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1.发明申请HYDROGELS FOR COMBINATORIAL DELIVERY OF IMMUNE-MODULATING BIOMOLECULES 审中-公开用于组合输送免疫调节生物分子的HYDROGEL
公开(公告)号：WO2010123971A3
公开(公告)日：2011-03-03
申请号：PCT/US2010031866
申请日：2010-04-21
申请人： UNIV TEXAS , SINGH ANKUR , ROY KRISHNENDU , KASTURI SUDHIR
发明人： SINGH ANKUR , ROY KRISHNENDU , KASTURI SUDHIR
CPC分类号： A61K39/39 , A61K9/06 , A61K38/195 , A61K39/0011 , A61K39/12 , A61K39/292 , A61K47/36 , A61K2039/53 , A61K2039/55511 , A61K2039/55555 , C12N15/1136 , C12N2310/14 , C12N2320/31 , C12N2730/10134
摘要： One embodiment of the current disclosure relates to an immune-modulating composition comprising a hydrogel-forming polymer, an immune-modulating biomolecule operable to recruit or retain an immune cell, and an antigen-related biomolecule. Another embodiment of the current disclosure relates to a method of providing an antigen to an antigen presenting cell in an animal by administering to the animal at an administration site an immune-modulating composition as described above. Next, one forms a hydrogel in-situ from the hydrogel-forming polymer, then recruits at least one antigen presenting cell to the administration site using the immune-modulating biomolecule, and finally inducing phagocytosis of the at least one antigen- related biomolecule by the antigen presenting cell.
摘要翻译： 本公开的一个实施方案涉及包含水凝胶形成聚合物，可操作以募集或保留免疫细胞的免疫调节生物分子和抗原相关生物分子的免疫调节组合物。 本公开的另一个实施方案涉及通过在给药部位向动物施用如上所述的免疫调节组合物来向动物中的抗原呈递细胞提供抗原的方法。 接下来，从形成水凝胶的聚合物原位形成水凝胶，然后使用免疫调节生物分子将至少一种抗原呈递细胞募集到给药部位，最后通过所述免疫调节生物分子诱导至少一种与抗原相关的生物分子的吞噬作用 抗原呈递细胞。
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公开(公告)号：WO2010006200A2
公开(公告)日：2010-01-14
申请号：PCT/US2009050158
申请日：2009-07-09
申请人： UNIV TEXAS , ROY KRISHNENDU , WANAKULE PRINDA , SINGH ANKUR
发明人： ROY KRISHNENDU , WANAKULE PRINDA , SINGH ANKUR
CPC分类号： A61K9/1641 , A61K9/1617 , A61K9/1652
摘要： The present invention includes compositions and methods for the controlled delivery of active agents, e.g., drugs, based on one or more release triggers found in the environment in which the active agent-loaded particle is located. The composition and methods include a polymer network having a polymer cross-linked by peptides that include one or more proteolytic cleavage sites.
摘要翻译： 本发明包括基于在负载活性剂的颗粒所处的环境中发现的一种或多种释放触发剂来控制递送活性剂例如药物的组合物和方法。 组合物和方法包括具有通过包含一个或多个蛋白水解切割位点的肽交联的聚合物的聚合物网络。
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