公开(公告)号：WO2012178078A2

公开(公告)日：2012-12-27

申请号：PCT/US2012043838

申请日：2012-06-22

Applicant: UNIV NORTH DAKOTA ,  NILLES MATTHEW

Inventor： NILLES MATTHEW

IPC: A61K39/39 ,  A61K38/16 ,  A61K38/17 ,  A61K39/38 ,  A61P31/00 ,  A61P37/00

CPC classification number: A61K39/39 ,  A61K39/0291 ,  A61K2039/55544 ,  G01N33/5055

Abstract: An antigenic composition comprising an antigen and an effective adjuvant, the adjuvant comprising isolated or recombinant YscF, a YscF fragment, trYscF, or homologs thereof. A method of inducing an enhanced immune response comprising administering an antigen and an effective adjuvant comprising isolated or recombinant YscF, a YscF fragment, trYscF, or homologs thereof. An antigenic composition produced by a process comprising providing a host cell with an expression vector containing a nucleotide sequence encoding YscF, a YscF fragment, trYscF, or YscF homolog capable of acting as an adjuvant; expressing the nucleotide sequence in the host cell to produce the protein; and mixing the collected protein with a suitable excipient.

Abstract translation: 包含抗原和有效佐剂的抗原组合物，所述佐剂包含分离或重组的YscF，YscF片段，trYscF或其同系物。 一种诱导增强的免疫应答的方法，包括施用抗原和有效佐剂，其包含分离或重组YscF，YscF片段，trYscF或其同系物。 通过包括向宿主细胞提供含有能够作为佐剂的编码YscF，YscF片段，trYscF或YscF同源物的核苷酸序列的表达载体产生的抗原组合物; 在宿主细胞中表达核苷酸序列以产生蛋白质; 并将收集的蛋白质与合适的赋形剂混合。

公开(公告)号：WO2012178078A3

公开(公告)日：2012-12-27

申请号：PCT/US2012/043838

申请日：2012-06-22

Applicant: UNIVERSITY OF NORTH DAKOTA ,  NILLES, Matthew

Inventor： NILLES, Matthew

IPC: A61K39/39 ,  A61K39/38 ,  A61K38/17 ,  A61K38/16 ,  A61P37/00 ,  A61P31/00

Abstract: An antigenic composition comprising an antigen and an effective adjuvant, the adjuvant comprising isolated or recombinant YscF, a YscF fragment, trYscF, or homologs thereof. A method of inducing an enhanced immune response comprising administering an antigen and an effective adjuvant comprising isolated or recombinant YscF, a YscF fragment, trYscF, or homologs thereof. An antigenic composition produced by a process comprising providing a host cell with an expression vector containing a nucleotide sequence encoding YscF, a YscF fragment, trYscF, or YscF homolog capable of acting as an adjuvant; expressing the nucleotide sequence in the host cell to produce the protein; and mixing the collected protein with a suitable excipient.

公开(公告)号：WO2004082596A2

公开(公告)日：2004-09-30

申请号：PCT/US2004/002852

申请日：2004-01-30

Applicant: UNIVERSITY OF NORTH DAKOTA ,  NILLES, Matthew, L. ,  MATSON, Jyl, S.

Inventor： NILLES, Matthew, L. ,  MATSON, Jyl, S.

IPC: A61K

CPC classification number: C07K16/1228 ,  A61K39/025 ,  A61K2039/505 ,  Y02A50/407

Abstract: A method of protecting an animal from infections with pathogens originating from Yersinia comprising administering an isolated or recombinant YscF protein to the animal is disclosed. The isolated or recombinant YscF protein may be administered as a vaccine. An isolated or recombinant YscF protein capable of conferring protection to an animal against a pathogen of a Yersinia origin is further disclosed. Nucleic acid molecules encoding the isolated or recombinant YscF protein are also disclosed. In other embodiments, antibodies generated against the isolated or recombinant YscF protein capable of conferring protection to an animal against a pathogen or a Yersinia origin and uses of the antibodies are described.

Abstract translation: 公开了一种保护动物免受源自耶尔森氏菌病的病原体的感染的方法，其包括向动物施用分离的或重组的YscF蛋白质。 分离或重组的YscF蛋白可以作为疫苗施用。 进一步公开了能够赋予动物抵抗耶尔森氏菌病原体的分离的或重组的YscF蛋白质。 还公开了编码分离或重组YscF蛋白的核酸分子。 在其它实施方案中，描述了针对分离或重组的YscF蛋白产生的能够赋予动物对耶尔森氏菌来源的病原体和对该抗体的用途的保护的抗体。

公开(公告)号：WO2004082596A3

公开(公告)日：2005-06-02

申请号：PCT/US2004002852

申请日：2004-01-30

Applicant: UNIV NORTH DAKOTA ,  NILLES MATTHEW L ,  MATSON JYL S

Inventor： NILLES MATTHEW L ,  MATSON JYL S

IPC: C07K16/12 ,  A61K39/00 ,  A61K39/02 ,  A61K39/38 ,  C12P21/06

CPC classification number: C07K16/1228 ,  A61K39/025 ,  A61K2039/505

Abstract: A method of protecting an animal from infections with pathogens originating from Yersinia comprising administering an isolated or recombinant YscF protein to the animal is disclosed. The isolated or recombinant YscF protein may be administered as a vaccine. An isolated or recombinant YscF protein capable of conferring protection to an animal against a pathogen of a Yersinia origin is further disclosed. Nucleic acid molecules encoding the isolated or recombinant YscF protein are also disclosed. In other embodiments, antibodies generated against the isolated or recombinant YscF protein capable of conferring protection to an animal against a pathogen of a Yersinia origin and uses of the antibodies are described.

Abstract translation: 公开了一种保护动物免受源自耶尔森氏菌病的病原体的感染的方法，其包括向动物施用分离的或重组的YscF蛋白质。 分离或重组的YscF蛋白可以作为疫苗施用。 进一步公开了能够赋予动物抵抗耶尔森氏菌病原体的分离的或重组的YscF蛋白质。 还公开了编码分离或重组YscF蛋白的核酸分子。 在其它实施方案中，描述了针对分离或重组的YscF蛋白产生的能够赋予动物对耶尔森氏菌来源的病原体和对该抗体的用途的保护的抗体。