公开(公告)号：WO2021041865A1

公开(公告)日：2021-03-04

申请号：PCT/US2020/048481

申请日：2020-08-28

申请人： THE SECANT GROUP, LLC

发明人： HARRIS, Jeremy J. ,  ELY, Jared ,  TASCAN, Mevlut ,  GABRIELE, Peter D. ,  CRUMBLING, Todd

IPC分类号： A61L31/04 ,  A61L31/14

摘要： An article includes a fibrous mat of poly(glycerol sebacate) (PGS) resin and a resin of a hydrogel forming polymer, such as a polyvinyl alcohol (PVOH). Methods of making such articles include electrospinning a combination of PGS resin and PVOH resin to form nanofibers and depositing the nanofibers onto a surface to form the fibrous mat. The mat is suitable for a variety of medical uses, including as a barrier that can be deployed in surgical procedures.

公开(公告)号：WO2020041489A1

公开(公告)日：2020-02-27

申请号：PCT/US2019/047533

申请日：2019-08-21

申请人： THE SECANT GROUP, LLC

发明人： REED, Stephanie ,  SMOOT, Carissa ,  SHULL, Dennis ,  CRUMBLING, Todd ,  D'OTTAVIO, John ,  GABRIELE, Peter D. ,  HARRIS, Jeremy J. ,  NICHOLSON, Charles Brendan ,  ELY, Jared

IPC分类号： A61K9/20 ,  A61K31/522 ,  A61K47/34

摘要： A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.

公开(公告)号：WO2019152582A1

公开(公告)日：2019-08-08

申请号：PCT/US2019/015948

申请日：2019-01-31

申请人： THE SECANT GROUP, LLC

发明人： HARRIS, Jeremy J. ,  NICHOLSON, Charles Brendan ,  GABRIELE, Peter D. ,  ELY, Jared ,  GINN, Brian

IPC分类号： A61L27/18 ,  A61L27/48 ,  A61L27/56

CPC分类号： A61K47/593 ,  A61K47/34 ,  A61L24/06 ,  A61L27/18 ,  A61L27/48 ,  A61L27/56 ,  A61L2400/08 ,  A61L2430/02 ,  A61P19/00 ,  C08G63/12 ,  C08J3/12 ,  C08J2367/02 ,  C08K3/013 ,  C08L67/00

摘要： A bone filling composition includes a bone filler. The bone filler includes microparticles of at least one elastomeric material. The at least one elastomeric material includes a poly(glycerol sebacate)-based thermoset. The poly(glycerol sebacate)-based thermoset may be porous thermoset poly(glycerol sebacate) flour, thermoset poly(glycerol sebacate) microspheres, or a combination thereof. In some embodiments, the bone filling composition is a bone filling composite that further includes a carrier material including a poly(glycerol sebacate) resin. A method of forming a bone filling composite includes selecting a bone filler and mixing the bone filler with a carrier material to form the bone filling composite. A method of treating a bony defect includes molding a bone filling composite and placing the bone filling composite in the bony defect. The bone filling composite includes a bone filler mixed with a carrier material.

公开(公告)号：WO2016196719A2

公开(公告)日：2016-12-08

申请号：PCT/US2016/035400

申请日：2016-06-02

申请人： THE SECANT GROUP, LLC

发明人： GABRIELE, Peter D. ,  ELY, Jared ,  HARRIS, Jeremy J.

IPC分类号： A61K41/00 ,  A61P35/00 ,  C08G63/78

CPC分类号： A61K41/0052 ,  A61K47/34 ,  A61N1/403 ,  A61N5/025 ,  C08G63/12 ,  C08G63/914

摘要： A method of cancer hyperthermia therapy includes placing a device including an exogenously-excitable polymeric material at a cancer hyperthermia therapy site of a patient. The method also includes supplying an exogenous energy to the device such that the exogenous energy excites the exogenously-excitable polymeric material at the cancer hyperthermia therapy site to heat the cancer hyperthermia therapy site to a hyperthermia temperature. A method of preparing a polymeric material includes combining an alcohol monomer, a seed of the polymeric material, and an aqueous liquid in a vessel. The method also includes adding an acid monomer to the vessel and supplying an exogenous energy to the vessel. The polymeric material is exogenously excited by the exogenous energy to heat the polymeric material. The method further includes removing water from the vessel and producing the polymeric material, which is a polyester, in the vessel.

摘要翻译： 癌症高热疗法的方法包括在患者的癌症高热治疗部位放置包含可外源性兴奋的聚合物材料的装置。 该方法还包括向装置提供外源能量，使得外源能量在癌症高热治疗部位激发外源性兴奋性聚合物材料，以将癌症高热治疗部位加热至高热温度。 制备聚合物材料的方法包括将醇单体，聚合物材料的种子和容器中的含水液体混合。 该方法还包括向容器中加入酸单体并向容器提供外源能量。 聚合材料被外源能量外部激发以加热聚合材料。 该方法还包括从容器中除去水并在容器中产生作为聚酯的聚合物材料。