公开(公告)号：WO2012010871A3

公开(公告)日：2012-03-15

申请号：PCT/GB2011051335

申请日：2011-07-15

Applicant: UNIV EXETER ,  SHAW ANDREW MARK

Inventor： SHAW ANDREW MARK

IPC: G06F19/00

CPC classification number: G01N33/54373 ,  G01N33/564 ,  G01N2333/4716 ,  G01N2333/4724 ,  G01N2800/52 ,  G06F19/18 ,  G06F19/34 ,  G16H50/50

Abstract: We describe a system/method for predicting the outcome of a medical procedure on a patient. The system/method uses using complement cascade data representing levels of a set of complement cascade markers in the patient at a succession of peri-operative time intervals, determining deviations from a model of the response to provide a pre-symptomatic prediction of the outcome. In embodiments the complement cascade pathways include the lytic pathway and at least one of the lectin pathway, the classical pathway and the alternative pathway, and the biomarkers include at least C3. The system may include an electroluminescence or plasmon-resonance multianalyte detector to analyse a blood sample from the patient.

Abstract translation: 我们描述一种用于预测患者的医疗程序结果的系统/方法。 系统/方法使用补体级联数据来表示患者中连续的围手术期间隔的一组补体级联标记的水平，确定与反应模型的偏差以提供结果的预先症状预测。 在实施方案中，补体级联途径包括溶解途径和凝集素途径，经典途径和替代途径中的至少一种，生物标志物至少包括C3。 该系统可以包括电致发光或等离子体共振多分析仪检测器以分析来自患者的血液样品。

公开(公告)号：WO2008117087A3

公开(公告)日：2008-11-13

申请号：PCT/GB2008050202

申请日：2008-03-19

Applicant: UNIV EXETER ,  SHAW ANDREW MARK ,  OLKHOV ROUSLAN VLADIMIR ,  BARNES WILLIAM LESLIE

Inventor： SHAW ANDREW MARK ,  OLKHOV ROUSLAN VLADIMIR ,  BARNES WILLIAM LESLIE

IPC: G01N21/21 ,  G01N21/55 ,  G01N33/551 ,  G01N33/553

CPC classification number: G01N21/554 ,  B82Y15/00 ,  B82Y30/00 ,  G01N21/211 ,  G01N21/253 ,  G01N33/54313 ,  G01N33/54373 ,  G01N33/553 ,  Y10T436/25

Abstract: This invention relates to photonic biosensor arrays in particular employing plasmon resonance based sensing, and to methods and apparatus for reading such arrays. A biosensor array for plasmon resonance-based sensing of a plurality of different biological targets simultaneously, the array comprising a transparent substrate having a surface bearing a plurality of assay spots for plasmon resonance sensing, each of said assay spots comprising a discrete metallic island, a said metallic island comprising a plurality of metallic nanoparticles to which are attached functionalising molecules for binding to a said biological target, different said islands bearing different said functionalising molecules for binding to different ones of said biological targets, and wherein total internal reflection of light at said surface at a wavelength at or near a said plasmon resonance results in scattering of said light away from said surface, said scattering being modulated by said binding of said biological targets.

Abstract translation: 本发明涉及特别采用基于等离子体共振的感测的光子生物传感器阵列，并且涉及用于读取这种阵列的方法和装置。 1.一种用于同时基于等离子体共振的多个不同生物靶标感测的生物传感器阵列，所述阵列包含透明基底，所述透明基底具有承载用于等离子体共振感测的多个化验点的表面，所述化验点中的每一个均包含离散金属岛， 所述金属岛包含多个金属纳米颗粒，所述金属纳米颗粒附着有官能化分子以结合到所述生物靶上，不同的所述岛带有不同的所述功能化分子以结合不同的所述生物靶，并且其中所述光的全内反射 在所述等离子体激元共振处或附近的波长处的表面导致所述光从所述表面散射，所述散射通过所述生物靶的所述结合来调节。

公开(公告)号：WO2005088270A2

公开(公告)日：2005-09-22

申请号：PCT/GB2005050035

申请日：2005-03-15

Applicant: EVANESCO LTD ,  SHAW ANDREW MARK

Inventor： SHAW ANDREW MARK

IPC: G01N21/55 ,  G01N21/00

CPC classification number: G01N21/552 ,  G01N21/7703

Abstract: This invention is generally concerned with apparatus and methods for monitoring fluids, in particular critical fluids such as lubricants, based upon evanescent wave techniques. A sensor module, in particular for use with attenuated total internal (ATIR) reflection apparatus for optically determining the condition of a fluid, the sensor module comprising: an evanescent wave sensor; a module housing for said sensor; and an optical connector for connecting said sensor to said ATIR apparatus. Preferably the sensor comprises a tapered optical fibre with a high reflectivity mirror at one or both ends. Also attenuated total internal reflection (TIR) apparatus for the sensor.

Abstract translation: 本发明一般涉及用于基于ev逝波技术来监测流体，特别是关键流体如润滑剂的装置和方法。 传感器模块，特别是用于衰减的全内部（ATIR）反射设备，用于光学地确定流体的状态，所述传感器模块包括：ev逝波传感器; 用于所述传感器的模块外壳; 以及用于将所述传感器连接到所述ATIR设备的光学连接器。 优选地，传感器包括在一端或两端具有高反射镜的锥形光纤。 也是传感器的衰减全内反射（TIR）装置。

公开(公告)号：WO2006054117A3

公开(公告)日：2006-12-21

申请号：PCT/GB2005050203

申请日：2005-11-16

Applicant: EVANESCO LTD ,  SHAW ANDREW MARK

Inventor： SHAW ANDREW MARK

IPC: G01F23/292

CPC classification number: G01F23/292

Abstract: This invention is generally concerned with methods and apparatus for optical monitoring of fluid level and quality, in particular by means of evanescent wave techniques such as cavity ring-down spectroscopy. We describe a fuel monitoring system, comprising: an evanescent wave fuel sensor for monitoring said fuel, the sensor comprising a light source and a transducer for providing an electrical signal in response to light from said light source, and having a light path between said light source and said transducer including an evanescent wave sensing region; and a processor coupled to said fuel sensor, for converting said electrical signal from said transducer into a signal characterising said monitored fuel; and an output coupled to said processor, for outputting a signal responsive to said fuel characterising signal. We further describe apparatus for jointly determining depth of fluid in a tank and characterising the fluid according to depth, and a fluid storage tank having a three dimensional structure for containing fluid, and a three-dimensional array of fibre-optic sensors integrated into said tank structure.

Abstract translation: 本发明通常涉及用于光学监测液位和质量的方法和设备，特别是借助于衰减波技术，例如空腔衰荡光谱学。 我们描述了一种燃料监测系统，包括：用于监测所述燃料的瞬逝波燃料传感器，所述传感器包括光源和用于响应于来自所述光源的光提供电信号并且在所述光之间具有光路的换能器 源并且所述换能器包括eva逝波感测区域; 以及耦合到所述燃料传感器的处理器，用于将来自所述换能器的所述电信号转换为表征所述被监测燃料的信号; 以及耦合到所述处理器的输出端，用于输出响应于所述燃料表征信号的信号。 我们进一步描述了用于共同确定罐内流体深度并根据深度表征流体的装置以及具有用于容纳流体的三维结构的流体储罐以及集成到所述罐内的光纤传感器的三维阵列 结构体。