公开(公告)号：WO2022040220A2

公开(公告)日：2022-02-24

申请号：PCT/US2021/046353

申请日：2021-08-17

Applicant: TECHNOVAX, INC.

Inventor： GALARZA, Jose M. ,  WEN, Ke ,  MAZBOUDI, Ryan ,  RESCH, Matthew D.

IPC: A61K39/215

Abstract: The present application relates to SARS-CoV-2 virus-like particles (VLP) and related plasmids, compositions, and methods. The VLP can comprise a modified spike glycoprotein, a matrix protein, a nucleoprotein N and an envelope protein of SARS-CoV-2, where the modified spike glycoprotein comprises an SI domain and an S2 domain, and includes one or more modifications. These modifications can include: linking the SI and S2 domains via generation of disulfides bonds between the SI and S2 domains; linking intra-polypeptide and inter-polypeptide S2 helices of the S2 domain; and substitution of one or more non-cysteine residues with a cysteine residue to generate one or more disulfide bonds. The modifications can stabilize a prefusion conformation of the spike glycoprotein and prohibit a transition to a post-fusion structure.

公开(公告)号：WO2007130330A2

公开(公告)日：2007-11-15

申请号：PCT/US2007/010405

申请日：2007-04-30

Applicant: TECHNOVAX, INC. ,  GALARZA, Jose M. ,  MATASSOV, Demetrius

Inventor： GALARZA, Jose M. ,  MATASSOV, Demetrius

IPC: A61K39/145

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/70 ,  C12N7/00 ,  C12N2760/16023 ,  C12N2760/16034 ,  C12N2760/16071 ,  C12N2760/16122 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2760/16222 ,  C12N2760/16223 ,  C12N2760/16234 ,  C12P21/005

Abstract: Polyvalent influenza virus-like particles (VLPs) comprising influenza antigenic polypeptides are described. Also described are compositions comprising these polyvalent VLPs as well as methods of making and using these VLPs.

Abstract translation: 描述了包含流感抗原多肽的多价流感病毒样颗粒（VLP）。 还描述了包含这些多价VLP的组合物以及制备和使用这些VLP的方法。

公开(公告)号：WO2016210127A1

公开(公告)日：2016-12-29

申请号：PCT/US2016/039011

申请日：2016-06-23

Applicant: TECHNOVAX, INC.

Inventor： GALARZA, Jose M. ,  BOIGARD, Helene ,  MARTIN, George

IPC: A61K39/12 ,  A61K39/145 ,  A61K47/22

CPC classification number: A61K39/12 ,  A61K39/145 ,  A61K2039/5258 ,  A61P31/14 ,  C07K14/005 ,  C12N7/00 ,  C12N9/506 ,  C12N2770/24023 ,  C12N2770/24034 ,  C12N2770/24134 ,  Y02A50/386 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/392 ,  Y02A50/394

Abstract: Described herein are flavivirus virus-like particles (VLPs) that display on their surfaces antigenic flavivirus proteins. Also described are methods of making and using these VLPs.

Abstract translation: 本文描述的是黄病毒病毒样颗粒（VLPs），其在其表面上显示抗原性黄病毒蛋白。 还描述了制造和使用这些VLP的方法。

公开(公告)号：WO2017040387A2

公开(公告)日：2017-03-09

申请号：PCT/US2016/049226

申请日：2016-08-29

Applicant: TECHNOVAX, INC.

Inventor： GALARZA, Jose M. ,  CIMICA, Velasco ,  BOIGARD, Helene

IPC: A61K39/12 ,  C12N15/86

CPC classification number: A61K39/12 ,  C12N2760/18323 ,  C12N2760/18334 ,  C12N2760/18534 ,  C12N2760/18571

Abstract: Described herein are virus-like particles (VLPs) that display on their surfaces antigenic paramyxovirus (e.g., RSV and/or MPV) proteins. Also described are methods of making and using these VLPs.

Abstract translation: 本文描述的是在其表面上显示抗原性副粘病毒（例如RSV和/或MPV）蛋白的病毒样颗粒（VLP）。 还描述了制造和使用这些VLP的方法。