公开(公告)号：WO2014099931A1

公开(公告)日：2014-06-26

申请号：PCT/US2013/075697

申请日：2013-12-17

Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

Inventor： GARCIA-SASTRE, Adolfo ,  PALESE, Peter ,  KRAMMER, Florian

IPC: A61K39/145 ,  A61K39/00

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/521 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/70 ,  C07K14/005 ,  C12N7/00 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2760/16223 ,  C12N2760/16234

Abstract: Provided herein are chimeric influenza hemagglutinin (HA) polypeptides, compositions comprising the same, vaccines comprising the same, and methods of their use.

Abstract translation: 本文提供嵌合流感血凝素（HA）多肽，包含其的组合物，包含其的疫苗及其使用方法。

公开(公告)号：WO2012036993A1

公开(公告)日：2012-03-22

申请号：PCT/US2011/051072

申请日：2011-09-09

Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION ,  ROSS, Ted, M. ,  GILES, Brendan, M.

Inventor： ROSS, Ted, M. ,  GILES, Brendan, M.

IPC: C12N15/33 ,  C12N15/44 ,  C12N15/63

CPC classification number: A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/5258 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/575 ,  C07K14/005 ,  C07K14/11 ,  C07K2319/00 ,  C12N7/00 ,  C12N9/2402 ,  C12N15/86 ,  C12N2760/16122 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2760/16143 ,  C12N2760/16171 ,  C12N2760/16223 ,  C12N2760/16234 ,  C12N2760/16323 ,  C12N2760/16334 ,  C12N2800/22 ,  C12Y302/01018

Abstract: Described herein is the development of a computationally optimized influenza HA protein that elicits broadly reactive immune response to all H5N1 influenza virus isolates. The optimized HA protein was developed through a series of HA protein alignments, and subsequent generation of consensus sequences, for clade 2 H5N1 influenza virus isolates. The final consensus HA amino acid sequence was reverse translated and optimized for expression in mammalian cells. It is disclosed herein that influenza virus-like particles containing the optimized HA protein are an effective vaccine against H5N1 influenza virus infection in animals.

Abstract translation: 本文描述的是计算优化的流感HA蛋白质的开发，其引起对所有H5N1流感病毒分离株的广泛反应性免疫应答。 通过一系列HA蛋白质比对和随后的共有序列的产生，用于进化枝2 H5N1流感病毒分离株开发优化的HA蛋白质。 将最终的共有HA氨基酸序列反向翻译并优化用于在哺乳动物细胞中表达。 本文公开了含有优化的HA蛋白的流感病毒样颗粒是针对动物中H5N1流感病毒感染的有效疫苗。

公开(公告)号：WO2007130330A3

公开(公告)日：2008-03-06

申请号：PCT/US2007010405

申请日：2007-04-30

Applicant: TECHNOVAX INC ,  GALARZA JOSE M ,  MATASSOV DEMETRIUS

Inventor： GALARZA JOSE M ,  MATASSOV DEMETRIUS

IPC: A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K39/295 ,  A61K39/385

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/70 ,  C12N7/00 ,  C12N2760/16023 ,  C12N2760/16034 ,  C12N2760/16071 ,  C12N2760/16122 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2760/16222 ,  C12N2760/16223 ,  C12N2760/16234 ,  C12P21/005

Abstract: Polyvalent influenza virus-like particles (VLPs) comprising influenza antigenic polypeptides are described. Also described are compositions comprising these polyvalent VLPs as well as methods of making and using these VLPs.

Abstract translation: 描述了包含流感抗原多肽的多价流感病毒样颗粒（VLP）。 还描述了包含这些多价VLP的组合物以及制备和使用这些VLP的方法。

公开(公告)号：WO2007130330A2

公开(公告)日：2007-11-15

申请号：PCT/US2007/010405

申请日：2007-04-30

Applicant: TECHNOVAX, INC. ,  GALARZA, Jose M. ,  MATASSOV, Demetrius

Inventor： GALARZA, Jose M. ,  MATASSOV, Demetrius

IPC: A61K39/145

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/545 ,  A61K2039/70 ,  C12N7/00 ,  C12N2760/16023 ,  C12N2760/16034 ,  C12N2760/16071 ,  C12N2760/16122 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2760/16222 ,  C12N2760/16223 ,  C12N2760/16234 ,  C12P21/005

Abstract: Polyvalent influenza virus-like particles (VLPs) comprising influenza antigenic polypeptides are described. Also described are compositions comprising these polyvalent VLPs as well as methods of making and using these VLPs.

Abstract translation: 描述了包含流感抗原多肽的多价流感病毒样颗粒（VLP）。 还描述了包含这些多价VLP的组合物以及制备和使用这些VLP的方法。

公开(公告)号：WO2016168187A1

公开(公告)日：2016-10-20

申请号：PCT/US2016/027117

申请日：2016-04-12

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： WEN, Fei ,  KHERA, Eshita ,  HILL, Brett Dallas ,  RIZVI, Syed

IPC: A61K39/12 ,  C07K14/16

CPC classification number: A61K39/12 ,  A61K39/145 ,  A61K39/21 ,  A61K2039/5258 ,  A61K2039/70 ,  C07K14/395 ,  C12N15/81 ,  C12N2740/16023 ,  C12N2740/16034 ,  C12N2760/14123 ,  C12N2760/14134 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2760/16223 ,  C12N2800/102

Abstract: Provided herein are membrane enveloped virus-like particles (VLPs), and methods of use and synthesis thereof. In particular, yeast-cell-derived VLPs are provided that comprise surface-displayed glycoproteins and/or multiple virally-derived proteins.

Abstract translation: 本文提供的是膜包膜病毒样颗粒（VLP）及其使用和合成方法。 特别地，提供了酵母细胞衍生的VLP，其包含表面显示的糖蛋白和/或多个病毒衍生的蛋白质。

公开(公告)号：WO2015195218A1

公开(公告)日：2015-12-23

申请号：PCT/US2015/029843

申请日：2015-05-08

Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES

Inventor： TAUBENBERGER, Jeffery, K.

IPC: A61K39/145

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/5258 ,  A61K2039/543 ,  A61K2039/55572 ,  A61K2039/70 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2760/16223 ,  C12N2760/16234

Abstract: This disclosure provides compositions that include a mixture of viral like particles (VLPs), expressing different individual influenza hemagglutinin (HA) proteins that elicit broadly reactive immune responses to a wide variety of influenza viruses. For example, the composition can include at least two different influenza VLPs, a first VLP comprising a first HA polypeptide and a second VLP comprising a second influenza HA polypeptide, wherein the first and the second HA polypeptide are different subtypes and/or are from different influenza viruses, and a pharmaceutically acceptable carrier and/or an adjuvant. Methods of using the disclosed polymeric influenza VLP compositions to stimulate an immune response against influenza viruses, for example as a pre-pandemic or a seasonal vaccine, are provided.

Abstract translation: 本公开提供包括病毒样颗粒（VLP）的混合物的组合物，其表达引起对多种流感病毒的广泛反应性免疫应答的不同个体流感血凝素（HA）蛋白质。 例如，组合物可以包括至少两种不同的流感VLP，包含第一HA多肽的第一VLP和包含第二流感HA多肽的第二VLP，其中第一和第二HA多肽是不同的亚型和/或不同的 流感病毒和药学上可接受的载体和/或佐剂。 提供了使用所公开的聚合物流感VLP组合物来刺激针对流感病毒的免疫应答的方法，例如作为大流行前期或季节性疫苗。

公开(公告)号：WO2010148511A8

公开(公告)日：2011-03-10

申请号：PCT/CA2010000983

申请日：2010-06-25

Applicant: MEDICAGO INC ,  COUTURE MANON ,  DARGIS MICHELE ,  LAVOIE PIERRE-OLIVIER ,  VEZINA LOUIS-PHILIPPE ,  D AOUST MARC-ANDRE

Inventor： COUTURE MANON ,  DARGIS MICHELE ,  LAVOIE PIERRE-OLIVIER ,  VEZINA LOUIS-PHILIPPE ,  D AOUST MARC-ANDRE

IPC: C07K14/11 ,  A01H5/00 ,  A61K39/145 ,  A61P31/16 ,  C07K19/00 ,  C12N7/00 ,  C12N7/01 ,  C12N15/44 ,  C12N15/82

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K2039/5258 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/02 ,  C12N15/8257 ,  C12N2760/16122 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2760/16222 ,  C12N2760/16223 ,  C12N2760/16234

Abstract: A method for synthesizing chimeric influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of chimeric influenza HA in a plant or a portion of a plant. The invention is also directed towards a VLP comprising chimeric influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding chimeric influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.

Abstract translation: 提供了一种在植物或植物的一部分内合成嵌合型流感病毒样颗粒（VLP）的方法。 该方法包括在植物或植物的一部分中表达嵌合流感HA。 本发明还涉及包含嵌合流感HA蛋白和植物脂质的VLP。 本发明还涉及编码嵌合流感HA以及载体的核酸。 VLP可用于制定流感疫苗，或可用于丰富现有疫苗。

公开(公告)号：WO2009012487A2

公开(公告)日：2009-01-22

申请号：PCT/US2008/070636

申请日：2008-07-21

Applicant: NOVAVAX, INC. ,  SMITH, Gale ,  PUSHKO, Peter

Inventor： SMITH, Gale ,  PUSHKO, Peter

IPC: A61K39/145

CPC classification number: C07K14/005 ,  A61K39/12 ,  A61K39/145 ,  A61K39/155 ,  A61K2039/5258 ,  C07K2319/00 ,  C07K2319/735 ,  C12N7/00 ,  C12N2710/14143 ,  C12N2760/16122 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2760/16222 ,  C12N2760/16223 ,  C12N2760/16234 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2770/20022 ,  C12N2770/20023 ,  C12N2770/20034 ,  C12N2800/22 ,  C12N2810/6072 ,  C12N2810/609 ,  Y02A50/386 ,  Y02A50/388

Abstract: The present invention discloses novel chimeric Varicella Zoster Virus (VZV) virus-like particles (VLPs) comprising chimeric VZV glycoproteins. The invention also discloses vaccine formulations of the chimeric VZV-VLPs and methods of inducing an immune response in subjects.

Abstract translation: 本发明公开了包含嵌合VZV糖蛋白的新型嵌合水痘带状疱疹病毒（VZV）病毒样颗粒（VLP）。 本发明还公开了嵌合VZV-VLP的疫苗制剂和在受试者中诱导免疫应答的方法。

公开(公告)号：WO2018073340A1

公开(公告)日：2018-04-26

申请号：PCT/EP2017/076705

申请日：2017-10-19

Applicant: REDBIOTEC AG ,  EUROPEAN VACCINE INITIATIVE ,  INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLÓGICA (IBET) ,  ETNA BIOTECH S.R.L. ,  BIOMEDICAL PRIMATE RESEARCH CENTRE ,  STICHTING WAGENINGEN RESEARCH (WAGENINGEN BIOVETERINARY RESEARCH (WBVR))

Inventor： REMARQUE, Edmond J.

IPC: A61K39/145 ,  A61K39/295

CPC classification number: A61K39/12 ,  A61K2039/5258 ,  A61K2039/58 ,  A61K2039/70 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2760/16223 ,  C12N2760/16234

Abstract: The present invention relates to vaccine compositions comprising at least three variants of a subtype of an influenza A and/or B virus antigen, wherein the at least three variants are selected on the basis of differences between their amino acid sequences. The present invention further relates to said vaccine compositions for use in a method of generating an immune response against influenza viruses. Further provided is a method for producing said vaccine compositions.

Abstract translation: 本发明涉及疫苗组合物，其包含至少三种流感A和/或B病毒抗原亚型的变体，其中所述至少三种变体基于其氨基之间的差异进行选择 酸序列。 本发明进一步涉及用于产生针对流感病毒的免疫应答的方法中的所述疫苗组合物。 还提供了生产所述疫苗组合物的方法。

公开(公告)号：WO2017040203A1

公开(公告)日：2017-03-09

申请号：PCT/US2016/048691

申请日：2016-08-25

Applicant: KAWAOKA, Yoshihiro ,  NEUMANN, Gabriele

Inventor： KAWAOKA, Yoshihiro ,  NEUMANN, Gabriele

IPC: A61K39/12 ,  C12N7/00

CPC classification number: C12N7/00 ,  A61K39/12 ,  A61K2039/5254 ,  C12N2760/16123 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16152 ,  C12N2760/16223 ,  C12N2760/16234 ,  C12N2760/16251 ,  C12N2760/16252

Abstract: A method is described that combines the use of two or more distinct VLPs to produce a replication - competent fully infectious influenza virus.

Abstract translation: 描述了组合使用两个或更多个不同VLP以产生复制能力的完全感染性流感病毒的方法。