公开(公告)号：WO2015153502A1

公开(公告)日：2015-10-08

申请号：PCT/US2015/023413

申请日：2015-03-30

Applicant: SPIRATION, INC.

Inventor： JOHNSON, Timothy, J. ,  SHUMAN, Brandon, James ,  DILLARD, David, H.

IPC: A61F2/00

CPC classification number: A61B5/1076 ,  A61B1/00 ,  A61B1/012 ,  A61B1/267 ,  A61B5/08 ,  A61B5/1079 ,  A61B90/06 ,  A61B2090/061 ,  A61F2220/0016

Abstract: Embodiments of a sizing device that can be used to measure the size of airways lumens, such as those connected to lungs. The sizing device can have different expandable elements in order to accurately and consistently measure the particular dimensions of a lumen. In some embodiments, markings vie wable by a user can be used to determine the particular size.

Abstract translation: 尺寸测量装置的实施例可用于测量气道腔的尺寸，例如连接到肺的那些尺寸。 尺寸调节装置可以具有不同的可扩张元件，以便准确和一致地测量管腔的特定尺寸。 在一些实施例中，用户可以使用的标记可以用于确定特定尺寸。

公开(公告)号：WO2013148217A1

公开(公告)日：2013-10-03

申请号：PCT/US2013/031067

申请日：2013-03-13

Applicant: SPIRATION, INC.

Inventor： DILLARD, David, H. ,  GONZALEZ, Hugo, X. ,  HOFFMAN, Peter ,  SHUMAN, Brandon, James

IPC: A61B5/05 ,  A61B5/055

CPC classification number: A61B19/54 ,  A61B5/05 ,  A61B5/055 ,  A61B5/062 ,  A61B17/3468 ,  A61B18/04 ,  A61B18/1492 ,  A61B90/39 ,  A61B2018/00047 ,  A61B2018/00541 ,  A61B2018/00577 ,  A61B2090/3908 ,  A61B2090/392 ,  A61B2090/3954 ,  A61B2090/3966 ,  A61B2090/3995 ,  A61B2562/17 ,  A61N7/022

Abstract: Embodiments of the present invention include devices, systems, and methods for implanting and locating traceable markers in a region of a patient's body such as a lung, and in particular lung nodules which may be difficult to locate using traditional means. Further embodiments describe devices, systems, and methods that may be used to treat regions in the lung such as lung nodules with various treatment modalities including heating, microwave irradiation, chemical treatment, and which may be used in conjunction with embodiments of the traceable markers described herein.

Abstract translation: 本发明的实施例包括用于在患者身体（例如肺）的区域中植入和定位可跟踪标记的装置，系统和方法，特别是可能难以使用传统手段定位的肺结节。 另外的实施方案描述了可用于治疗肺中的区域的装置，系统和方法，例如具有各种治疗方式的肺结节，包括加热，微波照射，化学治疗，并且可以与所描述的可追踪标记的实施方案结合使用 于此。

公开(公告)号：WO2009135070A1

公开(公告)日：2009-11-05

申请号：PCT/US2009/042422

申请日：2009-04-30

Applicant: SPIRATION, INC. ,  ALFERNESS, Clifton, A. ,  SPRINGMEYER, MD, Steven, C. ,  SHUMAN, Brandon, James ,  SIROKMAN, William, A. ,  GONZALEZ, Hugo, X. ,  FINGER, Clinton, L.

Inventor： ALFERNESS, Clifton, A. ,  SPRINGMEYER, MD, Steven, C. ,  SHUMAN, Brandon, James ,  SIROKMAN, William, A. ,  GONZALEZ, Hugo, X. ,  FINGER, Clinton, L.

IPC: A61B1/267 ,  A61B5/083 ,  A61B5/087

CPC classification number: A61B1/2676 ,  A61B1/267 ,  A61B5/0833 ,  A61B5/0878

Abstract: Devices, systems, and methods for diagnosing physiological parameters of the lungs and treating associated medical conditions are disclosed herein. In particular, certain embodiments permit detection of air flow in lung passageways, air leaks, gas concentration (in particular oxygen), and temperature measurements. Measurements obtained using the devices, systems, and methods disclosed herein may also be used to determine optimal treatment sites for medical conditions such as emphysema, COPD, or lung volume reduction.

Abstract translation: 本文公开了用于诊断肺的生理参数和治疗相关医疗状况的装置，系统和方法。 特别地，某些实施例允许检测肺通道中的空气流，空气泄漏，气体浓度（特别是氧气）和温度测量。 使用本文公开的装置，系统和方法获得的测量也可用于确定医疗状况如肺气肿，COPD或肺体积减少的最佳治疗部位。

公开(公告)号：WO2013109398A1

公开(公告)日：2013-07-25

申请号：PCT/US2012/071832

申请日：2012-12-27

Applicant: SPIRATION, INC.

Inventor： SHEA, Richard, O. ,  SIROKMAN, William, A. ,  DILLARD, David, H. ,  GONZALES, Hugo, Xavier ,  SHUMAN, Brandon, James

IPC: A61B17/08

CPC classification number: A61B17/0057 ,  A61B17/12104 ,  A61B17/12145 ,  A61B17/1215 ,  A61B17/12159 ,  A61B17/12172 ,  A61B17/12177 ,  A61B2017/00575 ,  A61B2017/00579 ,  A61B2017/00584 ,  A61B2017/00588 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00606 ,  A61B2017/00619 ,  A61B2017/00623

Abstract: In certain embodiments, a device is configured to be compressed and inserted into the distal end of an endoscope. The delivery device can be configured to deliver the delivery catheter to the site of one or more fistulas in the wall of a body cavity or lumen within a patient. The delivery catheter is configured to deliver the device to the site of the one or more fistulas. The device is configured to expand at the site of the one or more fistulas and substantially seal the fistula in one or more directions. In some embodiments, at least a portion of the device is coated with and/or constructed of biocompatible material. In some configurations, the device is configured to be implanted for an extended period of time or even permanently. In some embodiments, at least a portion of the device is constructed of biodegradable, dissolvable and/or bioabsorbable material.

Abstract translation: 在某些实施例中，设备被配置为被压缩并插入到内窥镜的远端中。 递送装置可以被配置为将输送导管递送到患者体内或体腔的壁中的一个或多个瘘的部位。 输送导管被配置为将装置递送到一个或多个瘘的部位。 该装置构造成在一个或多个瘘的部位处膨胀并且在一个或多个方向上基本上密封瘘。 在一些实施例中，装置的至少一部分用生物相容性材料涂覆和/或构造。 在一些配置中，该设备被配置为长时间地甚至永久地植入。 在一些实施方案中，装置的至少一部分由可生物降解，可溶解和/或生物吸收材料构成。

公开(公告)号：WO2015153507A1

公开(公告)日：2015-10-08

申请号：PCT/US2015/023421

申请日：2015-03-30

Applicant: SPIRATION, INC.

Inventor： DILLARD, David, H. ,  JOHNSON, Timothy, J. ,  SHUMAN, Brandon, James ,  BAILLARGEON, Jean-Martin ,  LAUER, Lisa

IPC: A61B17/12

CPC classification number: A61B5/1076 ,  A61B1/00 ,  A61B1/012 ,  A61B1/267 ,  A61B5/08 ,  A61B5/1079 ,  A61B17/12036 ,  A61B17/12104 ,  A61B17/12109 ,  A61B17/12172 ,  A61B17/12177 ,  A61B2017/00699 ,  A61B2017/00867 ,  A61F2/04 ,  A61F2002/043 ,  A61F2220/0016

Abstract: Devices and methods for occluding airways in at least one direction are disclosed, in some cases, the devices include anchoring mechanisms configured to keep an operative portion of the device (e.g., a valve) in position along a length of a lumen in which the device is deployed. The anchoring mechanisms can include anchors configured to settle into the lumen walls with little or no axial movement of the operative portion of the device. In some embodiments, the anchoring mechanisms include a secondary set of anchors configured to engage with the lumen wall to reduce, inhibit, or prevent axial movement of the operative portion of the device when the primary anchors settle into the walls of the lumen.

Abstract translation: 公开了用于在至少一个方向上封闭气道的装置和方法，在一些情况下，所述装置包括锚定机构，所述锚固机构被配置成将装置的操作部分（例如，阀）沿着管腔的长度保持在适当位置， 被部署。 锚定机构可以包括构造成沉降到管腔壁中的锚，其中装置的操作部分几乎没有或没有轴向移动。 在一些实施例中，锚固机构包括辅助锚固件组，其被配置为当主锚固定到管腔的壁中时与腔壁接合以减小，抑制或阻止装置的操作部分的轴向移动。

公开(公告)号：WO2015153500A1

公开(公告)日：2015-10-08

申请号：PCT/US2015/023410

申请日：2015-03-30

Applicant: SPIRATION, INC.

Inventor： SHUMAN, Brandon, James

IPC: A61B5/107

CPC classification number: A61B5/1076 ,  A61B1/00 ,  A61B1/012 ,  A61B1/267 ,  A61B5/08 ,  A61B5/103 ,  A61B5/107 ,  A61B5/1079 ,  A61B90/06 ,  A61B2090/061 ,  A61F2/04 ,  A61F2002/043 ,  A61F2220/0016

Abstract: Embodiments of a simulated valve device can be used to determine whether a valve device would fit within a particular airway. The simulated valve device can include a shaft having at least one strut extending radially therefrom. The strut and at least part of the shaft can be surrounded by a membrane for viewing through a bronchoscope. In some embodiments, the membrane can include markings for viewing by a user.

Abstract translation: 可以使用模拟阀装置的实施例来确定阀装置是否适合特定气道。 模拟的阀装置可以包括具有至少一个从其径向延伸的支柱的轴。 支柱和轴的至少一部分可以被膜包围以通过支气管镜观察。 在一些实施例中，膜可以包括用于用户观看的标记。

公开(公告)号：WO2003065897A1

公开(公告)日：2003-08-14

申请号：PCT/US2003/000165

申请日：2003-01-03

Applicant: SPIRATION, INC. ,  SHUMAN, Brandon, James

Inventor： SHUMAN, Brandon, James

IPC: A61B17/00

CPC classification number: A61B17/32053 ,  A61B17/12 ,  A61B17/122 ,  A61B17/1227 ,  A61B17/282 ,  A61B17/3211 ,  A61B90/40 ,  A61B2017/00287 ,  A61B2017/1225 ,  A61B2017/320052

Abstract: The invention provides for treating deleterious body tissue located within healthy body tissue by isolating the deleterious tissue (70) from blood, air, and fluid communication. The device includes two structures (82, 86), each having a corresponding circumferential surface (83, 87) arranged to circumscribe the deleterious body tissue. When the first and second circumferential surfaces (83, 87) are brought together in an aligned relationship with the deleterious body tissue between the structures (82, 86), the two circumferential surfaces (83, 87) co-act to isolate the deleterious body tissue (70) from communication with the healthy body tissue. The deleterious tissue is resected according to the invention by allowing it to become ischemic and necrotic, or by excision.

Abstract translation: 本发明提供通过将有害组织（70）与血液，空气和流体连通分离来治疗位于健康身体组织内的有害身体组织。 该装置包括两个结构（82,86），每个结构具有布置成围绕有害身体组织的对应的圆周表面（83,87）。 当第一和第二圆周表面（83,87）以与结构（82,86）之间的有害身体组织对齐的关系一起被接合在一起时，两个圆周表面（83,87）共同作用以隔离有害体 组织（70）与健康的身体组织通信。 根据本发明，通过使有害组织变得缺血和坏死，或通过切除来切除有害组织。