公开(公告)号：WO2014072929A1

公开(公告)日：2014-05-15

申请号：PCT/IB2013/059968

申请日：2013-11-07

Applicant: UNIVERSITY COLLEGE CORK

Inventor： SODEN, Declan ,  O'SULLIVAN, Gerald ,  FORDE, Patrick

IPC: C12N15/85

CPC classification number: C12N15/85 ,  A01K67/0278 ,  A01K2217/072 ,  C07K14/52 ,  C07K14/521 ,  C07K14/535 ,  C12N2800/70 ,  C12N2830/008

Abstract: The present invention provides a non-viral vector which comprises a sequence encoding an RNA replicase and a nuclear localisation sequence. The vector may also comprise a nucleotide sequence of interest (NOI). The vector may be used to deliver an NOI to a target cell.

Abstract translation: 本发明提供了非病毒载体，其包含编码RNA复制酶和核定位序列的序列。 载体还可以包含感兴趣的核苷酸序列（NOI）。 该载体可用于将NOI递送至靶细胞。

公开(公告)号：WO2015170292A1

公开(公告)日：2015-11-12

申请号：PCT/IB2015/053384

申请日：2015-05-08

Applicant: UNIVERSITY COLLEGE CORK

Inventor： SODEN, Declan ,  FORDE, Patrick ,  O'BRIEN, Morgan

IPC: A61K41/00 ,  A61P35/00

CPC classification number: A61K41/0047 ,  A61K38/2013 ,  A61K45/06 ,  A61M37/00 ,  A61M2037/0007

Abstract: The present invention relates to a method for the treatment of cancer in a subject which comprises the steps of: (i) administering electroporation to a tumour in the subject; and (ii) administering a T or B -cell activating agent to the subject, wherein step (i) and (ii) may be performed in either order.

Abstract translation: 本发明涉及一种用于治疗受试者的癌症的方法，其包括以下步骤：（i）对受试者的肿瘤施用电穿孔; 和（ii）向所述受试者施用T或B细胞活化剂，其中步骤（i）和（ii）可以以任何顺序进行。