公开(公告)号：WO2014072929A1

公开(公告)日：2014-05-15

申请号：PCT/IB2013/059968

申请日：2013-11-07

Applicant: UNIVERSITY COLLEGE CORK

Inventor： SODEN, Declan ,  O'SULLIVAN, Gerald ,  FORDE, Patrick

IPC: C12N15/85

CPC classification number: C12N15/85 ,  A01K67/0278 ,  A01K2217/072 ,  C07K14/52 ,  C07K14/521 ,  C07K14/535 ,  C12N2800/70 ,  C12N2830/008

Abstract: The present invention provides a non-viral vector which comprises a sequence encoding an RNA replicase and a nuclear localisation sequence. The vector may also comprise a nucleotide sequence of interest (NOI). The vector may be used to deliver an NOI to a target cell.

Abstract translation: 本发明提供了非病毒载体，其包含编码RNA复制酶和核定位序列的序列。 载体还可以包含感兴趣的核苷酸序列（NOI）。 该载体可用于将NOI递送至靶细胞。

公开(公告)号：WO2014096275A1

公开(公告)日：2014-06-26

申请号：PCT/EP2013/077521

申请日：2013-12-19

Applicant: UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK

Inventor： SODEN, Declan ,  HINCHION, John

IPC: A61N1/32 ,  A61B18/14

CPC classification number: A61N1/325 ,  A61B17/00234 ,  A61B18/1482 ,  A61B2017/00292 ,  A61B2017/00809 ,  A61B2017/00867 ,  A61B2017/308 ,  A61B2018/00291 ,  A61B2018/00541 ,  A61B2018/00613 ,  A61B2018/143 ,  A61B2018/1475 ,  A61N1/0502 ,  A61N1/327

Abstract: A thoracoscopic electroporation device for carrying out electroporation on tissue comprises a suction head (10) and a plurality of needle electrodes. The needle electrodes comprise a central needle (11) providing a first electrode and a plurality of second needles (12, 13, 14, 15, 16, 17) which are spaced-apart around the periphery of the suction head. The second needles are movable from a retracted configuration to a deployed configuration to extend from the suction head. The suction head has a retracted delivery configuration and an expanded deployed configuration. The suction head comprises a suitable flexible material and biasing means (20) for biasing the suction head into the expanded deployed configuration. The suction head has channels (21) for the needles and the needles are movable through the channels from the retracted to the deployed configuration. In the deployed configuration, the central first needle extends beyond the second needles. A vacuum is applied by drawing air out through the central first needle. A therapeutic agent may be applied to the tissue before, during, or after electroporation.

Abstract translation: 用于在组织上进行电穿孔的胸腔镜电穿孔装置包括吸头（10）和多个针电极。 针电极包括提供第一电极的中心针（11）和围绕吸头的周边间隔开的多个第二针（12,13,14,15,16,17）。 第二针可从缩回构型移动到展开构型以从吸头延伸。 吸头具有缩回的传送配置和扩展的部署配置。 吸头包括合适的柔性材料和偏压装置（20），用于将吸头偏置成扩展展开构型。 吸头具有用于针的通道（21），并且针可以通过通道从缩回到展开构型移动。 在展开配置中，中央第一针延伸超过第二针。 通过中央的第一针抽出空气来施加真空。 在电穿孔之前，期间或之后，可将治疗剂施用于组织。

公开(公告)号：WO2015170292A1

公开(公告)日：2015-11-12

申请号：PCT/IB2015/053384

申请日：2015-05-08

Applicant: UNIVERSITY COLLEGE CORK

Inventor： SODEN, Declan ,  FORDE, Patrick ,  O'BRIEN, Morgan

IPC: A61K41/00 ,  A61P35/00

CPC classification number: A61K41/0047 ,  A61K38/2013 ,  A61K45/06 ,  A61M37/00 ,  A61M2037/0007

Abstract: The present invention relates to a method for the treatment of cancer in a subject which comprises the steps of: (i) administering electroporation to a tumour in the subject; and (ii) administering a T or B -cell activating agent to the subject, wherein step (i) and (ii) may be performed in either order.

Abstract translation: 本发明涉及一种用于治疗受试者的癌症的方法，其包括以下步骤：（i）对受试者的肿瘤施用电穿孔; 和（ii）向所述受试者施用T或B细胞活化剂，其中步骤（i）和（ii）可以以任何顺序进行。

公开(公告)号：WO2011030322A2

公开(公告)日：2011-03-17

申请号：PCT/IE2010/000053

申请日：2010-09-10

Applicant: UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK ,  SODEN, Declan

Inventor： SODEN, Declan

IPC: A61N1/32 ,  C12M3/00 ,  A61B18/18 ,  A61B1/005 ,  A61N5/00

CPC classification number: A61N1/327 ,  A61B1/005 ,  A61B18/18 ,  A61N1/0512 ,  A61N5/04 ,  A61N5/1002

Abstract: An apparatus for use in carrying out a prophylactic or treatment procedure on tissue comprises a head piece 1 having a receiver 2 for receiving an instrument such as an endoscope 10 and chamber 3 into which tissue is drawn by vaccum. There are two electrodes 11 within the chamber 2 and two electrodes 25 located on opposite sides of the entrance 5 into the chamber. The voltage applied to the inner and outer electrodes 11, 25 can be varied independently an allows tissue underlying the device to be treated. This is particularly important for colorectal cancers.

Abstract translation: 用于在组织上执行预防或治疗过程的装置包括具有用于接收诸如内窥镜10的仪器的接收器2的头部件1和通过真空抽吸组织的腔室3。 在腔室2内有两个电极11和位于入口5的相对两侧的两个电极25进入腔室。 施加到内电极11和外电极25的电压可以独立地变化，允许待处理的器件下方的组织。 这对结肠直肠癌特别重要。

公开(公告)号：WO2005092433A1

公开(公告)日：2005-10-06

申请号：PCT/IE2005/000030

申请日：2005-03-24

Applicant: UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK ,  MORRISSEY, Anthony ,  SODEN, Declan ,  O'SULLIVAN, Gerald ,  COLLINS, Christopher ,  DUNNE, Colum ,  PIGGOTT, John ,  PRIOR, Denton ,  WATSON, Andrew ,  MCGEEHIN, Peter

Inventor： MORRISSEY, Anthony ,  SODEN, Declan ,  O'SULLIVAN, Gerald ,  COLLINS, Christopher ,  DUNNE, Colum ,  PIGGOTT, John ,  PRIOR, Denton ,  WATSON, Andrew ,  MCGEEHIN, Peter

IPC: A61N1/18

CPC classification number: C12M35/02 ,  A61B18/1477 ,  A61B18/1492 ,  A61B2018/0016 ,  A61B2018/00291 ,  A61B2018/00482 ,  A61B2018/00494 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2218/002 ,  A61N1/0424 ,  A61N1/0476 ,  A61N1/327 ,  A61N5/0601 ,  A61N5/062

Abstract: Apparatus (20) for carrying out a prophylactic or treatment procedure on tissue comprises a device (21) having a chamber (22) and at least one active element such as an electrode (23) within the chamber (22). The chamber (22) has an opening (26) through which tissue is drawn into the chamber (22). Means for drawing the tissue into the chamber may comprise a vacuum lumen with vacuum orifices (25) in the chamber (22). Treatment such as electroporation may be applied to tissue in the chamber (22).

Abstract translation: 用于在组织上执行预防或治疗过程的装置（20）包括在腔室（22）内具有腔室（22）和至少一个有源元件（例如电极（23））的装置（21）。 腔室（22）具有一个开口（26），组织被吸入腔室（22）中。 用于将组织拉入腔室的装置可以包括在腔室（22）中具有真空孔（25）的真空腔。 诸如电穿孔的治疗可以施加到腔室（22）中的组织。