公开(公告)号：WO2009068994A3

公开(公告)日：2009-06-04

申请号：PCT/IB2008/003667

申请日：2008-11-26

Applicant: ULTRATHERA TECHNOLOGIES, INC. ,  MAHER, Kevin

Inventor： MAHER, Kevin

IPC: A61B5/00

Abstract: Vestibular stimulation systems, control systems, doses, and methods of use are provided. Generally, the vestibular stimulation system disclosed includes a restraint system (e.g. a chair) that holds a subject in a position relative to the system. The subject can then be rotated around one, two or three rotational axes individually or simultaneously in a controlled manner. A computer system controls the vestibular system function and collects and stores data. Specific amounts or doses of stimuli can be administered. Physiological responses to various types of vestibular stimulation can then be tested and recorded.

公开(公告)号：WO2003013703A1

公开(公告)日：2003-02-20

申请号：PCT/US2002/024663

申请日：2002-08-02

Applicant: ACLARA BIOSCIENCES, INC. ,  KAO, Hung, Pin ,  MAHER, Kevin

Inventor： KAO, Hung, Pin ,  MAHER, Kevin

IPC: B01D57/02

CPC classification number: G01N27/44791 ,  B01D57/02 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502746 ,  B01L3/563 ,  B01L2200/0636 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2400/0415 ,  B01L2400/084 ,  G01N27/44721 ,  G01N27/44782

Abstract: A microfabricated device, manifold system and method for electrokinetically moving biological and chemical samples including a multiplexed detection chamber for receiving a plurality of adjacent sample streams to be detected. The device includes a plurality of adjacent input channels connected to the detection chamber via an enlarged section having an expanding taper at its widest end or other shapes so that adjacent sample streams enter the detection chamber and remain discrete for a threshold distance to the detection chamber to minimize lateral diffusion.

Abstract translation: 用于电动移动生物和化学样品的微加装置，歧管系统和方法，包括用于接收待检测的多个相邻样品流的多路复用检测室。 该装置包括多个相邻的输入通道，该多个相邻的输入通道经由扩大部分连接到检测室，该扩大部分在其最宽端或其他形状具有扩张锥形，使得相邻的样品流进入检测室并保持离散以到达检测室的阈值距离 最小化横向扩散。

公开(公告)号：WO2003006964A1

公开(公告)日：2003-01-23

申请号：PCT/US2002/019494

申请日：2002-06-19

Applicant: ACLARA BIOSCIENCES, INC. ,  BJORNSON, Torleif O. ,  MAHER, Kevin ,  GLUSZCZAK, Michael, Robert

Inventor： BJORNSON, Torleif O. ,  MAHER, Kevin ,  GLUSZCZAK, Michael, Robert

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0816 ,  G01N21/05 ,  G01N21/645 ,  G01N21/8507 ,  G01N27/44721 ,  G01N27/44791 ,  G01N2021/0346 ,  G01N2021/058 ,  G01N2021/6439 ,  G01N2021/6467 ,  G01N2021/6482

Abstract: A system for material excitation in microfluidic devices is described. Aspects of the invention resemble a submerged periscope when in use. A reflecting surface (20) may be provided in connection with a simple support (18). The reflecting surface (20) is used to direct a laser beam (22) along one or more microfluidic trenches or channels (6). Alternately, a reflecting surface (20) may be provided on a prism. Directing a beam (22) along multiple paths is preferably accomplished by scanning a single laser across or around the reflecting surface (20) provided. Provision may be made for at least a portion of the support (18) to be used as an electrode to assist in electrokinetically driving fluids and/or ions within the mocrofluidic device.

Abstract translation: 描述了微流体装置中材料激发的系统。 本发明的方面在使用时类似于浸没潜望镜。 反射表面（20）可以与简单支撑件（18）相关联地设置。 反射表面（20）用于沿着一个或多个微流体沟槽或通道（6）引导激光束（22）。 或者，反射表面（20）可以设置在棱镜上。 优选地通过沿着所提供的反射表面（20）或其周围扫描单个激光器来实现沿着多个路径引导光束（22）。 可以提供用于支撑件（18）的至少一部分用作电极以辅助电动驱动流体装置内的流体和/或离子。

公开(公告)号：WO2022266371A1

公开(公告)日：2022-12-22

申请号：PCT/US2022/033864

申请日：2022-06-16

Applicant: GEORGIA TECH RESEARCH CORPORATION ,  CHILDREN’S HEALTHCARE OF ATLANTA, INC. ,  EMORY UNIVERSITY ,  DASI, Lakshmi Prasad ,  HATOUM, Hoda ,  MAHER, Kevin ,  SAMAEE, Milad ,  SHASHIDHARAN, Subhadra

Inventor： DASI, Lakshmi Prasad ,  HATOUM, Hoda ,  MAHER, Kevin ,  SAMAEE, Milad ,  SHASHIDHARAN, Subhadra

IPC: A61B17/122 ,  A61B2/06

Abstract: A passive implantable medical device for controlling a flow of fluid through a tube within a patient includes a first component and a second component movably coupled to one another and defining a central passage configured for receiving a portion of the tube therethrough. The passive implantable medical device is configured for moving between a first configuration and a second configuration to constrict a portion of the tube. An active implantable medical device for controlling a flow of a first fluid through a tubing includes a flow control cuff comprising a stiff outer wall and a deformable inner wall which defines a central opening sized such that the tubing can extend therethrough. A pump is configured to modulate a pressure of the second fluid within the interior space to apply a constrictive force to a section of the tubing.

公开(公告)号：WO2003052821A1

公开(公告)日：2003-06-26

申请号：PCT/US2002/041651

申请日：2002-12-06

Applicant: ACLARA BIOSICENCES, INC. ,  BJORNSON, Torleif ,  MAHER, Kevin

Inventor： BJORNSON, Torleif ,  MAHER, Kevin

IPC: H01L23/48

CPC classification number: B01L9/527 ,  B01J2219/00783 ,  B01J2219/00804 ,  B01J2219/0081 ,  B01J2219/0095 ,  B01L2200/02 ,  B01L2200/025 ,  B01L2300/0816 ,  B01L2400/0415 ,  G01N27/44704 ,  G01N27/44782 ,  G01N27/44791 ,  H01L2924/0002 ,  H05K3/222 ,  H01L2924/00

Abstract: A microfluidic analytical apparatus (10) comprising a microfluidic card pairing (12) with a corresponding circuit card (14) and the circuit card pairing (12) with corresponding conductive fingers (16). The microfluidic card (12) has a plurality of channels (32) and ports (54) on a top surface of the card in a desired configuration, the ports (54) in fluid communication with the channels (32). The circuit card (14) has a plurality of conductive pins (60) projecting from a bottom surface of the card and having a configuration that corresponds to the particular configuration of the ports (54) of the microfluidic card (12) that it is paired with. The circuit card (14) is received within a holder (20) that provides that provides multiple functions. Conductive pads (18) are disposed on a top surface of the circuit card (14), the pads (18) in electrical communication with the conductive pins (60) and corresponding to a configuration of conductive fingers (16) connected to a power source to provide voltage to the microfluidic card (12) for analytical operations. Additionally, detection difficulties associates with non-uniformities present on the card surface are overcome using a detection system incorporating a compliantly mounted microscopic head.

Abstract translation: 一种微流体分析装置（10），包括具有对应的电路卡（14）的微流控卡配对（12）和具有对应导电指状物（16）的电路卡配对（12）。 微流控卡（12）具有在卡的顶表面上具有所需配置的多个通道（32）和端口（54），所述端口（54）与通道（32）流体连通。 电路卡（14）具有从卡的底表面突出的多个导电引脚（60），并且具有与其配对的微流控卡（12）的端口（54）的特定配置相对应的配置 用。 电路卡（14）被接收在提供多个功能的保持器（20）内。 导电焊盘（18）设置在电路卡（14）的顶表面上，焊盘（18）与导电引脚（60）电连通并对应于连接到电源的导电指状物（16）的结构 以向微流控卡（12）提供电压用于分析操作。 此外，使用包含柔性安装的微观头的检测系统来克服与卡表面上存在的非均匀性相关联的检测困难。