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    IDENTIFICATION OF PNEUMOCYSTIS ANTIGENS AND USES THEREOF
    3.
    发明申请
    IDENTIFICATION OF PNEUMOCYSTIS ANTIGENS AND USES THEREOF 审中-公开
    肺炎球菌抗原的鉴定及其用途

    公开(公告)号：WO2015143220A1

    公开(公告)日：2015-09-24

    申请号：PCT/US2015/021573

    申请日：2015-03-19

    Applicant: KOLLS, Jay Kennedy ,  ZHENG, Mingquan Michael ,  CAI, Yang ,  EDDENS, Taylor John ,  RICKS, David M.

    Inventor： KOLLS, Jay Kennedy ,  ZHENG, Mingquan Michael ,  CAI, Yang ,  EDDENS, Taylor John ,  RICKS, David M.

    IPC: A61K38/00 ,  A61K39/395 ,  A61P31/10 ,  G01N33/53 ,  C07K14/39 ,  C12N15/31

    CPC classification number: A61K39/0002 ,  A61K38/00 ,  C07K14/37 ,  C07K14/39 ,  C12Q1/689 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N33/56961 ,  G01N33/6893 ,  G01N2333/37 ,  G01N2800/26

    Abstract: Pneumonia due to the fungus Pneumocystis jirovecii is a life-threatening infection that occurs in immunocompromised patients. The inability to culture the organism as well as the lack of a sequenced genome has hindered antigen discovery that could be useful in developing effective vaccines, therapeutic antibodies and diagnostic methods. A method of surface proteomics of Pneumocystis murina that reliably detects surface proteins that are conserved in Pneumocystis jirovecii is described. In particular, eight identified P. murina surface proteins are described, including MeulO, GSC-1, Ght5, Erg6, ATP2, Gas4, and Mfsl. Methods of eliciting immune responses against the identified proteins, generating therapeutic antibodies against the identified proteins, as well as diagnostic methods based on the identified peptides are described.

    Abstract translation: 由真菌导致的肺炎肺炎支原体是一种危及生命的感染，发生在免疫功能低下的患者中。 无法培养生物体以及缺乏测序的基因组阻碍了抗原的发现，可用于开发有效的疫苗，治疗性抗体和诊断方法。 描述了可靠地检测在肺孢子菌中保守的表面蛋白质的肺孢子虫的表面蛋白质组学方法。 特别地，描述了八种鉴定的P. murina表面蛋白，包括MeulO，GSC-1，Ght5，Erg6，ATP2，Gas4和Mfs1。 描述了针对所鉴定的蛋白质引起免疫应答，产生针对所鉴定的蛋白质的治疗性抗体的方法以及基于鉴定的肽的诊断方法。

    METHODS OF ASSESSING THE SUITABILITY OF TRANSDUCED T CELLS FOR ADMINISTRATION
    4.
    发明申请
    METHODS OF ASSESSING THE SUITABILITY OF TRANSDUCED T CELLS FOR ADMINISTRATION 审中-公开
    评估转导性T细胞适用性的方法

    公开(公告)号：WO2014011996A1

    公开(公告)日：2014-01-16

    申请号：PCT/US2013/050287

    申请日：2013-07-12

    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

    Inventor： JUNE, Carl, H. ,  LEVINE, Bruce, L. ,  KALOS, Michael, D.

    IPC: C07K14/705

    CPC classification number: A61K35/17 ,  C07K16/2803 ,  C07K2317/622 ,  C12Q1/04 ,  C12Q1/701 ,  C12Q2600/158 ,  G01N33/569 ,  G01N33/56933 ,  G01N33/56983 ,  G01N33/92 ,  G01N2333/195 ,  G01N2333/37 ,  G01N2400/50

    Abstract: The invention relates to of analyzing vector supernatants useful for transducing T cells destined for administration to a human subject. The invention also related to methods of analyzing transduced T cells destined for administration to a human subject. The invention provides a method of analyzing a genetically modified T cell to detect a contaminant, wherein the genetically modified T cell comprises a nucleic acid encoding a chimeric antigen receptor (CAR), wherein the CAR comprises an antigen binding domain, a transmembrane' domain, a costimulatory signaling region, and a signaling domain. In one embodiment, the contaminant is at least one selected from the group consisting of endotoxin, mycoplasma, replication competent lentivirus (RCL), p24, VSV-G nucleic acid, HN gag, residual anti-CD3/anti-CD28 coated beads, mouse antibodies, pooled human serum, bovine serum albumin, bovine serum, culture media components, vector packaging cell or plasmid components, a bacterium and a fungus.

    Abstract translation: 本发明涉及分析用于转导注射给人受试者的T细胞的载体上清液。 本发明还涉及分配用于给予受试者的转导性T细胞的方法。 本发明提供了分析遗传修饰的T细胞以检测污染物的方法，其中所述经遗传修饰的T细胞包含编码嵌合抗原受体（CAR）的核酸，其中所述CAR包含抗原结合结构域，跨膜结构域， 共刺激信号区和信号结构域。 在一个实施方案中，污染物是选自由内毒素，支原体，复制感受态慢病毒（RCL），p24，VSV-G核酸，HN gag，残留的抗CD3 /抗CD28包被的珠粒，小鼠 抗体，合并的人血清，牛血清白蛋白，牛血清，培养基组分，载体包装细胞或质粒组分，细菌和真菌。

    EXTRACTION OF MYCOTOXINS
    6.
    发明申请
    EXTRACTION OF MYCOTOXINS 审中-公开
    提取MYCOTOXINS

    公开(公告)号：WO2013116847A1

    公开(公告)日：2013-08-08

    申请号：PCT/US2013/024650

    申请日：2013-02-04

    Applicant: CHARM SCIENCES, INC.

    Inventor： JABOUR, John ,  SAUL, Steven, J. ,  TESS, Mark, E.

    IPC: G01N33/53 ,  G01B11/00 ,  C12Q1/06

    CPC classification number: G01N1/34 ,  G01N1/4055 ,  G01N33/10 ,  G01N33/54366 ,  G01N33/56961 ,  G01N2001/4061 ,  G01N2333/37 ,  Y10T436/25375

    Abstract: A method and composition for extracting an analyte from a test sample such as grain, so as to determine whether the test sample is contaminated with a toxin. The method is particularly useful for detecting the presence in a batch of grain of a mycotoxin, such as for example aflatoxin, ochratoxin, T2, zearalanone, vomitoxin (deoxynivalenol a/k/a DON), patulin and fumonisin. Extraction is performed with use of a composition that includes a proteinaceous material, such as albumin, as an extraction agent.

    Abstract translation: 一种用于从诸如谷物的测试样品中提取分析物的方法和组合物，以便确定测试样品是否被毒素污染。 该方法特别可用于检测一批霉菌毒素（例如黄曲霉毒素，赭曲霉毒素，T2，泽西拉酮，呕吐毒素（脱氧雪腐镰刀菌烯醇a / k / a DON），patulin和伏马菌素）的存在。 使用包含蛋白质物质如白蛋白的组合物作为提取剂进行提取。

    METHODS FOR DETECTION OF FUNGAL DISEASE
    7.
    发明申请
    METHODS FOR DETECTION OF FUNGAL DISEASE 审中-公开
    检测真菌病的方法

    公开(公告)号：WO2007038568A1

    公开(公告)日：2007-04-05

    申请号：PCT/US2006/037607

    申请日：2006-09-26

    Applicant: TEOTTEN DIAGNOSTICS, INC. ,  SHUSTER, Jeffrey, R., Ph., D.

    Inventor： SHUSTER, Jeffrey, R., Ph., D.

    IPC: G01N33/53

    CPC classification number: C12Q1/04 ,  C12Q1/26 ,  G01N2333/37

    Abstract: The present invention describes the use of enzymes having D-arabinitol oxidase activity with the concomitant generation of hydrogen peroxide for the diagnosis of fungal infections of humans and other organisms, and for the detection of fungal organisms that are present on or in surfaces or permeable materials. The present invention also describes methods and kits for the detection of fungi, and the diagnosis of fungal infections based upon D-arabinitol oxidase activity. The present invention also provides a new biochemical activity for gene products encoded by bacterial genes previously identified only with putative function. Activity of these gene products includes the ability to oxidize D-arabinitol with the concomitant generation of hydrogen peroxide.

    Abstract translation: 本发明描述了具有D-阿拉伯糖醇氧化酶活性的酶与伴随产生过氧化氢的酶用于诊断人和其他生物体的真菌感染的用途，以及用于检测存在于或表面上的真菌生物或可渗透材料 。 本发明还描述了用于检测真菌的方法和试剂盒，以及基于D-阿拉伯糖醇氧化酶活性的真菌感染的诊断。 本发明还提供了由以前仅用推定功能鉴定的细菌基因编码的基因产物的新的生化活性。 这些基因产物的活性包括伴随产生过氧化氢氧化D-阿拉伯糖醇的能力。

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