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    A VIRTUAL IMMERSIVE SENSORIMOTOR DEVICE AND METHODS TO DETECT NEUROLOGICAL IMPAIRMENTS
    1.
    发明申请
    A VIRTUAL IMMERSIVE SENSORIMOTOR DEVICE AND METHODS TO DETECT NEUROLOGICAL IMPAIRMENTS 审中-公开

    公开(公告)号：WO2022212798A1

    公开(公告)日：2022-10-06

    申请号：PCT/US2022/022966

    申请日：2022-03-31

    Applicant: UNIVERSITY OF MISSISSIPPI MEDICAL CENTER

    Inventor： RENEKER, Jennifer ,  PRUETT, William

    IPC: A61B5/11 ,  A61B5/113 ,  A61B5/16 ,  A61B5/1114 ,  A61B5/163 ,  A61B5/4064 ,  A61B5/7267 ,  G06F3/012 ,  G06F3/013 ,  G06T15/00 ,  G06T2210/41 ,  H04N13/344

    Abstract: Provided herein are a method of detecting neurological impairment and a device for testing sensorimotor control to detect neurological impairment. The method includes positioning a head-mounted display on the user's head, the head-mounted display placing the user in a virtual or augmented reality environment; presenting the subject with a software-generated object in the virtual or augmented reality environment; providing instructions directing the user to execute one or more sensorimotor activities relating to the software-generated object within the virtual or augmented reality environment; recording data during execution of the one or more objectives; and determining if there is a neurological impairment based upon the recorded data. The device includes a head-mounted display, one or more processors, and one or more hardware storage devices having stored thereon computer-executable instructions which are executable by the one or more processors to display a virtual immersive environment in the head-mounted display.

    PRODUCTION OF SIZED MACRO- AND MICRO- ELP PARTICLES FOR DRUG DELIVERY
    3.
    发明申请
    PRODUCTION OF SIZED MACRO- AND MICRO- ELP PARTICLES FOR DRUG DELIVERY 审中-公开

    公开(公告)号：WO2019236769A1

    公开(公告)日：2019-12-12

    申请号：PCT/US2019/035674

    申请日：2019-06-05

    Applicant: UNIVERSITY OF MISSISSIPPI MEDICAL CENTER

    Inventor： JANORKAR, Amol ,  COBB, Jared ,  CORREIA, John ,  ZAI-ROSE, Valeria

    IPC: A61K38/39 ,  C07K14/78

    Abstract: Elastin-like polymers (ELP) are shown to demonstrate dynamic behavior atop silica, simillar to visco-elastic polymer dewetting. A combination of multiple factors are shown to contribute to this behavior including the hydrophilicity of the silica preventing the adsorption of ELP, the formation of a salt layer between ELP and silica, and the ability of the silica and salt layer to hold on to minute amounts of water for prolonged periods. Further, the addition of a polyethyleneimine (PEI) block to the terminal end of ELP allows the particle radius as well as LCST to be controlled by changing any combination of polymer concentration, NaCl concentration, and pH. The addition of the PEI block also provides the ability to crosslink the copolymers and achieve a stable particle radius after formation in harsh environments.

    KIDNEY-TARGETED DRUG DELIVERY SYSTEMS
    4.
    发明申请
    KIDNEY-TARGETED DRUG DELIVERY SYSTEMS 审中-公开
    KIDNEY针对性药物递送系统

    公开(公告)号：WO2016077618A1

    公开(公告)日：2016-05-19

    申请号：PCT/US2015/060438

    申请日：2015-11-12

    Applicant: UNIVERSITY OF MISSISSIPPI MEDICAL CENTER

    Inventor： CHADE, Alejandro R. ,  BIDWELL III, Gene L.

    IPC: A61K8/04

    CPC classification number: A61K47/64 ,  A61K38/1866 ,  A61K38/39 ,  A61K47/6435 ,  A61P13/12 ,  A61K2300/00

    Abstract: A composition including an elastin-like polypeptide (ELP) coupled to a kidney targeting peptide and. a therapeutic agent is provided. A method of delivering a therapeutic agent to a subject in need thereof, comprising: administering to the subject an effective amount of a composition comprising: an elastin-like polypeptide (ELP), a kidney targeting agent coupled to the ELP and a targeting agent and / or a drug binding domain coupled to the ELP, wherein the ELP includes an amino acid sequence having at least about repeats of the amino acid sequence GVPGX (SEQ ID NO: 1 ), and wherein the composition enhances the deposition and retention of the therapeutic agent in the kidney relative to the non-conjugated therapeutic.

    Abstract translation: 包含与肾靶向肽偶联的弹性蛋白样多肽（ELP）的组合物。 提供治疗剂。 一种向有需要的受试者递送治疗剂的方法，包括：向所述受试者施用有效量的组合物，所述组合物包含：弹性蛋白样多肽（ELP），与所述ELP偶联的肾靶向剂和靶向剂，以及 /或与ELP偶联的药物结合结构域，其中所述ELP包括具有氨基酸序列GVPGX（SEQ ID NO：1）的至少约一个重复序列的氨基酸序列，并且其中所述组合物增强所述治疗剂的沉积和保留 药物在肾脏相对于非共轭治疗。

    METHOD OF PREPARING DELTA-9 TETRAHYDROCANNABINOL
    5.
    发明申请
    METHOD OF PREPARING DELTA-9 TETRAHYDROCANNABINOL 审中-公开

    公开(公告)号：WO2003061563A3

    公开(公告)日：2003-07-31

    申请号：PCT/US2002/037488

    申请日：2002-11-22

    Applicant: UNIVERSITY OF MISSISSIPPI MEDICAL CENTER

    Inventor： ELSOHLY, Mahmoud, A. ,  ROSS, Samir. A.

    IPC: G01N1/40

    Abstract: A method for the isolation of delta-9-tetrahydrocannibinol (THC) from Cannabis plant material, wherein delta-9-THC Acid and THC are separately obtained comprising the steps of extracting the Cannabis plant material, chelating delta-9-THC acid on alumina solid support from cannabis extracts rich in the acid washing of non-acid washing of non-acid components of the extract with organic solvents and eluting of the delta-9-THC acid with strong polar solvents. MThe method also includes a process by which to increase the THC content and decrease the weight of Cannabis extracts or residue from distillation of Cannabis extracts containing a low concentration of THC, comprising treatment of such materials with watermissible organic solvents followed by filtration and evaporation of the solvent to obtain the concentrated residue.

    MEDICAL IMAGE PROCESSING METHOD
    8.
    发明申请
    MEDICAL IMAGE PROCESSING METHOD 审中-公开
    医学图像处理方法

    公开(公告)号：WO2014201052A2

    公开(公告)日：2014-12-18

    申请号：PCT/US2014/041793

    申请日：2014-06-10

    Applicant: UNIVERSITY OF MISSISSIPPI MEDICAL CENTER

    Inventor： SMITH, Andrew

    IPC: G06F19/00

    CPC classification number: G06T11/001 ,  G06T5/002 ,  G06T7/0012 ,  G06T2207/10072 ,  G06T2207/20182 ,  G06T2210/41

    Abstract: The present disclosure provides methods for colorizing and/or standardizing a medical image, comprising, for example, the steps of (i) receiving, in an image processing unit, digital image data obtained by an image capture device, wherein the digital image data includes a medical image; (ii) analyzing the data with the image processing unit to identify a region of interest; (iii) segmenting said region of interest; (iv) obtaining a measure of the pixel intensities in the segmented region of interest; (v) selecting an optimized color spectrum from a plurality of color spectra using the result of the measure of the pixel intensities in the segmented region of interest; (vi) colorizing the digital image data by mapping the selected color spectrum to the region of interest; and (vii) displaying the colorized medical image.

    Abstract translation: 本公开提供了用于使医学图像着色和/或标准化的方法，包括例如以下步骤：（i）在图像处理单元中接收由图像捕获装置获得的数字图像数据，其中数字图像数据包括 医学形象; （ii）利用图像处理单元分析数据以识别感兴趣的区域; （iii）分割所述感兴趣的区域; （iv）获得所分割的感兴趣区域中的像素强度的度量; （v）使用感兴趣的分割区域中的像素强度的测量结果从多个色谱中选择优化的色谱; （vi）通过将所选择的色谱映射到感兴趣的区域来对数字图像数据进行着色; 和（vii）显示彩色医疗图像。

    USE OF IL-2 RECEPTOR ANTIBODIES
    9.
    发明申请
    USE OF IL-2 RECEPTOR ANTIBODIES 审中-公开
    IL-2受体抗体的使用

    公开(公告)号：WO2004030685A2

    公开(公告)日：2004-04-15

    申请号：PCT/EP2003/010888

    申请日：2003-10-01

    Applicant: F. HOFFMANN-LA ROCHE AG ,  THE UNIVERSITY OF MISSISSIPPI ,  THE UNIVERSITY OF MISSISSIPPI MEDICAL CENTER

    Inventor： CHAPMAN, Stanley, Willetts ,  CLEARY, John, D. ,  GORDON, Robert, D.

    IPC: A61K38/00

    CPC classification number: A61K31/7048 ,  A61K39/3955 ,  A61K2300/00

    Abstract: This invention relates to a method for treating a patient having a fungal infection. The invention comprises administering to the patient a therapeutically effective amount of a polyene antifungal (e.g., amphotericin B) in association with a therapeutically effective amount of a interleukin-2 inhibitor (e.g., chimeric or humanized monoclonal antibody that binds to the p55 subunit of the human interleukin-2 receptor and inhibits binding of interleukin-2 to an interleukin-2 receptor).

    Abstract translation: 本发明涉及一种治疗患有真菌感染的患者的方法。 本发明包括向患者施用治疗有效量的多烯抗真菌剂（例如两性霉素B），其与治疗有效量的白细胞介素-2抑制剂（例如，嵌合或人源化单克隆抗体结合，其与p55亚基的p55亚基结合 人白细胞介素-2受体并抑制白细胞介素-2与白细胞介素-2受体的结合）。

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