摘要:
This document discloses molecules having the following formula ("Formula One") and processes to produce molecules that are useful as pesticides (e.g., acaricides, insecticides, molluscicides, and nematicides ), such molecules, and processes of using such molecules to control pests. Pests cause millions of human deaths around the world each year. Furthermore, there are more than ten thousand species of pests that cause losses in agriculture. The world-wide agricultural losses amount to billions of U.S. dollars each year. Termites cause damage to all kinds of private and public structures. The world-wide termite damage losses amount to billions of U.S. dollars each year.
摘要:
Disclosed are compounds of formulae (I), (III), (IV), (VII), (X), (XI), (XII), (XIII) and (XIV), wherein the variabables are as defined in the claims, and methods of using compounds of the invention for treating a subject with a proliferative disorder, such as cancer, and methods for treating disorders responsive to Hsp70 induction and/or natural killer induction. Also disclosed are pharmaceutical compositions comprising compounds of the invention and a pharmaceutically acceptable carrier.
摘要:
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要:
Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要:
Methods for evaluating the antiviral activity of test compounds are provided. Further aspects of the methods involve the retroviral capsid protein of HIV-1. In another aspect, methods of reducing mortality associated with AIDS with a compound that binds to the apical cleft near the C-terminal end of the N-terminal domain of the HIV-1 capsid protein are provided. Derivatives of CAP-1, CAP-2, CAP-3, CAP-4, CAP-5, CAP-6 and CAP-7 are described that bind to the apical cleft of the N-terminal domain of the HIV-1 capsid protein and inhibit proper assembly of the core particle.
摘要:
Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction, in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory diseases, immunological diseases and cancer.
摘要:
Novel acyl urea, thiourea, carbamate, thiocarbamate and related compounds are provided which are effective in inhibiting the cytokine-mediated inflammatory response in cultured cells, in ameliorating bone destruction, in an animal model of arthritis and in lowering blood glucose levels in animal models of Type II diabetes mellitus. The compounds are disclosed as useful for a variety of treatments including the treatment of diabetes mellitus, insulin resistance, inflammation, inflammatory diseases, immunological diseases and cancer.
摘要:
The invention concerns novel arylalkyl compounds of general formula (I) in which Q stands for O, S, SO or SO2, R stands for hydrogen or optionally substituted alkyl, R stands for hydrogen or optionally substituted alkyl, Z stands for one of the groups: (a), (b), (c), and (Y)n, (X)m, R , R , R , R , R and R stand for hydrogen or given substituents. The invention also concerns processes for preparing these compounds, novel intermediate products, and the use of the arylalkyl compounds as herbicides.
摘要:
Processes are disclosed for preparing compounds of Formula (I), for preparing a compound of Formula (II), for preparing a compound of Formula (III) and for preparing a compound of Formula (IV), wherein R and R are each independently H, halogen, cyano, nitro, C1-C6 alkyl, C1-C6 haloalkyl, C2-C6 alkenyl, C2-C6 haloalkenyl, C2-C6 alkynyl, C2-C6 haloalkynyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C2-C6 alkenyloxy, C2-C4 alkoxycarbonyl; or C2-C6 alkynyloxy; R is H or C1-C3 alkyl, Lg is halogen, acetoxy, OSO2Q or (a); Q is C1-C6 alkyl, C1-C6 alkenyl, or phenyl optionally substituted with C1-C3 alkyl; R is C1-C6 alkyl, C1-C6 alkenyl or phenyl; and Z, R and R are as defined in the disclosure. Also disclosed are advantageous process sequences and process conditions; as well as novel compounds of Formula (III) and novel compounds of Formula (IV).