公开(公告)号：WO2019100053A1

公开(公告)日：2019-05-23

申请号：PCT/US2018/061971

申请日：2018-11-20

Applicant: UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

Inventor： YIN, Hang ,  XIE, Liwei ,  YIN, Amelia Yao-Ye

IPC: A61P21/04 ,  A61K31/015 ,  A61K31/277

CPC classification number: A61K31/7105 ,  A61K9/0019 ,  A61K31/015 ,  A61K31/277 ,  A61P21/04 ,  A61P25/14 ,  C12Q1/6876

Abstract: Compositions and methods for modulating HIF-2α to meditate of hypoxia signaling in satellite cells and applications thereof for improving skeletal muscle generation and repair are provided. For example, methods of enhancing, increasing, accelerating or/and otherwise improving skeletal muscle generation or regeneration in a subject in need thereof are disclosed. In some embodiments, the methods include administering the subject an effective amount of HIF-2α inhibitor. The HIF-2α inhibitor can be effective to, for example, increase muscle satellite cell proliferation, differentiation, or a combination thereof in a subject. Composition and methods for improving respiration, and reducing or preventing the development or progression of fibrosis are also provided. The disclosed compositions and methods are particularly useful for treating muscular dystrophies, myopathies, and other muscle-related diseases and disorders.