公开(公告)号：WO2012104585A3

公开(公告)日：2012-12-27

申请号：PCT/GB2012000100

申请日：2012-01-31

Applicant: IMP INNOVATIONS LTD ,  TAYLOR-ROBINSON SIMON D

Inventor： TAYLOR-ROBINSON SIMON D

IPC: G01N33/50 ,  G01N33/574 ,  G01N33/68

CPC classification number: G01N33/5308 ,  G01N33/50 ,  G01N33/57438 ,  G01N33/6812 ,  G01N2800/085 ,  Y10T436/17 ,  Y10T436/174614 ,  Y10T436/201666

Abstract: Disclosed herein is a method for diagnosing hepatic cancer by analysing a sample and determining the level of at least one compound selected from the group consisting of glycine, trimethylamine-N-oxide, hippurate and citrate and comparing the levels in the sample with control levels. The analysis of the sample can involve the determination of a profile for the sample. The methods disclosed are useful in distinguishing between a patient having hepatic cancer and a patient having cirrhosis.

Abstract translation: 本文公开了通过分析样品并确定选自甘氨酸，三甲胺-N-氧化物，马尿酸盐和柠檬酸盐中的至少一种化合物的水平并将样品中的水平与对照水平进行比较来诊断肝癌的方法。 样品的分析可能涉及确定样品的分布。 所公开的方法可用于区分患有肝癌的患者和患有肝硬化的患者。

公开(公告)号：WO2011108981A1

公开(公告)日：2011-09-09

申请号：PCT/SE2011/050232

申请日：2011-03-01

Applicant: PROVTAGAREN AB ,  SKARPING, Gunnar ,  DALENE, Marianne

Inventor： SKARPING, Gunnar ,  DALENE, Marianne

IPC: G05D7/06 ,  G01F15/02 ,  G01N1/22

CPC classification number: G01F1/72 ,  G01F1/68 ,  G01F15/046 ,  G01N1/405 ,  G01N30/7206 ,  G01N35/00693 ,  G01N2030/126 ,  Y10T436/17

Abstract: A flow regulating system for maintaining a stable air flow comprising at least one pump, a mass flow sensor, an ambient temperature sensor, an ambient pressure sensor, a temperature compensation sensor measuring the temperature of said mass flow sensor, and a control system is disclosed, as well as a method for measuring a flow using said flow regulating system, a device for the monitoring of air-borne compounds present in air in both a gas phase and a particle phase, wherein it comprises a sampling device, an enrichment trap 1, a calibration and tuning module, a blank module, said flow regulating system, a chromatography unit, and a detection unit, and a method for the detection of air-born compounds in an air flow by using said monitoring device.

Abstract translation: 公开了一种用于维持稳定气流的流量调节系统，其包括至少一个泵，质量流量传感器，环境温度传感器，环境压力传感器，测量所述质量流量传感器的温度的温度补偿传感器和控制系统 以及用于使用所述流量调节系统测量流量的方法，用于监测存在于气相和颗粒相中的空气中的空气传播化合物的装置，其中它包括取样装置，富集阱1 ，校准和调谐模块，空白模块，所述流量调节系统，色谱单元和检测单元，以及通过使用所述监测装置来检测空气流中的气相化合物的方法。

公开(公告)号：WO2011033531A1

公开(公告)日：2011-03-24

申请号：PCT/IN2010/000623

申请日：2010-09-15

Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH ,  AYYAPANPILLAI, Ajayaghosh ,  SIVARAMAPANICKER, Sreejith ,  KIZHUMURI, P. Divya ,  PUROSHOTHAMAN, Jayamurthy

Inventor： AYYAPANPILLAI, Ajayaghosh ,  SIVARAMAPANICKER, Sreejith ,  KIZHUMURI, P. Divya ,  PUROSHOTHAMAN, Jayamurthy

IPC: C07D401/14 ,  C07D409/14 ,  A61K31/444

CPC classification number: C07D409/14 ,  C07D401/14 ,  G01N2021/7786 ,  Y10T436/17 ,  Y10T436/172307

Abstract: The present invention describes the development of a end-capped bipyridine compound having formula (A) and the zinc complex having formula (B). The, assay having formula (1) can be used to estimate and quantify the amount of zinc ions by monitoring the fluorescence changes. The assay with formula (1) can be use to image and detect Zn 2 ions in MCF7 cell lines. The zinc complex of formula (2) and (4) can be used as a fluorescent sensor for cyanide anions using analyte replacement protocol. The assay with formula (2) is, selective only to cyanide anions even in the presence of other competing anions. The assay with formula (3) having bright green solid state emission is used for the preparation of formula (4). The orange fluorescent powder of assay with formula (4) is used for the selective detection of CN ions in aqueous solution.

Abstract translation: 本发明描述了具有式（A）的封端的联吡啶化合物和具有式（B）的锌络合物的开发。 具有式（1）的测定可用于通过监测荧光变化来估计和量化锌离子的量。 式（1）的测定可用于对MCF7细胞系中的Zn2离子进行成像和检测。 式（2）和（4）的锌络合物可用作使用分析物置换方案的氰化物阴离子的荧光传感器。 具有式（2）的测定是，即使在存在其它竞争性阴离子的情况下也仅对氰化物阴离子有选择性。 使用具有明亮的绿色固体发射的式（3）的测定用于制备式（4）。 用式（4）测定的橙色荧光粉用于水溶液中CN离子的选择性检测。

公开(公告)号：WO2011017317A1

公开(公告)日：2011-02-10

申请号：PCT/US2010/044240

申请日：2010-08-03

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  MENON, Vinod, P.

Inventor： MENON, Vinod, P.

IPC: G01N33/52

CPC classification number: G01N33/523 ,  G01N33/526 ,  G01N2800/26 ,  Y10T436/17 ,  Y10T436/173076 ,  Y10T436/177692 ,  Y10T436/179228 ,  Y10T436/25 ,  Y10T436/255

Abstract: The present disclosure provides methods and kits to detect and quantitate NOx compounds in a biological sample. The methods include reacting a mixture comprising a nitrite compound a chromogenic reagent to form a colored compound, contacting the mixture with a retention medium configured to retain the colored compound, and detecting the colored compound retained on the retention medium.

Abstract translation: 本公开提供了用于检测和定量生物样品中的NOx化合物的方法和试剂盒。 所述方法包括使包含亚硝酸盐化合物的显色试剂的混合物反应以形成有色化合物，使该混合物与构造成保留着色化合物的保留介质接触，并检测保留在保留介质上的着色化合物。

公开(公告)号：WO2010105193A1

公开(公告)日：2010-09-16

申请号：PCT/US2010/027189

申请日：2010-03-12

Applicant: ARETE THERAPEUTICS, INC. ,  GLESS, Richard, D. ,  COSFORD, Rebecca ,  DEAN, Tad ,  HORTON, Michael ,  MARBURY, Dean ,  MONTGOMERY, Malcolm

Inventor： GLESS, Richard, D. ,  COSFORD, Rebecca ,  DEAN, Tad ,  HORTON, Michael ,  MARBURY, Dean ,  MONTGOMERY, Malcolm

IPC: G01N30/88

CPC classification number: G01N30/88 ,  G01N2030/884 ,  Y10T436/17

Abstract: Disclosed herein are methods for quantitative determination of acetamide in a composition of a sample. The method comprises the addition of deuterium - labelled acetamide-d3, extraction by chromatography and detection by mass spectrometry.

Abstract translation: 本文公开了在样品组合物中定量测定乙酰胺的方法。 该方法包括加入氘标记的乙酰胺-d3，通过色谱提取和质谱检测。

公开(公告)号：WO2009139864A3

公开(公告)日：2010-03-04

申请号：PCT/US2009002958

申请日：2009-05-13

Applicant: UNIV CALIFORNIA ,  BRASLAU REBECCA

Inventor： BRASLAU REBECCA

IPC: G01N33/28 ,  G01N21/64

CPC classification number: G01N33/50 ,  A61K31/69 ,  A61K49/0006 ,  A61K49/0019 ,  A61K49/0021 ,  G01N33/52 ,  Y10S435/81 ,  Y10T436/142222 ,  Y10T436/145555 ,  Y10T436/17 ,  Y10T436/173845 ,  Y10T436/177692 ,  Y10T436/203332

Abstract: The invention herein disclosed provides for compositions, methods for synthesizing said compositions, and methods for using said compositions, wherein the compositions and methods may be used to bind to and/or deactivate a poison oak oil, such as urushiol. The compositions and methods can be used to treat and/or reduce an inflammatory reaction and/or hypersensitivity to natural compounds found in poison oak, poison ivy, poison sumac, mango, lac tree, and cashew nut.

Abstract translation: 本文公开的本发明提供组合物，用于合成所述组合物的方法和使用所述组合物的方法，其中所述组合物和方法可用于结合和/或钝化毒性橡木油，例如漆酚。 组合物和方法可以用于治疗和/或减少在毒栎，毒藤，毒蛇科，芒果，漆树和腰果中发现的天然化合物的炎症反应和/或超敏反应。

公开(公告)号：WO2009142742A1

公开(公告)日：2009-11-26

申请号：PCT/US2009/003146

申请日：2009-05-20

Applicant: CANTIMER, INC. ,  STEWART, Ray, F. ,  DICKERMAN-STEWART, Aaron

Inventor： STEWART, Ray, F. ,  DICKERMAN-STEWART, Aaron

IPC: G01N33/545 ,  B01D15/36 ,  B01J47/00 ,  G01N30/00 ,  G01N1/00

CPC classification number: G01N33/545 ,  B01J39/04 ,  B01J45/00 ,  G01N1/4044 ,  Y10T436/144444 ,  Y10T436/147777 ,  Y10T436/17 ,  Y10T436/171538 ,  Y10T436/201666

Abstract: Devices, methods and systems effective to evaluate a physical or chemical property of an ion exchange resin-treated biological fluid sample are provided.

Abstract translation: 提供了有效评估离子交换树脂处理的生物流体样品的物理或化学性质的装置，方法和系统。

公开(公告)号：WO2009045759A1

公开(公告)日：2009-04-09

申请号：PCT/US2008/077060

申请日：2008-09-19

Applicant: SABIC INNOVATIVE PLASTICS IP BV ,  BRACK, Hans-Peter ,  CAMPMAN, Maarten, Antoon, Jan ,  OYEVAAR, Martin Herke ,  PEREZ DE DIEGO, Yohana ,  VAN DER WEKKE, Laurus ,  WILLEMSE, Dennis James Patrick Maria

Inventor： BRACK, Hans-Peter ,  CAMPMAN, Maarten, Antoon, Jan ,  OYEVAAR, Martin Herke ,  PEREZ DE DIEGO, Yohana ,  VAN DER WEKKE, Laurus ,  WILLEMSE, Dennis James Patrick Maria

IPC: C08G64/30

CPC classification number: C08G64/307 ,  C08G64/30 ,  Y10T436/144444 ,  Y10T436/17 ,  Y10T436/173845

Abstract: A non-reactive monomer mixture is formed from a dihydroxy component having one or more dihydroxy compounds dissolved in a melted diaryl carbonate. The dihydroxy component has one or more dihydroxy compounds with a melting point above the melting point of the diaryl carbonate. The dihydroxy component has less than 600 ppb alkali metal, an acid stabilizer, or both less than 600 ppb alkali metal and an acid stabilizer. The dihydroxy compounds of the dihydroxy component and the diaryl carbonate are present in a mole ratio of from 0.9 to 1.1. The monomer mixture is at a temperature between the saturation point of the monomer mixture and the highest melting temperature of the individual dihydroxy compounds. The non-reactive monomer mixture can be stored and transported and then polymerized to form polycarbonate upon addition of a catalyst.

Abstract translation: 非反应性单体混合物由具有溶解在熔融的碳酸二芳基酯中的一种或多种二羟基化合物的二羟基组分形成。 二羟基组分具有一种或多种熔点高于碳酸二芳基酯的熔点的二羟基化合物。 二羟基组分具有少于600ppb的碱金属，酸稳定剂，或两者少于600ppb的碱金属和酸稳定剂。 二羟基成分和碳酸二芳基酯的二羟基化合物的摩尔比为0.9-1.1。 单体混合物处于单体混合物的饱和点和各个二羟基化合物的最高熔融温度之间的温度。 非反应性单体混合物可以储存和运输，然后在加入催化剂时聚合形成聚碳酸酯。

公开(公告)号：WO2009042932A1

公开(公告)日：2009-04-02

申请号：PCT/US2008/077971

申请日：2008-09-26

Applicant: CALDERA PHARMACEUTICALS, INC. ,  BIRNBAUM, Eva, R. ,  WARNER, Benjamin, P. ,  BALDWIN, Sharon, M. ,  BERGER, Jennifer, A. ,  PETERSON-COURT, Lori, J. ,  HARRIS, Michael, N. ,  MILLER, Rebecca, L.E.

Inventor： BIRNBAUM, Eva, R. ,  WARNER, Benjamin, P. ,  BALDWIN, Sharon, M. ,  BERGER, Jennifer, A. ,  PETERSON-COURT, Lori, J. ,  HARRIS, Michael, N. ,  MILLER, Rebecca, L.E.

IPC: G01N23/223

CPC classification number: C12Q1/485 ,  C12Q1/37 ,  G01N21/75 ,  G01N23/223 ,  G01N33/20 ,  G01N33/6842 ,  G01N2223/076 ,  G01N2333/91215 ,  G01N2333/96441 ,  Y10T436/17 ,  Y10T436/200833

Abstract: The present invention includes a method for analyzing reactions. The method includes the steps of providing a solution of at least one acceptor chemical and at least one donor chemical. The donor chemical is capable of donating a chemical moiety to the acceptor chemical. The solution further includes at least one controller chemical that affects the reaction between the donor chemical and the acceptor chemical. The solution is then incubated so that a portion of the acceptor chemical reacts with the donor chemical to form an acceptor product. Unreacted donor chemical is separated from the acceptor product. The acceptor product or the donor chemical is then measured using X-ray fluorescence. Further methods of analysis are disclosed.

Abstract translation: 本发明包括分析反应的方法。 该方法包括提供至少一种受体化学品和至少一种供体化学品的溶液的步骤。 供体化学品能够向受体化学品提供化学部分。 该溶液还包括影响供体化学品和受体化学物质之间的反应的至少一种控制剂化学品。 然后将溶液温育使得一部分受体化合物与供体化学品反应形成受体产物。 未反应的供体化学品与受体产物分离。 然后使用X射线荧光测量受体产物或供体化学物质。 公开了进一步的分析方法。

公开(公告)号：WO2009007676A2

公开(公告)日：2009-01-15

申请号：PCT/GB2008/002222

申请日：2008-06-27

Applicant: Cambridge Enterprise Limited ,  LOWE, Christopher Robin ,  HUSSAIN, Abid ,  MIMMACK, Michael Luis ,  HAIGH, Jonathan Michael

Inventor： LOWE, Christopher Robin ,  HUSSAIN, Abid ,  MIMMACK, Michael Luis ,  HAIGH, Jonathan Michael

IPC: C07C309/15 ,  C07D277/56 ,  C07D417/12 ,  G01N33/543 ,  C07C309/51

CPC classification number: C07C309/51 ,  B01D15/3804 ,  B01J20/286 ,  B01J20/289 ,  B01J20/3244 ,  B01J2220/54 ,  C07K1/22 ,  C40B30/04 ,  C40B40/04 ,  C40B50/14 ,  G01N33/531 ,  G01N33/532 ,  G01N33/54353 ,  Y10T436/143333 ,  Y10T436/145555 ,  Y10T436/147777 ,  Y10T436/17 ,  Y10T436/200833

Abstract: The invention provides biomolecule binding ligands, collections of biomolecule binding ligands, and their use in the purification of biological mixtures and in the identification of ligands having an affinity for a substance. The ligand is a compound of formula (III) or a compound of formula (IV): wherein for compounds of formula (I) one of R 1a , R 1b ,R 2 , R 3 and R 4 is a group comprising a linker attached to a support, and the others of R 1a , R 1b , R 2 , R 3 and R 4 are independently selected from optionally substituted C 1-20 alkyl, optionally substituted C 3-20 heterocyclyl or optionally substituted C 5-20 aryl, and R 1a , R 1b and R 2 are additionally selected from hydrogen, and R 2 is additionally further selected from -S(=O)R 5 and -C(=S)NR 6 R 7 , wherein R 5 , R 6 and R 7 are independently optionally substituted C 1-20 alkyl, optionally substituted C 3-20 heterocyclyl or optionally substituted C 5-20 aryl, or, optionally, two or more of the others of R 1a , R 1b , R 2 , R 3 and R 4 , together with the atoms to which they are bound, may form a ring; and for compounds of formula (II) one of R 1a , R 1b , R 3 and R 4 isa group comprising a linker attached to a support, and the others of R 1a , R 1b , R 3 and R 4 are independently selected optionally substituted C 1-20 alkyl, optionally substituted C 3-20 heterocyclyl or optionally substituted C 5-20 aryl, and R 1a , and R 1b are additionally selected from hydrogen, or, optionally, two or more of the others of R 1a , R 1b , R 3 and R 4 , together with the atomsto which they are bound, may form a ring.

Abstract translation: 本发明提供了生物分子结合配体，生物分子结合配体的集合，以及它们在纯化生物混合物中的用途以及鉴定对物质具有亲和力的配体。 配体是式（III）化合物或式（Ⅳ）化合物：其中对于式（I）化合物，R 1a，R 1b，R 2，R 3和R 4中的一个是包含连接于载体上的连接基团， 其中R1a，R1b，R2，R3和R4独立地选自任选取代的C 1-20烷基，任选取代的C 3-20杂环基或任选取代的C 5-20芳基，并且R 1a，R 1b和R 2另外选自氢，并且R 2是 另外还选自-S（= O）R 5和-C（= S）NR 6 R 7，其中R 5，R 6和R 7独立地是任选取代的C 1-20烷基，任选取代的C 3-20杂环基或任选取代的C 5-20芳基，或 任选地，R 1a，R 1b，R 2，R 3和R 4中的两个或更多个与它们所结合的原子一起形成环; 并且对于式（II）化合物，R 1a，R 1b，R 3和R 4中的一个是包含连接于载体的连接体的基团，R 1a，R 1b，R 3和R 4中的其它基团独立地选自任选被取代的C 1-20烷基， C 3-20杂环基或任选取代的C 5-20芳基，并且R 1a和R 1b另外选自氢，或任选地，R 1a，R 1b，R 3和R 4中的两个或多个，以及它们所结合的原子团 ，可能会形成一个戒指。