公开(公告)号：WO2016081619A1

公开(公告)日：2016-05-26

申请号：PCT/US2015/061373

申请日：2015-11-18

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： CORNISH, Virginia, Wood ,  OSTROV, Nili ,  JIMENEZ, Miguel ,  BILLERBECK, Sonja

IPC: C12Q1/02 ,  C12N15/09 ,  G01N33/566

CPC classification number: G01N33/566 ,  C12Q1/005 ,  C12Q1/02 ,  C12Q1/025 ,  C12Q1/06 ,  G01N33/5023 ,  G01N33/5038 ,  G01N33/569 ,  G01N33/56911 ,  G01N33/56916 ,  G01N33/5695 ,  G01N33/56961 ,  G01N33/74 ,  G01N2333/726

Abstract: The present invention provides sensor cells comprising a receptor that binds to an analyte indicative of the presence of an agent, where binding of the analyte to the receptor triggers a detection event that is indicative of the presence of the agent. In certain embodiments, the detection event is appearance of a reporter detectable by the naked eye. The present invention also provides uses of such sensor cells for detecting the presence of an agent in a sample.

Abstract translation: 本发明提供了包含受体的传感器细胞，所述受体结合指示试剂存在的分析物，其中分析物与受体的结合触发指示试剂存在的检测事件。 在某些实施方案中，检测事件是肉眼可检测的报告人的外观。 本发明还提供了这种传感器电池用于检测样品中药剂的存在的用途。