公开(公告)号：WO1995012567A1

公开(公告)日：1995-05-11

申请号：PCT/US1994012661

申请日：1994-11-02

Applicant: SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH

Inventor： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH ,  DANISHEFSKY, Samuel, J. ,  BORNMANN, William, G. ,  QUENEAU, Yves ,  MAGEE, Thomas, V. ,  KROL, Walter, J. ,  MASTERS, John, J. ,  JUNG, David, K.

IPC: C07C49/543

CPC classification number: C07D305/14 ,  C07C45/29 ,  C07C45/59 ,  C07C49/613 ,  C07C49/687 ,  C07C49/713 ,  C07C49/723 ,  C07C49/737 ,  C07C49/747 ,  C07C49/753 ,  C07C49/757 ,  C07C255/31 ,  C07C255/46 ,  C07C403/08 ,  C07C403/14 ,  C07C403/16 ,  C07C403/20 ,  C07C2601/14 ,  C07C2601/16 ,  C07D317/72 ,  C07F7/1804

Abstract: The present invention provides three basic routes for the total synthesis of taxol having structure (I). The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogues of taxol and nortaxol.

Abstract translation: 本发明提供了具有结构（I）的紫杉醇的总合成的三条基本路线。 本发明还提供了在上述方法中制备的中间体，用于合成这些中间体的方法以及紫杉醇和诺泰莫酚的类似物。

公开(公告)号：WO1993020036A1

公开(公告)日：1993-10-14

申请号：PCT/US1993003031

申请日：1993-03-30

Applicant: SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH

Inventor： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH ,  DANISHEFSKY, Samuel, J. ,  BORNMANN, William, G. ,  QUENEAU, Yves ,  MAGEE, Thomas, V. ,  KROL, Walter, J.

IPC: C07C49/603

CPC classification number: C07C403/08 ,  C07C45/29 ,  C07C45/59 ,  C07C49/613 ,  C07C49/687 ,  C07C49/713 ,  C07C49/723 ,  C07C49/737 ,  C07C49/747 ,  C07C49/753 ,  C07C49/757 ,  C07C255/31 ,  C07C255/46 ,  C07C403/14 ,  C07C403/16 ,  C07C403/20 ,  C07C2601/14 ,  C07C2601/16 ,  C07D305/14 ,  C07D317/72 ,  C07F7/1804

Abstract: The present invention provides two basic routes for the total synthesis of taxol having structure (I). The present invention also provides the intermediates produced in the above processes, processes for synthesizing these intermediates as well as analogs to taxol. Both the intermediates and analogs to taxol may prove to be valuable anticancer agents.

Abstract translation: 本发明提供了具有结构（I）的紫杉醇的全合成的两条基本路线。 本发明还提供了在上述方法中制备的中间体，用于合成这些中间体的方法以及与紫杉醇的类似物。 紫杉醇的中间体和类似物都可能被证明是有价值的抗癌剂。