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公开(公告)号:WO2005097205A8
公开(公告)日:2007-05-24
申请号:PCT/US2005011232
申请日:2005-04-04
发明人: TUSCHL THOMAS H , PFEFFER SEBASTIEN
IPC分类号: A61K48/00 , C07H21/04 , C07K14/045 , C12N15/11 , C12N15/113 , C12N15/86
CPC分类号: C12N15/1131 , C07H21/04 , C07K14/005 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/11 , C12N2330/10 , C12N2330/31 , C12N2710/16022 , C12N2710/16222 , C12N2710/16422
摘要: The invention relates to an isolated nucleic acid molecule comprising the sequence of a DNA virus microRNA. In another embodiment, the invention relates to isolated single stranded DNA virus microRNA molecules and anti-DNA virus microRNA molecules. In a further embodiment, the invention relates to an isolated microRNP. The invention further provides methods for inhibiting microRNA activity in a cell.
摘要翻译: 本发明涉及包含DNA病毒微小RNA序列的分离的核酸分子。 在另一个实施方案中,本发明涉及分离的单链DNA病毒微小RNA分子和抗DNA病毒微小RNA分子。 在另一个实施方案中,本发明涉及一种分离的microRNP。 本发明还提供抑制细胞中微小RNA活性的方法。
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公开(公告)号:WO2005079397A3
公开(公告)日:2006-06-15
申请号:PCT/US2005004714
申请日:2005-02-11
CPC分类号: C12N15/113 , C12N2310/113 , C12N2310/141 , C12N2310/3145 , C12N2310/315 , C12N2310/321 , C12N2310/3521 , C12N2310/533
摘要: The invention relates to isolated anti-microRNA molecules. In another embodiment, the invention relates to an isolated microRNA molecule. In yet another embodiment, the invention provides a method for inhibiting microRNP activity in a cell.
摘要翻译: 本发明涉及分离的抗微小RNA分子。 在另一个实施方案中,本发明涉及分离的微小RNA分子。 在另一个实施方案中,本发明提供了抑制细胞中的microRNP活性的方法。
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公开(公告)号:WO2005097205A3
公开(公告)日:2009-04-23
申请号:PCT/US2005011232
申请日:2005-04-04
发明人: TUSCHL THOMAS H , PFEFFER SEBASTIEN
IPC分类号: C07H21/04 , A61K48/00 , C07K14/045 , C12N15/11 , C12N15/113 , C12N15/86
CPC分类号: C12N15/1131 , C07H21/04 , C07K14/005 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/11 , C12N2330/10 , C12N2330/31 , C12N2710/16022 , C12N2710/16222 , C12N2710/16422
摘要: The invention relates to an isolated nucleic acid molecule comprising the sequence of a DNA virus microRNA. In another embodiment, the invention relates to isolated single stranded DNA virus microRNA molecules and anti-DNA virus microRNA molecules. In a further embodiment, the invention relates to an isolated microRNP. The invention further provides methods for inhibiting microRNA activity in a cell.
摘要翻译: 本发明涉及包含DNA病毒微小RNA序列的分离的核酸分子。 在另一个实施方案中,本发明涉及分离的单链DNA病毒微小RNA分子和抗DNA病毒微小RNA分子。 在另一个实施方案中,本发明涉及一种分离的microRNP。 本发明还提供抑制细胞中微小RNA活性的方法。
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公开(公告)号:WO2005099770A3
公开(公告)日:2007-04-26
申请号:PCT/US2005010667
申请日:2005-03-30
发明人: STOFFEL MARKUS , POY MATTHEW N , TUSCHL THOMAS H
IPC分类号: C07H21/04 , A61K48/00 , C07H21/02 , C12N15/113 , C12N15/85
CPC分类号: C12N15/113 , C07H21/02 , C12N15/79 , C12N2310/141 , C12N2310/314 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3233 , C12N2310/331 , C12N2310/531 , C12N2320/51 , C12N2330/10
摘要: The invention relates to an isolated DNA or RNA pancreatic islet microRNA molecule. The invention further relates to a modified single stranded pancreatic islet microRNA molecule or an isolated single stranded anti-pancreatic islet microRNA molecule. The invention also provides for hod for inhibiting microRNP activity in a cell.
摘要翻译: 本发明涉及分离的DNA或RNA胰岛微RNA分子。 本发明进一步涉及修饰的单链胰岛微小RNA分子或分离的单链抗胰岛微小RNA分子。 本发明还提供了抑制细胞中的microRNP活性的蛋白质。
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公开(公告)号:WO2016109799A3
公开(公告)日:2016-08-25
申请号:PCT/US2015068287
申请日:2015-12-31
申请人: UNIV ROCKEFELLER , MAX KLAAS , BERTRAM KARL , AKAT KEMAL , TUSCHL THOMAS H , LI JENNY , BOGARDUS KIMBERLY
发明人: MAX KLAAS , BERTRAM KARL , AKAT KEMAL , TUSCHL THOMAS H , LI JENNY , BOGARDUS KIMBERLY
CPC分类号: C07H21/02 , C07H1/08 , C12Q1/6802 , C12Q2527/125
摘要: The disclosure provides methods for isolating nucleic acids from a biological fluid. In one aspect, the disclosure provides a method for isolating RNA. In another aspect, the disclosure provides a method for isolating DNA. In yet another aspect, the disclosure provides a kit for isolating RNA and/or DNA.
摘要翻译: 本公开提供了从生物流体中分离核酸的方法。 一方面,本公开提供了分离RNA的方法。 另一方面,本公开提供了分离DNA的方法。 在另一方面,本公开提供了用于分离RNA和/或DNA的试剂盒。
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