公开(公告)号：WO2012178078A2

公开(公告)日：2012-12-27

申请号：PCT/US2012043838

申请日：2012-06-22

Applicant: UNIV NORTH DAKOTA ,  NILLES MATTHEW

Inventor： NILLES MATTHEW

IPC: A61K39/39 ,  A61K38/16 ,  A61K38/17 ,  A61K39/38 ,  A61P31/00 ,  A61P37/00

CPC classification number: A61K39/39 ,  A61K39/0291 ,  A61K2039/55544 ,  G01N33/5055

Abstract: An antigenic composition comprising an antigen and an effective adjuvant, the adjuvant comprising isolated or recombinant YscF, a YscF fragment, trYscF, or homologs thereof. A method of inducing an enhanced immune response comprising administering an antigen and an effective adjuvant comprising isolated or recombinant YscF, a YscF fragment, trYscF, or homologs thereof. An antigenic composition produced by a process comprising providing a host cell with an expression vector containing a nucleotide sequence encoding YscF, a YscF fragment, trYscF, or YscF homolog capable of acting as an adjuvant; expressing the nucleotide sequence in the host cell to produce the protein; and mixing the collected protein with a suitable excipient.

Abstract translation: 包含抗原和有效佐剂的抗原组合物，所述佐剂包含分离或重组的YscF，YscF片段，trYscF或其同系物。 一种诱导增强的免疫应答的方法，包括施用抗原和有效佐剂，其包含分离或重组YscF，YscF片段，trYscF或其同系物。 通过包括向宿主细胞提供含有能够作为佐剂的编码YscF，YscF片段，trYscF或YscF同源物的核苷酸序列的表达载体产生的抗原组合物; 在宿主细胞中表达核苷酸序列以产生蛋白质; 并将收集的蛋白质与合适的赋形剂混合。