公开(公告)号：WO2012164103A3

公开(公告)日：2013-01-24

申请号：PCT/EP2012060533

申请日：2012-06-04

Applicant: UNIV ZUERICH ,  SCHWAB MARTIN ,  TEWS BJOERN ,  KEMPF ANISSA

Inventor： SCHWAB MARTIN ,  TEWS BJOERN ,  KEMPF ANISSA

IPC: A61K31/133 ,  A61K31/138 ,  A61K31/4245 ,  A61K31/661

CPC classification number: A61K31/437 ,  A61K31/135 ,  A61K31/166 ,  A61K31/40 ,  A61K31/402 ,  A61K31/415 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/4375 ,  A61K31/47 ,  A61K31/517 ,  A61K31/52 ,  A61K31/662 ,  A61K31/7105 ,  A61K31/713

Abstract: The present invention provides inhibitors capable of binding to a member of the S1PR receptor group comprised of S1PR2 and S1PR5 with a dissociation constant of 5x10-7 mol/l or smaller for treating neuronal damage, specifically an antibody, an antibody fragment, an antibody-like molecule, a nucleic acid aptamer or an oligopeptide with 6 to 30 amino acid residues in length. Similarly, an interfering RNA or an antisense modulator of gene expression of G13 or a member of the S1PR receptor group described above are provided for treating of neuronal damage.

Abstract translation: 本发明提供了能够与S1PR2和S1PR5组成的S1PR受体组成员结合的抑制剂，其解离常数为5×10-7mol / l或更小，用于治疗神经元损伤，具体为抗体，抗体片段，抗体 - 类似分子，核酸适体或长度为6至30个氨基酸残基的寡肽。 类似地，提供上述G13的基因表达或S1PR受体基团的干扰RNA或反义调节剂用于治疗神经元损伤。

公开(公告)号：WO2012164103A9

公开(公告)日：2013-03-21

申请号：PCT/EP2012060533

申请日：2012-06-04

Applicant: UNIV ZUERICH ,  SCHWAB MARTIN ,  TEWS BJOERN ,  KEMPF ANISSA

Inventor： SCHWAB MARTIN ,  TEWS BJOERN ,  KEMPF ANISSA

IPC: A61K31/133 ,  A61K31/138 ,  A61K31/4245 ,  A61K31/661

CPC classification number: A61K31/437 ,  A61K31/135 ,  A61K31/166 ,  A61K31/40 ,  A61K31/402 ,  A61K31/415 ,  A61K31/4245 ,  A61K31/426 ,  A61K31/4375 ,  A61K31/47 ,  A61K31/517 ,  A61K31/52 ,  A61K31/662 ,  A61K31/7105 ,  A61K31/713

Abstract: The present invention provides inhibitors capable of binding to a member of the S1PR receptor group comprised of S1PR2 and S1PR5 with a dissociation constant of 5x10-7 mol/l or smaller for treating neuronal damage, specifically an antibody, an antibody fragment, an antibody-like molecule, a nucleic acid aptamer or an oligopeptide with 6 to 30 amino acid residues in length. Similarly, an interfering RNA or an antisense modulator of gene expression of G13 or a member of the S1PR receptor group described above are provided for treating of neuronal damage.

Abstract translation: 本发明提供能够结合S1PR2和S1PR5的S1PR受体组成员的抑制剂，其解离常数为5×10 -7 mol / l以下，用于治疗神经元损伤，特别是抗体，抗体片段， 类似分子，长度为6至30个氨基酸残基的核酸适体或寡肽。 类似地，提供了用于治疗神经元损伤的干扰RNA或G13基因表达或上述S1PR受体组成员的反义调节剂。