公开(公告)号：WO2019236141A1

公开(公告)日：2019-12-12

申请号：PCT/US2019/013280

申请日：2019-01-11

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： JARROLD, Martin F.

IPC: H01J49/42

Abstract: A system for trapping ions for measurement thereof may include an electrostatic linear ion trap (ELIT), a source of ions to supply ions to the ELIT, a processor operatively coupled to ELIT, and a memory having instructions stored therein executable by the processor to produce at least one control signal to open the ELIT to allow ions supplied by the source of ions to enter the ELIT, determine an ion inlet frequency corresponding to a frequency of ions flowing from the source of ions into the open ELIT, generate or receive a target ion charge value, determine an optimum threshold value as a function of the target ion charge value and the determined ion inlet frequency, and produce at least one control signal to close the ELIT when a charge of an ion within the ELIT exceeds the optimum threshold value to thereby trap the ion in the ELIT.

公开(公告)号：WO2021072186A1

公开(公告)日：2021-04-15

申请号：PCT/US2020/054975

申请日：2020-10-09

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： BROWN, Brooke A. ,  CLEMMER, David E. ,  JARROLD, Martin F.

IPC: B01D50/00 ,  B01D59/44 ,  B01D59/46 ,  G01N27/62 ,  H01J3/40 ,  H01J49/26

Abstract: A method for purifying particles generates charged particles from a sample, measures at least at least one of masses, charge magnitudes and mobilities of the generated charged particles, and selectively passes to a particle collection target each of the measured charged particles having at least one of (a) a measured mass equal to a selected mass or within a selected range of particle masses, (b) a measured charge magnitude equal to a selected charge magnitude or within a selected range of charge magnitudes, (c) a mass-to-charge ratio equal to a selected mass-to-charge ratio or within a selected range of mass-to-charge ratios, and (d) a measured mobility equal to a selected mobility or within a selected range of mobilities. In some embodiments, the collected particles may be harvested and amplified.

公开(公告)号：WO2019236574A1

公开(公告)日：2019-12-12

申请号：PCT/US2019/035381

申请日：2019-06-04

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： JARROLD, Martin F. ,  ALEXANDER, Andrew W. ,  TODD, Aaron R.

IPC: H01J49/02 ,  H01J49/42

Abstract: A CDMS may include an ELIT having a charge detection cylinder (CD), a charge generator for generating a high frequency charge (HFC), a charge sensitive preamplifier (CP) having an input coupled to the CD and an output configured to produce a charge detection signal (CHD) in response to a charge induced on the CD, and a processor configured to (a) control the charge generator to induce an HFC on the CD, (b) control operation of the ELIT to cause a trapped ion to oscillate back and forth through the CD each time inducing a charge thereon, and (c) process CHD to (i) determine a gain factor as a function of the HFC induced on the CD, and (ii) modify a magnitude of the portion of CHD resulting from the charge induced on the CD by the trapped ion passing therethrough as a function of the gain factor.

公开(公告)号：WO2020117292A1

公开(公告)日：2020-06-11

申请号：PCT/US2019/013285

申请日：2019-01-11

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： JARROLD, Martin F. ,  BOTAMANENKO, Daniel

IPC: H01J49/02 ,  H01J49/42

Abstract: A charge detection mass spectrometer may include an ion source, an electrostatic linear ion trap (ELIT) including a charge detection cylinder disposed between a pair of coaxially aligned ion mirrors, means for selectively establishing electric fields within the ion mirrors configured to cause the trapped ions in the ELIT to oscillate back and forth between the ion mirrors each time passing through the charge detection cylinder, and means for controlling a trajectory of the beam of ions entering the ELIT to cause the subsequently trapped ions to oscillate with different planar ion oscillation trajectories angularly offset from one another about the longitudinal axis with each extending along and crossing the longitudinal axis in each of the ion mirrors or with different cylindrical ion oscillation trajectories radially offset from one another about the longitudinal axis to form nested cylindrical trajectories each extending along the longitudinal axis.

公开(公告)号：WO2019236572A1

公开(公告)日：2019-12-12

申请号：PCT/US2019/035379

申请日：2019-06-04

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： JARROLD, Martin F. ,  ANTHONY, Staci N. ,  DRAPER, Benjamin E.

IPC: H01J49/06

Abstract: An interface transports ions from a first pressure environment to a lower pressure analysis instrument and may include a first region pumped to a second pressure less than the first pressure, a first ion funnel disposed in the first region, a first ion carpet in the first region opposite an ion outlet end of the first ion funnel, a second region pumped to a third pressure less than the second pressure and greater than the instrument pressure, a second ion funnel disposed in the second region and a second ion carpet in the second region opposite an ion outlet end of the second ion funnel. Ions from the environment pass sequentially through the first and second ion funnels and into the analysis instrument. Each of the first and second ion funnels define a tapered axial passageway therethrough each defining a respective virtual jet disrupter therein.

公开(公告)号：WO2019236143A1

公开(公告)日：2019-12-12

申请号：PCT/US2019/013284

申请日：2019-01-11

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： JARROLD, Martin F. ,  ALEXANDER, Andrew W. ,  TODD, Aaron R.

IPC: H01J49/02 ,  H01J49/42

Abstract: A charge detection mass spectrometer (CDMS) including charge detector reset or calibration may include an electrostatic linear ion trap (ELIT) having a charge detection cylinder disposed between first and second ion mirrors, a charge generator for generating free charges, a field free region between the charge generator and the charge detection cylinder, and a processor configured to control the charge generator to generate a target number of free charges and cause the target number of free charges to travel across the field-free region and into contact with the charge detection cylinder to deposit the target number of free charges thereon and thereby calibrate or reset the charge detection cylinder to a corresponding target charge level.

公开(公告)号：WO2019236139A1

公开(公告)日：2019-12-12

申请号：PCT/US2019/013274

申请日：2019-01-11

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： JARROLD, Martin F. ,  ANTHONY, Staci N. ,  DRAPER, Benjamin E.

IPC: H01J49/06

Abstract: An interface transports ions from an atmospheric pressure environment to a low pressure environment and may include an ion funnel having a plurality spaced-apart, sealed together ring electrodes together defining an axial passageway therethrough. Ions enter a first end of the axial passageway and exit at an ion exit at a second end thereof. An ion carpet spaced apart from the ion exit is sealed to the ion funnel, and defines an ion outlet of the interface. The axial passageway defines a drift region adjacent to the first end thereof and a funnel region between the drift region and the ion exit. The funnel region has a cross-sectional area that tapers from a first cross-sectional area adjacent to the drift region to a second reduced cross-sectional area at the ion exit. The tapered axial passageway of the funnel region defines a virtual jet disrupter therein.

公开(公告)号：WO2021158676A1

公开(公告)日：2021-08-12

申请号：PCT/US2021/016435

申请日：2021-02-03

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： JARROLD, Martin F. ,  BOTAMANENKO, Daniel

IPC: H01J49/42 ,  H01J49/02

Abstract: A charge detection mass spectrometer (CDMS) includes an electrostatic linear ion trap (ELIT), a processor, and a memory having instructions stored therein executable by the processor to (a) control the ELIT to trap an ion, (b) collect ion measurement information as the trapped ion oscillates back and forth through the ELIT, the ion measurement information including charge induced by the ion on a charge detector of the ELIT during each pass of the ion through the ELIT and timing of the induced charges relative to one another, (c) process the ion measurement information in the time-domain for each of a plurality of sequential time windows of the ion measurement information to determine a charge magnitude of the ion during each time window, and (d) determine the magnitude of charge of the trapped ion based on the charge magnitudes of each of the time windows.

公开(公告)号：WO2021061650A1

公开(公告)日：2021-04-01

申请号：PCT/US2020/052009

申请日：2020-09-22

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： JARROLD, Martin F. ,  TODD, Aaron R.

IPC: H01J49/42 ,  H01J49/40

Abstract: A charge detection mass spectrometer includes an ion trap configured to receive and store ions therein and to selectively release stored ions therefrom, and an electrostatic linear ion trap (ELIT) spaced apart from the ion trap, the ELIT including first and second ion mirrors and a charge detection cylinder positioned therebetween, and means for selectively controlling the ion trap to release at least some of the stored ions therefrom to travel toward and into the ELIT, and for controlling the first and second ion mirrors in a manner which traps in the ELIT a single one of the ions traveling therein and causes the trapped ion to oscillate back and forth between the first and second ion mirrors each time passing through and inducing a corresponding charge on the charge detection cylinder.

公开(公告)号：WO2019236140A1

公开(公告)日：2019-12-12

申请号：PCT/US2019/013277

申请日：2019-01-11

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： JARROLD, Martin F. ,  DRAPER, Benjamin E.

IPC: H01J49/42 ,  H01J49/02

Abstract: A charge detection mass spectrometer may include an electrostatic linear ion trap (ELIT) or an orbitrap, an ion source to supply ions thereto, at least one amplifier operatively coupled to the ELIT or orbitrap, a processor coupled to ELIT or orbitrap and to the amplifier(s), and processor programmed to control the ELIT or orbitrap as part of a trapping event to attempt to trap therein a single ion supplied by the ion source, to record ion measurement information based on output signals produced by the amplifier(s) over a duration of the trapping event, to determine, based on the measurement information, whether the control of the ELIT or orbitrap resulted in trapping of a single ion, no ion or multiple ions, and to compute an ion mass or mass-to-charge ratio from the measurement information only if a single ion was trapped during the trapping event.