 护罩固定到筒上并且至少基本上将分配部分的远侧开口与护罩外部的压力状况隔离开。 当预组件被封盖时，将气相沉积的涂层或层直接或间接地施加到筒的内壁的至少一部分。 涂层或层在有效保持在施加步骤结束时经由近侧开口保持桶腔与分配部分内腔之间的连通的条件下施加。 带盖的预装配件可以容易且快速地进行压力测试，例如测试持续时间在1至60秒之间，以确定其是否具有容器闭合完整性。

    PHARMACEUTICAL AND OTHER PACKAGING WITH LOW OXYGEN TRANSMISSION RATE
    2.
    发明申请
    PHARMACEUTICAL AND OTHER PACKAGING WITH LOW OXYGEN TRANSMISSION RATE 审中-公开
    药物和其他包装与低氧传输率

    公开(公告)号：WO2017031354A3

    公开(公告)日：2017-05-04

    申请号：PCT/US2016047622

    申请日：2016-08-18

    Applicant: SIO2 MEDICAL PRODUCTS INC

    Inventor： WILLS MATTHEW ,  TAHA AHMAD ,  WEIKART CHRISTOPHER

    IPC: C23C16/04 ,  A61J1/05 ,  A61L31/08 ,  C23C16/30 ,  C23C16/40 ,  C23C16/515

    CPC classification number: C23C16/045 ,  A61L27/34 ,  A61L29/085 ,  A61L31/06 ,  C23C16/30 ,  C23C16/401 ,  C23C16/515 ,  C08L83/04

    Abstract: Processing an evacuated blood sample collection tube or other vessel by plasma enhanced chemical vapor deposition to apply a tie coating or layer (289), a barrier coating or layer (288), and optionally one or more additional coatings or layers. The tie coating or layer of SiOxCy is applied under partial vacuum and, while maintaining the partial vacuum unbroken in the lumen, the barrier coating or layer is applied. Then optionally, while maintaining the partial vacuum unbroken in the lumen, a pH protective coating or layer of SiOxCy can be applied. As a result of this processing, a coated vessel is produced having a lower gas permeation rate constant into the lumen than a corresponding vessel made by the same process except breaking the partial vacuum in the lumen between applying the tie coating or layer and applying the barrier coating or layer. Retention features are also described for keeping the vessels stoppered during exposure to reduced ambient pressure.

    Abstract translation: 通过等离子体增强化学气相沉积处理抽空的血液样本收集管或其他容器以施加连接涂层或层（289），阻挡涂层或层（288）以及任选地一个或多个另外的涂层或层。 在部分真空下施加粘结涂层或SiOxCy层，并且在保持部分真空在管腔中不破损的同时，施加阻隔涂层或涂层。 然后可选地，在保持部分真空在管腔内不破裂的同时，可以施加pH保护涂层或SiOxCy层。 作为该处理的结果，产生具有比通过相同过程制造的相应容器更低的气体渗透速率进入管腔的涂覆容器，除了在施加粘结涂层或涂层和施加阻挡层之间破坏内腔中的局部真空之外 涂层或层。 还描述了保持特征以在暴露于降低的环境压力期间保持容器塞住。

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