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    BISTRIFILATE-BASED FLUOROGENIC PROBES FOR DETECTION OF SUPEROXIDE ANION RADICAL
    4.
    发明申请
    BISTRIFILATE-BASED FLUOROGENIC PROBES FOR DETECTION OF SUPEROXIDE ANION RADICAL 审中-公开
    用于检测超氧化物阴离子辐射的基于双歧杆菌的荧光探针

    公开(公告)号：WO2015113455A1

    公开(公告)日：2015-08-06

    申请号：PCT/CN2015/000072

    申请日：2015-01-30

    申请人： THE UNIVERSITY OF HONG KONG

    发明人： YANG, Dan ,  HU, Jun ,  WONG, Nai Kei

    IPC分类号： C07D407/02 ,  C07F7/10 ,  C07F7/08 ,  B41M5/327 ,  B41M5/20

    CPC分类号： G01N33/84 ,  C07D311/82 ,  C07D491/20 ,  C07D493/10 ,  C07F7/0816 ,  C07F9/6561 ,  G01N33/582

    摘要： The invention provides fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening superoxide. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. The invention further provides fluorogenic compounds for selectively staining superoxide in the mitochondria of living cells. The invention also provides methods that can be used to measure, directly or indirectly, the presence and/or amount of superoxide in chemical samples and biological samples such as cells and tissues in living organisms, and a high-throughput screening methods for detecting or screening superoxide or compounds that can increase or decrease the level of superoxide in chemical and biological samples.

    摘要翻译： 本发明提供可用作测量，检测和/或筛选超氧化物的试剂的荧光化合物和探针。 本发明的荧光化合物可以产生荧光颜色，例如绿色，黄色，红色或远红色。 本发明还提供了用于选择性染色活细胞线粒体中超氧化物的荧光化合物。 本发明还提供了可用于直接或间接测量化学样品和生物样品如生物体中的细胞和组织的超氧化物的存在和/或量的方法，以及用于检测或筛选的高通量筛选方法 超氧化物或可增加或降低化学和生物样品中超氧化物水平的化合物。

    DIARYLAMINE-BASED FLUOROGENIC PROBES FOR DETECTION OF PEROXYNITRITE
    5.
    发明申请
    DIARYLAMINE-BASED FLUOROGENIC PROBES FOR DETECTION OF PEROXYNITRITE 审中-公开
    用于检测过氧硝酸的基于二氨基胺的荧光探针

    公开(公告)号：WO2013113279A1

    公开(公告)日：2013-08-08

    申请号：PCT/CN2013/071155

    申请日：2013-01-30

    申请人： THE UNIVERSITY OF HONG KONG

    发明人： YANG, Dan ,  PENG, Tao ,  SHEN, Jiangang ,  CHEN, Xingmiao

    IPC分类号： C07D407/02 ,  C09K3/00 ,  B41M5/327 ,  B41M5/20

    CPC分类号： G01N31/227 ,  C07D311/82 ,  C07D311/90 ,  C07D491/052 ,  C07D493/10 ,  C07D493/20 ,  C07F7/0816 ,  C07F9/6561 ,  C09B11/08 ,  C09B11/24 ,  C09B11/245 ,  C09B69/008 ,  G01N33/582 ,  G01N33/84 ,  Y10T436/170769

    摘要： Provided herein are improved fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening peroxynitrite. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. Also provided herein are fluorogenic compounds for selectively staining peroxynitrite in the mitochondria of living cells. Provided also herein are methods that can be used to measure, directly or indirectly, the presence and/or amount of peroxynitrite in chemical samples and biological samples such as cells and tissues in living organisms. Also provided are high- throughput screening methods for detecting or screening peroxynitrite or compounds that can increase or decrease the level of peroxynitrite in chemical and biological samples.

    摘要翻译： 本文提供了可用作测量，检测和/或筛选过氧亚硝酸盐的试剂的改进的荧光化合物和探针。 本发明的荧光化合物可以产生荧光颜色，例如绿色，黄色，红色或远红色。 本文还提供了用于在活细胞线粒体中选择性染色过氧亚硝酸盐的荧光化合物。 本文还提供了可用于直接或间接测量化学样品和生物样品（例如活生物体中的细胞和组织）中过氧亚硝酸盐的存在和/或量的方法。 还提供了用于检测或筛选过氧亚硝酸盐或可以增加或降低化学和生物样品中过氧亚硝酸盐水平的化合物的高通量筛选方法。

    ANTIFUNGAL COMPOUND AND USES THEREOF
    7.
    发明申请
    ANTIFUNGAL COMPOUND AND USES THEREOF 审中-公开
    抗真菌化合物及其用途

    公开(公告)号：WO2014086285A1

    公开(公告)日：2014-06-12

    申请号：PCT/CN2013/088483

    申请日：2013-12-04

    申请人： THE UNIVERSITY OF HONG KONG

    发明人： SENEVIRATNE, Chaminda Jayampath ,  KAO, Yi Tsun Richard ,  SAMARANAYAKE, Lakshman Perera ,  YUEN, Kwok Yung ,  YANG, Dan ,  WANG, Yu ,  WONG, Sze Wah, Sarah

    IPC分类号： C07D309/34 ,  A61K31/351 ,  A61P31/10 ,  A61P31/18

    CPC分类号： A61K31/351 ,  A01N43/40 ,  A01N59/00 ,  A61K9/0019 ,  A61K9/08 ,  A01N25/34

    摘要： Disclosed herein is a novel antifungal compound, derivatives that are used b treat fungal infections. In a specific embodiment, the compound is a small molecule. In a specific embodiment, the compound described herein inhibits yeast to hypha transition under robust hyphal inducing conditions at lower concentration of the molecule. Also disclosed is a composition comprising the antifungal compound. In a specific embodiment, the composition is a pharmaceutical composition Also disclosed is a method of treating and/or preventing fungal infection using the disclosed compound. The disclosed compound exhibits antifungal activity against wide range of fungal species at slightly higher concentrations. Antifungal compound disclose d herein is use d as anti-biofilm agent against fungal infections. In a specific embodiment, the disclosed compound is effective for systemic fungal infections. In a certain embodiment, the disclosed compound is a broad-spectrum antifungal agent for treating topical local and/or systemic fungal infections. In a specific embodiment, the disclosed compound is used in the prevention or treatment of mycotic infections caused by various fungal pathogens.

    摘要翻译： 本文公开了一种新型抗真菌化合物，其用于治疗真菌感染的衍生物。 在一个具体实施方案中，化合物是小分子。 在一个具体的实施方案中，本文所述的化合物在分子浓度较低的条件下，在稳定的菌丝诱导条件下抑制酵母进行菌丝体转化。 还公开了包含抗真菌化合物的组合物。 在具体实施方案中，组合物是药物组合物。还公开了使用所公开的化合物治疗和/或预防真菌感染的方法。 所公开的化合物在稍高的浓度下对广泛的真菌种类显示出抗真菌活性。 本文中公开的抗真菌化合物d是使用d作为抗真菌感染的抗生物膜剂。 在一个具体实施方案中，所公开的化合物对全身真菌感染是有效的。 在某个实施方案中，所公开的化合物是用于治疗局部局部和/或系统性真菌感染的广谱抗真菌剂。 在具体实施方案中，所公开的化合物用于预防或治疗由各种真菌病原体引起的霉菌感染。

    METHOD FOR SYNTHESIZING 5ß, 6ß-EPOXIDES OF STEROIDS BY A HIGHLY ß-SELECTIVE EPOXIDATION OF Δ5-UNSATURATED STEROIDS CATALYZED BY KETONES
    8.
    发明申请
    METHOD FOR SYNTHESIZING 5ß, 6ß-EPOXIDES OF STEROIDS BY A HIGHLY ß-SELECTIVE EPOXIDATION OF Δ5-UNSATURATED STEROIDS CATALYZED BY KETONES 审中-公开
    通过KETONES催化的DELTA5-不饱和的STEROIDS的高选择性环氧化合成Steroids的5β，6-环氧化物的方法

    公开(公告)号：WO2003074545A1

    公开(公告)日：2003-09-12

    申请号：PCT/CN2003/000140

    申请日：2003-02-24

    申请人： THE UNIVERSITY OF HONG KONG

    发明人： YANG, Dan ,  JIAO, Guansheng

    IPC分类号： C07J21/00

    CPC分类号： C07J71/00

    摘要： A general, efficient, and environmentally friendly method is provided for producing mostly ß-epoxides of Δ 5 -unsaturated steroids using certain ketones as the catalyst along with an oxidizing agent, or by using certain dioxiranes. In another aspect of the invention, a method is provided for producing mostly 5ß, 6ß-epoxides of steroids from Δ 5 -unsaturated steroids having a substituent at the 3α-position by an epoxidation reaction using a ketone along with an oxidizing agent under conditions effective to generate epoxides, or using a dioxirane under conditions effective to generate epoxides. A whole range of Δ 5 -unsaturated steroids, bearing different functional groups such as hydroxy, carbonyl, acetyl of ketal group as well as different side chains, were conveniently converted to the corresponding synthetically and biologically interesting 5ß, 6ß-epoxides with excellent ß-selectivities and high yields.

    摘要翻译： 提供一般的，有效的和环境友好的方法来生产大部分DELTA5-不饱和类固醇的β-环​​氧化物，其中使用某些酮作为催化剂以及氧化剂，或通过使用某些二恶烷。 在本发明的另一方面，提供了一种用于通过环氧化反应使用酮与氧化剂在3α-位上具有取代基的DELTA5-不饱和类固醇生成大部分5β，6β-环氧化物的方法， 产生环氧化物，或在有效产生环氧化物的条件下使用二氧杂环烷。 具有不同官能团（如羟基，羰基，缩酮乙酰基以及不同侧链）的全部范围的DELTA5-不饱和类固醇可方便地转化为具有优异ß选择性的相应的合成和生物学上有趣的5β，6β-环氧化物 产量高。

    REAGENTS FOR HIGHLY SPECIFIC DETECTION OF PEROXYNITRITE
    9.
    发明申请
    REAGENTS FOR HIGHLY SPECIFIC DETECTION OF PEROXYNITRITE 审中-公开
    用于高度检测过氧化物的试剂

    公开(公告)号：WO2007041923A1

    公开(公告)日：2007-04-19

    申请号：PCT/CN2006/002177

    申请日：2006-08-25

    申请人： THE UNIVERSITY OF HONG KONG

    发明人： YANG, Dan ,  WANG, Huali ,  SUN, Zhenning ,  SHEN, Jiangang

    IPC分类号： C07D493/10 ,  C07D403/06 ,  C07F5/02 ,  C07C49/213 ,  G01N31/22

    CPC分类号： C07D207/34 ,  C07D493/10 ,  Y10T436/17

    摘要： This invention provides compositions which specifically reacts with peroxynitrite rather than other reactive oxygen species and reactive nitrogen species. This invention also provides related agents for measuring peroxynitrite. This invention also provides related methods for measuring peroxynitrite in a sample, high-throughput screening fluorescent methods for detecting peroxynitrite and high-throughput methods for screening compounds that increase or decrease the production of peroxynitrite comprising using such compositions and agents.

    摘要翻译： 本发明提供了与过氧亚硝酸盐而不是其它活性氧和活性氮物质特异性反应的组合物。 本发明还提供了用于测量过氧亚硝酸盐的相关试剂。 本发明还提供了用于测量样品中过氧亚硝酸盐的相关方法，用于检测过氧亚硝酸盐的高通量筛选荧光方法和用于筛选增加或减少包含使用这些组合物和试剂的过氧亚硝酸盐生产的化合物的高通量方法。