公开(公告)号：WO2015171622A1

公开(公告)日：2015-11-12

申请号：PCT/US2015/029258

申请日：2015-05-05

Applicant: UNIVERSITY OF MISSISSIPPI MEDICAL CENTER

Inventor： ELSHAMY, Wael M.

IPC: A61K38/16 ,  A61K38/00 ,  C07K16/00 ,  C12N15/11

CPC classification number: C07K14/00 ,  A61K31/337 ,  A61K31/713 ,  A61K33/24 ,  A61K38/00 ,  A61K45/06 ,  A61K47/645 ,  C07K14/4703 ,  C07K2319/10 ,  C12N15/1135 ,  C12N2310/14 ,  C12N2310/531 ,  A61K2300/00

Abstract: The present disclosure relates to peptides for treating cancer, wherein the peptides suppress BRCA1-IRIS expression or activity. The peptides may include an amino acid sequence as set forth in SEQ ID NO: 1 and/or SEQ ID NO: 2. Further, the present disclosure provides methods for treating cancer, wherein the cancer may be breast or ovarian cancer, including administering one of said peptides to a subject in need thereof.

Abstract translation: 本公开涉及用于治疗癌症的肽，其中所述肽抑制BRCA1-IRIS表达或活性。 肽可以包括如SEQ ID NO：1和/或SEQ ID NO：2所示的氨基酸序列。此外，本公开提供了治疗癌症的方法，其中所述癌症可以是乳腺癌或卵巢癌，包括给予一种 的所述肽。