公开(公告)号：WO2003094996A1

公开(公告)日：2003-11-20

申请号：PCT/US2003/014868

申请日：2003-05-09

Applicant: SPIRATION, INC.

Inventor： SIROKMAN, William, A.

IPC: A61M1/00

CPC classification number: A61M1/0013 ,  A61M1/0023

Abstract: A device according to an aspect of the invention includes an air escapement conduit (52) having an inlet port providing air communication with a chest cavity (51) and an outlet port providing air communicaiton with a vacuum source (22), the conduit allowing an air flow from the inlet port (48) to the outlet port (49) in response to a pressure differential between the ports, and a detector responsive to the air flow that provides a signal (S1) related to the air flow. The device may include an indicator device (60) operable to provide evacuation information in response to the signal. The air escapement conduit may include a bubble chamber (42) or a valving mechanism (210). The detector may be a pressure differential sensor (122) operable to detect a difference in air pressure between the inlet port and the outlet port, and generate a signal related (S1) to the difference.

Abstract translation: 根据本发明的一个方面的装置包括具有提供与胸腔（51）空气连通的入口端口和提供空气通道与真空源（22）的出口的空气逸出导管（52），所述导管允许 响应于端口之间的压力差，从入口端口（48）到出口端口（49）的空气流和响应于空气流的检测器，其提供与空气流相关的信号（S1）。 该装置可以包括可操作以响应于该信号提供疏散信息的指示器装置（60）。 空气逸出导管可以包括气泡室（42）或阀机构（210）。 检测器可以是可操作以检测入口和出口之间的空气压力差的压力差传感器（122），并且产生与差异相关的信号（S1）。

公开(公告)号：WO2009135070A1

公开(公告)日：2009-11-05

申请号：PCT/US2009/042422

申请日：2009-04-30

Applicant: SPIRATION, INC. ,  ALFERNESS, Clifton, A. ,  SPRINGMEYER, MD, Steven, C. ,  SHUMAN, Brandon, James ,  SIROKMAN, William, A. ,  GONZALEZ, Hugo, X. ,  FINGER, Clinton, L.

Inventor： ALFERNESS, Clifton, A. ,  SPRINGMEYER, MD, Steven, C. ,  SHUMAN, Brandon, James ,  SIROKMAN, William, A. ,  GONZALEZ, Hugo, X. ,  FINGER, Clinton, L.

IPC: A61B1/267 ,  A61B5/083 ,  A61B5/087

CPC classification number: A61B1/2676 ,  A61B1/267 ,  A61B5/0833 ,  A61B5/0878

Abstract: Devices, systems, and methods for diagnosing physiological parameters of the lungs and treating associated medical conditions are disclosed herein. In particular, certain embodiments permit detection of air flow in lung passageways, air leaks, gas concentration (in particular oxygen), and temperature measurements. Measurements obtained using the devices, systems, and methods disclosed herein may also be used to determine optimal treatment sites for medical conditions such as emphysema, COPD, or lung volume reduction.

Abstract translation: 本文公开了用于诊断肺的生理参数和治疗相关医疗状况的装置，系统和方法。 特别地，某些实施例允许检测肺通道中的空气流，空气泄漏，气体浓度（特别是氧气）和温度测量。 使用本文公开的装置，系统和方法获得的测量也可用于确定医疗状况如肺气肿，COPD或肺体积减少的最佳治疗部位。

公开(公告)号：WO2013109398A1

公开(公告)日：2013-07-25

申请号：PCT/US2012/071832

申请日：2012-12-27

Applicant: SPIRATION, INC.

Inventor： SHEA, Richard, O. ,  SIROKMAN, William, A. ,  DILLARD, David, H. ,  GONZALES, Hugo, Xavier ,  SHUMAN, Brandon, James

IPC: A61B17/08

CPC classification number: A61B17/0057 ,  A61B17/12104 ,  A61B17/12145 ,  A61B17/1215 ,  A61B17/12159 ,  A61B17/12172 ,  A61B17/12177 ,  A61B2017/00575 ,  A61B2017/00579 ,  A61B2017/00584 ,  A61B2017/00588 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00606 ,  A61B2017/00619 ,  A61B2017/00623

Abstract: In certain embodiments, a device is configured to be compressed and inserted into the distal end of an endoscope. The delivery device can be configured to deliver the delivery catheter to the site of one or more fistulas in the wall of a body cavity or lumen within a patient. The delivery catheter is configured to deliver the device to the site of the one or more fistulas. The device is configured to expand at the site of the one or more fistulas and substantially seal the fistula in one or more directions. In some embodiments, at least a portion of the device is coated with and/or constructed of biocompatible material. In some configurations, the device is configured to be implanted for an extended period of time or even permanently. In some embodiments, at least a portion of the device is constructed of biodegradable, dissolvable and/or bioabsorbable material.

Abstract translation: 在某些实施例中，设备被配置为被压缩并插入到内窥镜的远端中。 递送装置可以被配置为将输送导管递送到患者体内或体腔的壁中的一个或多个瘘的部位。 输送导管被配置为将装置递送到一个或多个瘘的部位。 该装置构造成在一个或多个瘘的部位处膨胀并且在一个或多个方向上基本上密封瘘。 在一些实施例中，装置的至少一部分用生物相容性材料涂覆和/或构造。 在一些配置中，该设备被配置为长时间地甚至永久地植入。 在一些实施方案中，装置的至少一部分由可生物降解，可溶解和/或生物吸收材料构成。

公开(公告)号：WO2004006767A3

公开(公告)日：2004-01-22

申请号：PCT/US2003/021901

申请日：2003-07-15

Applicant: SPIRATION, INC. ,  SIROKMAN, William, A. ,  DEVORE, Lauri, J. ,  KUTSKO, James, M. ,  DILLARD, David, H. ,  WESTMAN, Peter, R.

Inventor： SIROKMAN, William, A. ,  DEVORE, Lauri, J. ,  KUTSKO, James, M. ,  DILLARD, David, H. ,  WESTMAN, Peter, R.

IPC: A61B5/107

Abstract: The invention provides a device for measuring an inside diameter of a body lumen, such as an air passageway. The device includes a flexible catheter (110, 310) having an inflation lumen (112, 312), a fluid dispenser (102, 200) in fluid communication with the inflation lumen and operable to communicate a measurable fluid volume change with the inflation lumen (112, 312), and an expandable member (120) in fluid communication with the inflation lumen and having a known relationship between volume and a changeable transverse dimension, the transverse dimension being changeable in response to fluid volume changes of the fluid dispenser and arranged for placement adjacent to opposing portions of an interior wall of the air passageway (80). The expandable member (120) may be dimensioned for transoral placement into the air passageway (80, and may comprise a balloon that includes a complaint material or a non-compliant material.

公开(公告)号：WO2013148220A1

公开(公告)日：2013-10-03

申请号：PCT/US2013/031077

申请日：2013-03-13

Applicant: SPIRATION, INC.

Inventor： DILLARD, David, H. ,  FINGER, Clinton, L. ,  LILJEGREN, Erik ,  O'CONNELL, Desmond ,  SHEA, Richard, O. ,  SIROKMAN, William, A.

IPC: A61B17/00

CPC classification number: A61B17/50 ,  A61B17/00234 ,  A61B17/12104 ,  A61B17/12172 ,  A61B2017/00296 ,  A61B2017/12054 ,  A61F2/01 ,  A61F2002/011 ,  A61F2002/043

Abstract: A tool for manipulating a foreign body (e.g., a deployed medical device) can include an operative portion. The operative portion can be used to move the foreign body in the proximal and/or distal directions with respect to the removal/repositioning tool and/or the tissue surrounding the foreign body. In some embodiments, the tool can include a compressing portion that can be used to compress the foreign body as the foreign body is pulled by the operative portion in the proximal direction. The tool can further include a sleeve that can be used to transition the operative portion and/or compressing portion between an opened configuration and a closed configuration. In some embodiments, the tool can be used in conjunction with an endoscope to navigate the tool to the site of a foreign body within the body of a patient.

Abstract translation: 用于操纵异物（例如，部署的医疗装置）的工具可以包括可操作部分。 操作部分可以用于相对于移除/重新定位工具和/或围绕异物的组织在近端和/或远端方向上移动异物。 在一些实施例中，工具可以包括压缩部分，该压缩部分可以随着异物沿着近端方向被操作部分拉动而被用于压缩异物。 该工具还可以包括可用于在打开构型和闭合构型之间转换操作部分和/或压缩部分的套筒。 在一些实施例中，该工具可以与内窥镜结合使用以将该工具导航到患者身体内的异物的位置。

公开(公告)号：WO2005013835A1

公开(公告)日：2005-02-17

申请号：PCT/US2004/025458

申请日：2004-08-06

Applicant: SPIRATION, INC.

Inventor： GONZALEZ, Hugo, Xavier ,  SPRINGMEYER, Steven, C. ,  SIROKMAN, William, A.

IPC: A61B17/12

CPC classification number: A61B17/12104 ,  A61B17/12022 ,  A61B17/12136 ,  A61B17/12172 ,  A61B2017/00809 ,  A61B2017/12054 ,  A61F2002/043

Abstract: Systems for minimally invasively treating an air leak in a lung (10) comprise a balloon catheter (40) configured for locating an airway in fluid communication with the air leak, a one-way valve occlusion device (140) for occluding inspiratory airflow through the airway in clued communication with the air leak and a bronchoscope (30) and/or a delivery catheter (200) configured to deliver the occlusion device (140) the into a patient's airway in a position adjacent to a target section selected using the balloon catheter 40. The airway occlusion device (140) is preferably removed after the air leak has substantially permanently healed. The system can further include a substance to be injected into the airway on a distal side of the occlusion.

Abstract translation: 用于最小限度地侵入性地处理肺中的空气泄漏的系统（10）包括构造成用于定位与所述空气泄漏流体连通的气道的气囊导管（40），用于吸入吸气气流的单向阀闭塞装置（140） 与空气泄漏有联系的气道和支气管镜（30）和/或输送导管（200），其构造成将所述闭塞装置（140）输送到与使用所述气囊导管选择的目标部分相邻的位置处的患者气道 优选在空气泄漏基本上永久愈合之后去除气道阻塞装置（140）。 所述系统还可以包括要在所述闭塞的远端侧注入所述气道中的物质。