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    APOPTOTIC CELL-MEDIATED TRANSFECTION OF MAMMALIAN CELLS WITH INTERFERING RNA
    1.
    发明申请
    APOPTOTIC CELL-MEDIATED TRANSFECTION OF MAMMALIAN CELLS WITH INTERFERING RNA 审中-公开
    凋亡细胞介导的哺乳动物细胞与干扰RNA的转染

    公开(公告)号：WO2008039980A3

    公开(公告)日：2008-12-31

    申请号：PCT/US2007079876

    申请日：2007-09-28

    Applicant: UNIV LOMA LINDA ,  LI FENGCHUN ,  ESCHER ALAN P

    Inventor： LI FENGCHUN ,  ESCHER ALAN P

    IPC: C07H21/02 ,  A01N43/04 ,  A61K31/70 ,  C07H21/04 ,  C12N15/11

    CPC classification number: C12N5/0602 ,  A61K31/7088 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/531

    Abstract: Mammalian host cells for use in a cell-mediated tranfection process, which contain an RNAi molecule and an expression vector for a pro-apoptotic protein. The method includes inducing apoptotic cell (AC) death in mammalian cells that contain an RNAi molecule capable of downregulating a chosen target gene. Living cells expressing the target gene are then exposed to the ACs. The ACs are processed by the living cells, and the RNAi molecule in the ACs downregulates the expression of the target gene in living cells.

    Abstract translation: 用于细胞介导的转染过程的哺乳动物宿主细胞，其含有RNAi分子和促凋亡蛋白的表达载体。 该方法包括在含有能够下调所选靶基因的RNAi分子的哺乳动物细胞中诱导凋亡细胞（AC）死亡。 然后将表达靶基因的活细胞暴露于AC。 AC由活细胞处理，并且AC中的RNAi分子下调活细胞中靶基因的表达。

    SUBSTANCES FOR PREVENTING AND TREATING AUTOIMMUNE DISEASES
    2.
    发明申请
    SUBSTANCES FOR PREVENTING AND TREATING AUTOIMMUNE DISEASES 审中-公开
    预防和治疗自身免疫疾病的物质

    公开(公告)号：WO2004034966A3

    公开(公告)日：2004-07-08

    申请号：PCT/US0324625

    申请日：2003-08-06

    Applicant: UNIV LOMA LINDA ,  ESCHER ALAN P ,  LI FENGCHUN

    Inventor： ESCHER ALAN P ,  LI FENGCHUN

    IPC: A61K38/17 ,  A61K39/00 ,  A61K48/00 ,  C07H21/04 ,  C07K14/075 ,  C07K14/47 ,  C12N5/00 ,  C12N15/00 ,  C12N15/87

    CPC classification number: C07K14/4713 ,  A61K38/1709 ,  A61K39/0008 ,  A61K48/005 ,  A61K2039/53 ,  A61K2039/55516 ,  C07K14/005 ,  C07K14/4747 ,  C12N2710/10322 ,  C12N2840/203

    Abstract: A substance for preventing, delaying the onset of, or treating one or more than one autoimmune disease, the substance comprising a polynucleotide construct comprising a polynucleotide sequence encoding the pro-apoptotic protein BAX and encoding one or more than one autoantigen for the autoimmune disease. A method for preventing, delaying the onset of or treating an autoimmune disease in a patient comprising selecting a patient who is susceptible to developing the autoimmune disease, who is developing the autoimmune disease or who has the autoimmune disease and administering to the patient one or more than one dose of a polynucleotide construct comprising a polynucleotide sequence encoding the pro-apoptotic protein BAX and encoding one or more than one autoantigen for an autoimmune disease, or comprising a polynucleotide sequence encoding the adenoviral protein E3-GP19k, or comprising a polynucleotide sequence encoding DeltaBCL-2.

    Abstract translation: 一种用于预防，延迟一种或多于一种自身免疫性疾病发作或治疗一种或多种自身免疫性疾病的物质，所述物质包含多核苷酸构建体，所述多核苷酸构建体包含编码促凋亡蛋白BAX并编码自身免疫性疾病的一种或多种自身抗原的多核苷酸序列。 一种预防，延迟或治疗患者自身免疫疾病的方法，包括选择易患发展自身免疫性疾病的患者，正在发展自身免疫性疾病或患有自身免疫性疾病的患者，并给患者施用一种或多种 所述多核苷酸构建体包含编码促凋亡蛋白BAX并编码一种或多于一种自身免疫疾病的自身抗原或包含编码腺病毒蛋白E3-GP19k的多核苷酸序列或包含编码多核苷酸序列的多核苷酸序列的多核苷酸构建体 DeltaBCL-2。

    SUBSTANCES, COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING IMMUNE-MEDIATED INFLAMMATORY DISORDERS
    3.
    发明申请
    SUBSTANCES, COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING IMMUNE-MEDIATED INFLAMMATORY DISORDERS 审中-公开
    用于预防和治疗免疫介导的炎症性疾病的物质，组合物和方法

    公开(公告)号：WO2006124375A3

    公开(公告)日：2007-11-22

    申请号：PCT/US2006017763

    申请日：2006-05-05

    Applicant: UNIV LOMA LINDA ,  ESCHER ALAN P ,  LI FENGCHUN

    Inventor： ESCHER ALAN P ,  LI FENGCHUN

    IPC: C12N15/00 ,  A61K31/713 ,  C07H21/04

    CPC classification number: A61K39/0008 ,  A61K2039/53 ,  A61K2039/55516

    Abstract: A substance or a composition for preventing, delaying the onset of or treating one or more than one immune-mediated inflammatory disorder in an organism who is susceptible to developing the immune-mediated inflammatory disorder, who is developing the immune-mediated inflammatory disorder or who has the immune-mediated inflammatory disorder. A method of preventing, delaying the onset of or treating an organism who is susceptible to developing the immune-mediated inflammatory disorder, who is developing the immune-mediated inflammatory disorder or who has the immune-mediated inflammatory disorder.

    Abstract translation: 用于预防，延迟在发展免疫介导的炎症性疾病的易感发展的生物体中发生或治疗一种或多于一种免疫介导的炎症的物质或组合物 具有免疫介导的炎症性疾病。 一种预防，延迟发展或治疗易于发展免疫介导的炎性病症的生物体的发生免疫介导的炎性病症或具有免疫介导的炎性病症的生物体的方法。

    BACTERIAL STRAINS EXPRESSING METHYLASE GENES AND USES THEREOF
    6.
    发明申请
    BACTERIAL STRAINS EXPRESSING METHYLASE GENES AND USES THEREOF 审中-公开
    表达甲基化酶基因的细菌菌株及其用途

    公开(公告)号：WO2013044177A3

    公开(公告)日：2013-07-11

    申请号：PCT/US2012056761

    申请日：2012-09-21

    Applicant: UNIV LOMA LINDA

    Inventor： ESCHER ALAN P

    IPC: A61K39/10

    CPC classification number: A61K39/0241 ,  A61K39/0008 ,  A61K49/00 ,  C12N9/1007 ,  C12N9/22 ,  C12N9/506 ,  C12N15/117 ,  C12N15/70 ,  C12N2310/17

    Abstract: The subject technology relates to compositions and methods to construct strains of E. coli cells carrying a chromosomal copy of a toxic gene under the control of a constitutive promoter. In some non-limiting examples, the toxic gene may be a gene coding for the Sssi methylase. E. coli containing the SssI methylase gene permit the cost-effective production of plasmid DNA for gene therapy with chosen increased percentage of methylated CpG dinucleotides depending on the choice of constitutive promoter, e.g., from 10% to 50% CpG methylation, for applications to DNA vaccination and gene therapy without contamination with a methylase-encoding plasmid DNA construct.

    Abstract translation: 本技术涉及构建在组成型启动子控制下携带毒性基因的染色体拷贝的大肠杆菌细胞株的组合物和方法。 在一些非限制性实例中，毒性基因可以是编码Sssi甲基化酶的基因。 含有SssI甲基化酶基因的大肠杆菌允许成本有效地生产用于基因治疗的质粒DNA，其中所选择的甲基化CpG二核苷酸的百分比取决于组成型启动子的选择，例如10％至5​​0％的CpG甲基化，用于应用 DNA接种和基因治疗，而不会被甲基化酶编码质粒DNA构建体污染​​。

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