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公开(公告)号：WO2012040523A3
公开(公告)日：2012-07-19
申请号：PCT/US2011052854
申请日：2011-09-23
申请人： UNIV ROCKEFELLER , MUIR TOM W , KEE JUNG-MIN
发明人： MUIR TOM W , KEE JUNG-MIN
IPC分类号： C07D249/04 , A61K31/675 , C07F9/38 , C07F9/6518
CPC分类号： C07K16/44 , A61K31/675 , A61K47/646 , C07D249/04 , C07F9/4015 , C07F9/65182 , C07F9/65186 , C07K2317/34
摘要： The present invention relates to the phosphohistidine analogs of the present invention which of the formula (I) and the hapten containing the residue of same. It also relates to the hapten conjugated to a carrier molecule and the isolated antibodies raised against the immunogens, said antibodies recognizing polypeptide containing a phosphorylated histidine or the phosphotriazole residue but it does not recognize an amino acid or polypeptide that is not phosphorylated or a polypeptide which is phosphorylated on amino acids other than histidine but not on histidine.
摘要翻译： 本发明涉及式（I）的本发明的磷酸组氨酸类似物和含有其残基的半抗原。 本发明还涉及偶联于载体分子的半抗原和针对免疫原产生的分离抗体，所述抗体识别含有磷酸化组氨酸或磷酸三唑残基的多肽，但它不识别未磷酸化的氨基酸或多肽或 在组氨酸以外的氨基酸上磷酸化，但不在组氨酸上磷酸化。
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公开(公告)号：WO9967286A2
公开(公告)日：1999-12-29
申请号：PCT/US9914562
申请日：1999-06-24
申请人： UNIV ROCKEFELLER , UNIV NEW YORK , MUIR TOM W , MAYVILLE PATRICIA , NOVICK RICHARD P , JI GUANGYONG , BEAVIS RONALD
发明人： MUIR TOM W , MAYVILLE PATRICIA , NOVICK RICHARD P , JI GUANGYONG , BEAVIS RONALD
摘要： The present invention provides a cyclic peptide comprising structure (I) wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, R is selected from the group consisting of oxygen, nitrogen and carbon, n is 0 to 10 and y is 1 to 10. The present invention also provides a cyclic peptide comprising the amino acid sequence of NH2-X(n)-Z-X(y)-COOH and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is 1 to 10. Methods of preparation including a cyclization protocol, and methods of use of the cyclic peptides of the invention are also disclosed.
摘要翻译： 本发明提供了包含结构（I）的环状肽，其中X选自氨基酸，氨基酸类似物，拟肽和非酰胺异基因，Z选自合成氨基 酸和生物合成氨基酸，R选自氧，氮和碳，n为0至10，y为1至10.本发明还提供了包含NH 2 -X的氨基酸序列的环肽 （n）-ZX（y）-COOH和除了硫酯键之外的Z残基和COOH之间的环键，其中X选自氨基酸，氨基酸类似物，肽模拟物和非 - 酰胺等离子体，Z选自合成氨基酸和生物合成氨基酸，n为0至10，y为1至10.制备方法包括环化方案，以及使用环肽的方法 还公开了本发明。
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公开(公告)号：WO9967286A9
公开(公告)日：2000-05-04
申请号：PCT/US9914562
申请日：1999-06-24
申请人： UNIV ROCKEFELLER , UNIV NEW YORK , MUIR TOM W , MAYVILLE PATRICIA , NOVICK RICHARD P , JI GUANGYONG , BEAVIS RONALD
发明人： MUIR TOM W , MAYVILLE PATRICIA , NOVICK RICHARD P , JI GUANGYONG , BEAVIS RONALD
摘要： The present invention provides a cyclic peptide comprising structure (I) wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, R is selected from the group consisting of oxygen, nitrogen and carbon, n is 0 to 10 and y is 1 to 10. The present invention also provides a cyclic peptide comprising the amino acid sequence of NH2-X(n)-Z-X(y)-COOH and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is 1 to 10. Methods of preparation including a cyclization protocol, and methods of use of the cyclic peptides of the invention are also disclosed.
摘要翻译： 本发明提供了包含结构（I）的环状肽，其中X选自氨基酸，氨基酸类似物，拟肽和非酰胺异基因，Z选自合成氨基 酸和生物合成氨基酸，R选自氧，氮和碳，n为0至10，y为1至10.本发明还提供了包含NH 2 -X的氨基酸序列的环肽 （n）-ZX（y）-COOH和除了硫酯键之外的Z残基和COOH之间的环键，其中X选自氨基酸，氨基酸类似物，肽模拟物和非 - 酰胺等离子体，Z选自合成氨基酸和生物合成氨基酸，n为0至10，y为1至10.制备方法包括环化方案，以及使用环肽的方法 还公开了本发明。
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