公开(公告)号：WO1987005395A1

公开(公告)日：1987-09-11

申请号：PCT/US1987000400

申请日：1987-02-24

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY ...

Inventor： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY ... ,  SCHACHTER, David ,  KOWARSKI, Szloma ,  COWEN, Lisa, A. ,  ABBOTT, Richard, E.

IPC: G01N33/53

CPC classification number: C07K16/28 ,  A61K39/00 ,  C07K14/705 ,  C12Q1/6883 ,  Y10S436/804 ,  Y10S436/811 ,  Y10T436/25

Abstract: A method for detecting the presence in a human of an integral membrane calcium-binding protein associated with essential hypertension which comprises isolating tissue from a human, treating the tissue to obtain integral membrane proteins, contacting the proteins thus obtained with a first antibody molecule which binds to the integral membrane calcium binding protein to form a detectable protein-antibody complex, and detecting the complex so formed. Further, methods for quantitatively determining the amount of an integral membrane calcium-binding protein and the messenger RNA encoding said protein, diagnostic methods for identifying individuals predisposed to essential hypertension, and protein and messenger RNA associated with said hypertension.