公开(公告)号：WO2021206948A1

公开(公告)日：2021-10-14

申请号：PCT/US2021/024728

申请日：2021-03-29

Applicant: TEPHA, INC.

Inventor： SARIIBRAHIMOGLU, Kemal ,  LIMEM, Skander ,  RIZK, Said ,  WILLIAMS, Simon F.

IPC: A61F2/12 ,  A61N5/10 ,  A61B90/00

Abstract: Implantable fiducial marker devices with a predefined shape can deform when stress is applied in vivo, and recover their shape when stress is removed reduce patient discomfort and palpability. The devices can be used to mold irregular tumor resection cavities into a more ideal shape for radiation therapy allowing more accurate treatment. After treatment, the devices resorb eliminating unnecessary testing that occurs when clinicians are unaware of implanted fiducial marker devices. Tissue ingrowth into the devices can also result in improved cosmetic outcomes when the devices are implanted in the breast after a lumpectomy. The devices preferably comprise poly-4-hydroxybutyrate or poly(butylene succinate) or copolymers thereof.

公开(公告)号：WO2021126638A1

公开(公告)日：2021-06-24

申请号：PCT/US2020/064102

申请日：2020-12-09

Applicant: TEPHA, INC.

Inventor： SARIIBRAHIMOGLU, Kemal ,  LIMEM, Skander ,  GANATRA, Amit ,  RIZK, Said ,  WILLIAMS, Simon, F.

IPC: A61F2/28 ,  A61F2/30 ,  A61L31/06 ,  A61F2/2875 ,  A61F2/3094 ,  A61F2002/30032 ,  A61F2002/30062 ,  A61F2002/30113 ,  A61F2002/30224 ,  A61F2002/30233 ,  A61F2002/30235 ,  A61F2002/30299 ,  A61F2002/30322 ,  A61F2002/30354 ,  A61F2002/30405 ,  A61F2002/30784 ,  A61F2002/30892 ,  A61F2002/30914 ,  A61F2002/30915 ,  A61F2002/30971 ,  A61F2002/30985 ,  A61F2310/00179 ,  A61L2430/02 ,  A61L27/18 ,  A61L27/58 ,  A61L31/026 ,  A61L31/146 ,  A61L31/148 ,  C08K3/346

Abstract: Devices (200) to repair bone defects prevent the formation of depressions and palpable tissue at bone repair sites. The devices can be used to repair burr holes in the cranium, providing an improved cosmetic result that reduces or eliminates functional handicaps that can result from combing and hairdressing. The devices are secured in bone defects with filament elements (210), by expanding the device inside the bone defect, or by gluing. Tissue in-growth into the device regenerates bone at the defect site, and prevents the formation of depressions or palpable tissue. The devices preferably comprise a ceramic and poly-4-hydroxybutyrate or copolymer thereof, or a ceramic and poly (butylene succinate) or copolymer thereof.

公开(公告)号：WO2022240739A1

公开(公告)日：2022-11-17

申请号：PCT/US2022/028313

申请日：2022-05-09

Applicant: TEPHA, INC. ,  CORNELL UNIVERSITY

Inventor： LIMEM, Skander ,  SARIIBRAHIMOGLU, Kemal ,  SCOTT, Jeffrey, Robert ,  WILLIAMS, Simon, F. ,  SPECTOR, Jason

IPC: A61F2/12 ,  A61F2/00 ,  A61L27/14 ,  A61F2/0059 ,  A61F2/0063 ,  A61F2210/0004 ,  A61F2230/0093 ,  A61F2240/001 ,  A61F2250/0023 ,  A61F2250/0067 ,  A61L2430/04 ,  A61L27/18 ,  A61L27/56

Abstract: Absorbable 3D printed implants can be used to reconstruct the nipple with regenerated tissue resulting in improved aesthetic satisfaction. The implants are formed from parallel planes of filaments that are offset and bonded to each other to form macroporous networks (130) with open cell structures comprising cylindrical shapes. The macroporous network (130) may be enclosed by a shell (120) or coating, or may be at least partly filled with a hydrogel. The implants are particularly suitable for use in plastic surgery procedures, for example, to reconstruct the nipple following total mastectomy and breast reconstruction.

公开(公告)号：WO2022240725A1

公开(公告)日：2022-11-17

申请号：PCT/US2022/028284

申请日：2022-05-09

Applicant: TEPHA, INC.

Inventor： LIMEM, Skander ,  SARIIBRAHIMOGLU, Kemal ,  SCOTT, Jeffrey Robert ,  WILLIAMS, Simon, F.

IPC: A61F2/12 ,  A61F2/00 ,  A61L27/14 ,  A61F2/0059 ,  A61F2/0063 ,  A61F2210/0004 ,  A61F2230/0093 ,  A61F2240/001 ,  A61F2250/0023 ,  A61F2250/0067 ,  A61L2430/04 ,  A61L27/18 ,  A61L27/56

Abstract: Absorbable implants can be used to reconstruct the nipple with regenerated tissue resulting in improved aesthetic satisfaction. The implants are particularly suitable for use in plastic surgery procedures, for example, to reconstruct the nipple following total mastectomy and breast reconstruction. The implants may be formed from absorbable mesh and/or dry spun sheet.

公开(公告)号：WO2022225798A1

公开(公告)日：2022-10-27

申请号：PCT/US2022/024954

申请日：2022-04-15

Applicant: TEPHA, INC.

Inventor： LIMEM, Skander ,  SARIIBRAHIMOGLU, Kemal ,  BUTLER, Timothy, John ,  WILLIAMS, Simon, F.

IPC: A61F2/12 ,  B33Y80/00 ,  A61L27/56 ,  A61L27/58

Abstract: Absorbable implants can be used to create volume and shape in the breast of a patient with regenerated tissue. The implants are transient comprising a reinforced matrix comprising a load bearing absorbable macroporous network with an open pore structure, at least partially filled with one or more degradable hydrogels or water-soluble polymers that degrade progressively, from the surface of the implant towards the core of the implant, and direct tissue ingrowth in the same direction. The hydrogels and water-soluble polymers help prevent fluid accumulation in the implant prior to tissue ingrowth. The macroporous networks are absorbed after tissue ingrowth has occurred, and a load bearing support is no longer necessary. The implants are particularly suitable for use in plastic surgery procedures, for example, to regenerate or augment breast tissue following mastectomy or in mastopexy procedures, and can provide an alternative to the use of permanent breast implants in these procedures.