公开(公告)号：WO2010065551A3

公开(公告)日：2010-06-10

申请号：PCT/US2009/066276

申请日：2009-12-01

Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK ,  SITHARAMAN, Balaji ,  GREEN, Danielle, E. ,  LONGTIN, Jon

Inventor： SITHARAMAN, Balaji ,  GREEN, Danielle, E. ,  LONGTIN, Jon

IPC: A01K67/00 ,  C12N5/0775

Abstract: A method for differentiating mesenchymal stem cells (MSCs) towards osteoblasts and other connective tissue using nanoparticles and electromagnetic stimulation Osteoinductive materials produced using said method may be useful for bone regeneration and reconstruction in treatment of bone trauma and bone related diseases, and to correct birth defects.

公开(公告)号：WO2012170909A1

公开(公告)日：2012-12-13

申请号：PCT/US2012/041689

申请日：2012-06-08

Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK ,  SITHARAMAN, Balaji

Inventor： SITHARAMAN, Balaji

IPC: C12N13/00

CPC classification number: A61K41/0047 ,  A61N1/40 ,  A61N5/062 ,  A61N7/00 ,  A61N2005/0651 ,  A61N2005/0659 ,  A61N2005/067 ,  A61N2007/0013

Abstract: The present invention provides a method for non-invasive acoustic stimulation of stem cells and/or progenitor cells in a patient. The invention also provides a device for non-invasive stimulation of stem cells and/or progenitor cells in the patient by generating and delivering acoustic waves of a suitable frequency and intensity to the stem cells and/or progenitor cells. The method and device of the present invention is useful in enhancing regeneration of bones and other tissues, such as cartilages, muscles, and nerve tissues, in a patient, for treatment of conditions such as bone loss or facture.

Abstract translation: 本发明提供了一种用于患者中干细胞和/或祖细胞的非侵入性声刺激的方法。 本发明还提供了一种用于通过产生和递送对干细胞和/或祖细胞的合适频率和强度的声波来非侵入性地刺激患者中的干细胞和/或祖细胞的装置。 本发明的方法和装置可用于增强患者骨骼和其他组织如软骨，肌肉和神经组织的再生，用于治疗诸如骨丢失或生成的病症。

公开(公告)号：WO2013152144A1

公开(公告)日：2013-10-10

申请号：PCT/US2013/035190

申请日：2013-04-04

Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK

Inventor： SITHARAMAN, Balaji ,  LALWANI, Gaurav

IPC: C01B31/02 ,  B82B1/00 ,  B82Y40/00

CPC classification number: C01B32/05 ,  B82Y30/00 ,  C01B32/15 ,  C01B32/158 ,  C01B32/16 ,  C01B32/168 ,  C01B2202/02 ,  C01B2202/06 ,  C01B2202/22 ,  C01P2004/61 ,  C01P2006/16 ,  Y10S977/742 ,  Y10S977/751 ,  Y10S977/752 ,  Y10T428/2982

Abstract: The method of the present disclosure is directed towards the formation of a three-dimensional carbon structure and includes the steps of adding a radical initiator to an amount of carbon starting material, forming a mixture, placing the mixture in a mold, maintaining the mixture and the mold at an elevated temperature for a period of time to form a thermally cross-linked molded mixture and removing the thermally cross-linked molded mixture from the mold. The disclosure also includes a three-dimensional carbon structure, with that structure including a thermally cross-linked carbon base material in a predetermined formation.

Abstract translation: 本公开的方法涉及三维碳结构的形成，包括以下步骤：向一定量的碳原料添加自由基引发剂，形成混合物，将混合物置于模具中，保持混合物和 模具在高温下一段时间以形成热交联的模制混合物并从模具中除去热交联的模制混合物。 本公开还包括三维碳结构，其结构包括在预定形式中的热交联碳基材料。

公开(公告)号：WO2012154677A1

公开(公告)日：2012-11-15

申请号：PCT/US2012/036790

申请日：2012-05-07

Applicant: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK ,  SITHARAMAN, Balaji ,  PARATALA, Bhavna, S.

Inventor： SITHARAMAN, Balaji ,  PARATALA, Bhavna, S.

IPC: B32B9/00

CPC classification number: A61K49/10 ,  A61K49/0095 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B31/0446 ,  C01B31/0476 ,  C01B32/184 ,  C01B32/192 ,  C01B2204/20

Abstract: A magnetic graphene-like nanoparticle or graphitic nano- or microparticle exhibits a high relaxivity, and is useful as a MRI contrast agent. A composition for use with MRI imaging, comprising a sufficient amount of the magnetic graphene-like nanoparticles or graphitic nano- or microparticles and one or more physiologically acceptable carriers or excipients. Methods of using the magnetic graphene-like nanoparticles or graphitic nano- or microparticles as MRI contrast agents. Methods of producing the magnetic graphene-like nanoparticle or graphitic nano- or microparticle.

Abstract translation: 磁性石墨烯纳米颗粒或石墨纳米颗粒或微粒表现出高的弛豫性，并且可用作MRI造影剂。 用于MRI成像的组合物，其包含足够量的磁性石墨烯纳米颗粒或石墨纳米微粒和一种或多种生理上可接受的载体或赋形剂。 使用磁性石墨烯纳米颗粒或石墨纳米颗粒或微粒作为MRI造影剂的方法。 制造磁性石墨烯纳米颗粒或石墨纳米颗粒或微粒的方法。