公开(公告)号：WO03046001A3

公开(公告)日：2003-09-25

申请号：PCT/CA0201665

申请日：2002-10-31

Applicant: SYN X PHARMA INC

Inventor： JACKOWSKI GEORGE ,  MARSHALL JOHN

IPC: G01N27/62 ,  C07K14/47 ,  C07K14/775 ,  C07K16/18 ,  G01N33/483 ,  G01N33/53 ,  G01N33/577 ,  G01N33/68 ,  A61K38/17

CPC classification number: C07K14/775 ,  G01N33/6893 ,  Y10T436/24

Abstract: The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample.The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease

Abstract translation: 本发明涉及使用结合质谱和飞行时间检测程序的预备步骤的组合以最大化在特定样品内可验证的生物聚合物的多样性。然后在这样的样品内验证的生物聚合物群组然后 参照它们证明至少一种特定疾病状态的能力来看待; 由此使得诊断者能够获得表征所述至少一种疾病状态相对于识别所述生物聚合物的存在和/或缺失的存在或不存在，预测疾病风险评估以及开发针对所述疾病的治疗途径的能力

公开(公告)号：WO03045991A3

公开(公告)日：2003-09-04

申请号：PCT/CA0201645

申请日：2002-10-31

Applicant: SYN X PHARMA INC

Inventor： JACKOWSKI GEORGE ,  MARSHALL JOHN

IPC: G01N27/62 ,  A61K38/00 ,  A61K45/00 ,  A61P25/28 ,  C07K14/47 ,  C07K16/18 ,  C12P21/08 ,  G01N33/483 ,  G01N33/53 ,  G01N33/577 ,  G01N33/68 ,  A61K38/17 ,  C07K16/44

CPC classification number: C07K14/4711 ,  A61K38/00 ,  C07K14/472 ,  G01N33/6896 ,  G01N2800/2821

Abstract: The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.

Abstract translation: 本发明涉及使用与质谱和飞行时间检测程序相结合的预备步骤的组合，以最大化在特定样品内可验证的生物聚合物的多样性。 然后参照它们证明至少一种特定疾病状态的能力来观察在这样的样品中验证的生物聚合物群组; 由此使得诊断者能够获得表征所述至少一种疾病状态相对于识别所述生物聚合物的存在和/或不存在，预测疾病风险评估以及开发针对所述疾病的治疗途径的存在或不存在的能力。

公开(公告)号：WO03054014A3

公开(公告)日：2003-08-21

申请号：PCT/CA0201653

申请日：2002-10-31

Applicant: SYN X PHARMA INC

Inventor： JACKOWSKI GEORGE ,  MARSHALL JOHN

IPC: G01N27/62 ,  A61K45/00 ,  A61P25/28 ,  C07K14/775 ,  C07K16/18 ,  C12P21/08 ,  G01N33/483 ,  G01N33/53 ,  G01N33/577 ,  G01N33/68 ,  A61K38/17

CPC classification number: C07K14/775

Abstract: The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.

Abstract translation: 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在的能力，以相对于识别所述生物聚合物的存在和/或不存在，预测疾病风险评估以及开发针对所述疾病的治疗途径。

公开(公告)号：WO02088711A3

公开(公告)日：2003-01-16

申请号：PCT/CA0200627

申请日：2002-04-29

Applicant: SYN X PHARMA INC

Inventor： JACKOWSKI GEORGE ,  THATCHER BRAD ,  VREES TAMMY ,  YANTHA JASON ,  MARSHALL JOHN

IPC: G01N33/68 ,  C07K7/08 ,  C07K16/36

CPC classification number: G01N33/6893 ,  G01N2800/042 ,  Y10T436/24 ,  Y10T436/25

Abstract: The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer.

Abstract translation: 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在与识别所述生物聚合物的存在和/或不存在的能力。

公开(公告)号：WO02088743A3

公开(公告)日：2003-01-03

申请号：PCT/CA0200618

申请日：2002-04-29

Applicant: SYN X PHARMA INC

Inventor： JACKOWSKI GEORGE ,  THATCHER BRAD ,  MARSHALL JOHN ,  YANTHA JASON ,  VREES TAMMY

IPC: G01N33/68 ,  C07K7/06 ,  C07K16/18

CPC classification number: G01N33/6893 ,  G01N2800/042 ,  Y10T436/24 ,  Y10T436/25

Abstract: The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer.

Abstract translation: 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在与识别所述生物聚合物的存在和/或不存在的能力。

公开(公告)号：WO02088724A3

公开(公告)日：2003-01-03

申请号：PCT/CA0200612

申请日：2002-04-26

Applicant: SYN X PHARMA INC

Inventor： JACKOWSKI GEORGE ,  THATCHER BRAD ,  VREES TAMMY ,  YANTHA JASON ,  MARSHALL JOHN

IPC: G01N33/68 ,  C07K7/08 ,  C07K16/36

CPC classification number: G01N33/6893 ,  G01N2800/042 ,  G01N2800/324 ,  Y10T436/24 ,  Y10T436/25

Abstract: The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer.

Abstract translation: 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在与识别所述生物聚合物的存在和/或不存在的能力。

公开(公告)号：WO02088729A3

公开(公告)日：2002-12-27

申请号：PCT/CA0200629

申请日：2002-04-29

Applicant: SYN X PHARMA INC

Inventor： JACKOWSKI GEORGE ,  THATCHER BRAD ,  VREES TAMMY ,  YANTHA JASON ,  MARSHALL JOHN

IPC: G01N33/68 ,  C07K7/08 ,  C07K16/36

CPC classification number: G01N33/6893 ,  Y10T436/13 ,  Y10T436/24

Abstract: The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer.

Abstract translation: 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在与识别所述生物聚合物的存在和/或不存在的能力。

公开(公告)号：WO02088728A3

公开(公告)日：2002-12-27

申请号：PCT/CA0200619

申请日：2002-04-29

Applicant: SYN X PHARMA INC

Inventor： JACKOWSKI GEORGE ,  THATCHER BRAD ,  MARSHALL JOHN ,  YANTHA JASON ,  VREES TAMMY

IPC: G01N33/68 ,  C07K7/06 ,  C07K16/36

CPC classification number: G01N33/6893 ,  G01N2800/324 ,  Y10T436/24 ,  Y10T436/25

Abstract: The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer.

Abstract translation: 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在与识别所述生物聚合物的存在和/或不存在的能力。

公开(公告)号：WO03054547A3

公开(公告)日：2003-09-04

申请号：PCT/CA0201671

申请日：2002-10-31

Applicant: SYN X PHARMA INC

Inventor： JACKOWSKI GEORGE ,  ZHANG RULIN

IPC: G01N33/53 ,  G01N33/68

CPC classification number: G01N33/68

Abstract: A method for diagnosing various forms of dementia, including MCI, and Alzheimer's disease (AD) is disclosed. The method involves directly detecting the presence of a biochemical marker, specifically thrombospondin, in bodily fluid, preferably blood or a blood product. The detection is by an immunoassay incorporating an antibody specific to thrombospondin, or alternatively an autoantibody to a thrombospondin antibody.

Abstract translation: 公开了一种用于诊断各种形式的痴呆的方法，包括MCI和阿尔茨海默病（AD）。 该方法包括直接检测生物化学标记物，特别是血小板反应蛋白在体液中，优选血液或血液制品中的存在。 检测是通过结合抗血小板反应蛋白特异性抗体的免疫测定法，或者血栓反应蛋白抗体的自身抗体。

公开(公告)号：WO02088709A3

公开(公告)日：2003-05-01

申请号：PCT/CA0200621

申请日：2002-04-29

Applicant: SYN X PHARMA INC

Inventor： JACKOWSKI GEORGE ,  STANTON ERIC B

IPC: C40B30/04 ,  G01N33/68

CPC classification number: C40B30/04 ,  G01N33/6845

Abstract: The present invention provides a biochemically-based methodology for ascertaining the presence and/or verifying the historical release of biopolymers, which have been shown to be indicative of a disease state or are predictive of the development of said disease state.

Abstract translation: 本发明提供了用于确定存在和/或验证生物聚合物的历史释放的基于生物化学的方法，其已被证明是指示疾病状态或预示出所述疾病状态的发展。