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    LIMB POSITIONING SYSTEM
    1.
    发明申请
    LIMB POSITIONING SYSTEM 审中-公开
    LIMB定位系统

    公开(公告)号：WO2015138317A1

    公开(公告)日：2015-09-17

    申请号：PCT/US2015/019436

    申请日：2015-03-09

    Applicant: STRYKER CORPORATION ,  FOSSEZ, John R. ,  SHIELS, Paul

    Inventor： FOSSEZ, John R. ,  SHIELS, Paul

    IPC: A61G13/12 ,  A61G13/10

    CPC classification number: A61G13/1245 ,  A61G13/101 ,  A61G13/1205 ,  A61G13/125 ,  A61G13/129

    Abstract: A limb positioning system (10) includes a clamp assembly (100), a pylon and bar assembly (200), a sled assembly (300), and a limb positioning assembly (400). The clamp assembly attaches to a rail (30) of a table and accepts a pylon (220) connected to a bar (240). The pylon has a plurality of pylon bars (222a, 222b) that are secured by the clamp assembly. A base bar (240) extends from the pylon, and is attachable to an extension bar (260) to provide a longer track for the sled assembly. The sled assembly is biased to be locked with respect to the base bar. The limb holding assembly includes a boot (402) coupled to the sled via a connector (460) near the heel. The connector is tapered and insertable into a correspondingly tapered section of a ball (380) that sits within the sled assembly, the ball being capable of polyaxial motion.

    Abstract translation: 肢体定位系统（10）包括夹具组件（100），挂架和杆组件（200），滑动组件（300）和肢体定位组件（400）。 夹具组件连接到工作台的轨道（30）并且接受连接到杆（240）的塔架（220）。 塔架具有多个由夹具组件固定的塔架杆（222a，222b）。 基座杆240从支架延伸，并且可附接到延伸杆260，以为滑轨组件提供更长的轨道。 滑车组件被偏压以相对于基座杆被锁定。 所述肢体保持组件包括通过靠近脚跟处的连接器（460）联接到所述滑板的靴子（402）。 连接器是锥形的并且可插入到位于滑动组件内的球（380）的相应的锥形部分中，球能够进行多轴运动。

    MATERIALS AND METHODS RELATING TO CELL BASED THERAPIES
    2.
    发明申请
    MATERIALS AND METHODS RELATING TO CELL BASED THERAPIES 审中-公开
    与细胞治疗相关的材料和方法

    公开(公告)号：WO2009136168A1

    公开(公告)日：2009-11-12

    申请号：PCT/GB2009/001149

    申请日：2009-05-08

    Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW ,  SHIELS, Paul

    Inventor： SHIELS, Paul

    IPC: C12N5/06

    CPC classification number: A61K35/12 ,  G01N33/5073

    Abstract: The invention relates to the provision of a novel cell population that can be used for tissue regeneration and the treatment of disease states associated with cell degeneration for age related tissue changes. The cell population are derived from adult stem/progenitor cells which are characterised by being positive or negative to the Thyl.1 cell marker.

    Abstract translation: 本发明涉及提供可用于组织再生和治疗与年龄相关组织变化的细胞变性相关的疾病状态的新型细胞群体。 细胞群源自成体干细胞/祖细胞，其特征在于对Thyl.1细胞标记物呈阳性或阴性。

    PANCREATIC DUCT PROGENITOR CELLS AND MICRORNA OBTAINED THEREFROM FOR USE IN TISSUE REGENERATION
    3.
    发明申请
    PANCREATIC DUCT PROGENITOR CELLS AND MICRORNA OBTAINED THEREFROM FOR USE IN TISSUE REGENERATION 审中-公开

    公开(公告)号：WO2012020308A3

    公开(公告)日：2012-02-16

    申请号：PCT/IB2011/002048

    申请日：2011-08-12

    Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW ,  SHIELS, Paul

    Inventor： SHIELS, Paul

    IPC: A61K35/22 ,  A61K35/39 ,  G01N33/50 ,  A61P3/10 ,  A61P9/10 ,  A61P13/12 ,  C12N15/113

    Abstract: The present invention provides, among other things, improved compositions and methods for the treatment of tissue damage (e.g., acute or chronic) and related diseases, disorders or conditions based on the use of pathfinder cells, extracellular secretomes thereof, and/or pathfinder cell-associated micro RNAs. In some embodiments, the present invention provides a method for treating tissue damage (e.g., acute or chronic) comprising a step of administering a population of cells to an individual suffering from a disease, disorder or condition characterized by acute damage to one or more tissues, wherein the cells are originated from an adult tissue and wherein the cells induce tissue repair, regeneration, remodeling, reconstitution or differentiation. In some embodiments, the present invention provides a method for treating inflammation comprising a step of administering a population of cells, or extracellular secretomes thereof, to an individual suffering from a disease, disorder or condition characterized by inflammation of one or more tissues, wherein the cells are originated from an adult tissue and wherein the cells induce an anti-inflammatory response.

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