公开(公告)号：WO2021154985A1

公开(公告)日：2021-08-05

申请号：PCT/US2021/015475

申请日：2021-01-28

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： FAN, Xudong ,  WANG, Xueding ,  LI, Xuzhou ,  ZHANG, Wei ,  WANG, William Yanli ,  WU, Xiaoqin ,  TAN, Xiaotian ,  BAKER, Brendon ,  PAULUS, Yannis M.

IPC: G01N21/64 ,  G01N21/62 ,  G01N21/63

Abstract: An imaging system for cell-based therapies is provided. The imagining system includes one or more optical tags configured for insertion into a cell or biological tissue, an excitation light source configured to illuminate the one or more optical tags; a detector configured to measure optical emission of the one or more optical tags; an imaging subsystem configured to determine a three-dimensional location of each of the one or more optical tags in the cell or biological tissue; and a controller in electrical communication with the excitation light source, the detector, and the imaging subsystem. Each of the one or more optical tags has a contrasting feature and includes a fluorescent material. The contrasting feature may be defined by at least one of a refractive index, shape, color, and laser emission of each optical tag of the one or more optical tags.