公开(公告)号：WO2015150490A1

公开(公告)日：2015-10-08

申请号：PCT/EP2015/057256

申请日：2015-04-01

Applicant: SWEDISH ORPHAN BIOVITRUM AB (PUBL)

Inventor： BERGHARD, Charlotta ,  NORDLING, Erik ,  SVENSSON GELIUS, Stefan ,  TJERNBERG, Agneta

IPC: C07K14/435

CPC classification number: C12N9/14 ,  A61K38/00 ,  C12N9/96 ,  C12Y310/01001

Abstract: Disclosed herein are a modified sulfamidase, a composition comprising a modified sulfamidase, as well as methods for preparing a modified sulfamidase and therapeutic use of such a sulfamidase. In particular, the present disclosure relates to a modified sulfamidase comprising substantially no epitopes for glycan recognition receptors, thereby enabling transportation of said sulfamidase across the blood brain barrier of a mammal, wherein said sulfamidase has catalytic activity in the brain of said mammal.

Abstract translation: 本文公开了改性的磺酰胺酶，包含改性的磺酰胺酶的组合物，以及制备修饰的磺酰胺酶的方法和这种磺酰胺酶的治疗用途。 具体地说，本公开内容涉及基本上不含聚糖识别受体的表位的修饰的磺酰胺酶，从而使所述磺酰胺酶能够跨越哺乳动物的血脑屏障传递，其中所述的磺酰胺酶在所述哺乳动物的脑中具有催化活性。