公开(公告)号：WO2003089615A3

公开(公告)日：2003-10-30

申请号：PCT/US2003/012260

申请日：2003-04-22

申请人： UNIVERSITY OF MARYLAND, BALTIMORE COUNTY

发明人： SUMMERS, Michael, F. ,  TANG, Chun ,  HUANG, Mingjun

IPC分类号： C12Q1/70

摘要： Methods for evaluating the antiviral activity of test compounds are provided. Further aspects of the methods involve the retroviral capsid protein of HIV-1. In another aspect, methods of reducing mortality associated with AIDS with a compound that binds to the apical cleft near the C-terminal end of the N-terminal domain of the HIV-1 capsid protein are provided. Derivatives of CAP-1, CAP-2, CAP-3, CAP-4, CAP-5, CAP-6 and CAP-7 are described that bind to the apical cleft of the N-terminal domain of the HIV-1 capsid protein and inhibit proper assembly of the core particle.

公开(公告)号：WO2003089615A2

公开(公告)日：2003-10-30

申请号：PCT/US2003/012260

申请日：2003-04-22

申请人： UNIVERSITY OF MARYLAND, BALTIMORE COUNTY

发明人： SUMMERS, Michael, F. ,  TANG, Chun ,  HUANG, Mingjun

IPC分类号： C12N

CPC分类号： C07K14/005 ,  A61K31/00 ,  A61K31/17 ,  A61K31/277 ,  A61K31/341 ,  C07C275/30 ,  C07C275/32 ,  C07C275/40 ,  C07C275/42 ,  C07C281/06 ,  C07D307/52 ,  C12N2740/16222 ,  C12Q1/18 ,  C40B30/02 ,  G01N2500/04 ,  G06F19/16 ,  G06F19/706 ,  Y02A90/26

摘要： Methods for evaluating the antiviral activity of test compounds are provided. Further aspects of the methods involve the retroviral capsid protein of HIV-1. In another aspect, methods of reducing mortality associated with AIDS with a compound that binds to the apical cleft near the C-terminal end of the N-terminal domain of the HIV-1 capsid protein are provided. Derivatives of CAP-1, CAP-2, CAP-3, CAP-4, CAP-5, CAP-6 and CAP-7 are described that bind to the apical cleft of the N-terminal domain of the HIV-1 capsid protein and inhibit proper assembly of the core particle.

摘要翻译： 提供了评价试验化合物的抗病毒活性的方法。 方法的其他方面涉及HIV-1的逆转录病毒衣壳蛋白。 另一方面，提供了与HIV-1衣壳蛋白的N-末端结构域的C-末端附近的与顶端裂缝结合的化合物降低与AIDS相关的死亡率的方法。 描述了结合到HIV-1衣壳蛋白的N-末端结构域的顶端裂口的CAP-1，CAP-2，CAP-3，CAP-4，CAP-5，CAP-6和CAP-7的衍生物 并抑制核心颗粒的正确组装。