公开(公告)号：WO1992019264A1

公开(公告)日：1992-11-12

申请号：PCT/US1992003675

申请日：1992-05-01

Applicant: UNIVERSITY OF NEW MEXICO

Inventor： UNIVERSITY OF NEW MEXICO ,  BORN, Jerry, L. ,  ESHIMA, Dennis ,  MANN, Paul, L. ,  MATWIYOFF, Nicholas, A. ,  KROH, Frank, O.

IPC: A61K39/02

CPC classification number: A61K49/085 ,  A61K47/6415 ,  A61K49/10 ,  A61K49/14 ,  A61K51/0497 ,  A61K51/08 ,  A61K51/081 ,  A61K2121/00 ,  A61K2123/00

Abstract: Biomodulators, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators can also condition tissue to enhance uptake of otherwise non-specific imaging agents. When linked to drugs, biomodulators can target the same to particular sites in the body. Biomodulators can be also administered together with an agent such as a drug or an imaging agent (specific or non-specific) structurally modified to take advantage of perturbations of cell oligosaccharide displays caused by biomodulators, to enhance images of a host, e.g., NMR-, X-ray- or radio-images, preferably by increasing aberrant tissue signal intensity. Biomodulators condition tissue to enhance or otherwise modify up-take of the drug or structurally modified agent.

Abstract translation: 优选通过增加异常组织信号强度，任选地与成像活性部分连接的生物调节剂可以施用于宿主以增强其图像，例如NMR-，X射线或放射图像。 生物调节剂还可以调节组织以增强非特异性成像剂的吸收。 当与药物相关时，生物调节剂可以将其靶向到身体中的特定部位。 生物调节剂还可与诸如药物或成像剂（特异性或非特异性）的试剂一起施用，其结构修饰以利用由生物调节剂引起的细胞寡糖显示的扰动，以增强宿主的图像，例如NMR- ，X射线或放射线图像，优选通过增加异常组织信号强度。 生物调节剂调节组织以增强或以其它方式改变药物或结构改性剂的摄取。

公开(公告)号：WO1992019213A2

公开(公告)日：1992-11-12

申请号：PCT/US1992003667

申请日：1992-05-01

Applicant: UNIVERSITY OF NEW MEXICO

Inventor： UNIVERSITY OF NEW MEXICO ,  BORN, Jerry, L. ,  ESHIMA, Dennis ,  MANN, Paul, L. ,  MATWIYOFF, Nicholas, A. ,  RHODES, Buck, A.

IPC: A61K0

CPC classification number: A61K49/16 ,  A61K47/6415 ,  A61K49/085 ,  A61K49/14 ,  A61K51/08 ,  A61K51/081 ,  A61K51/1033 ,  A61K51/1045 ,  A61K51/1087 ,  A61K2123/00

Abstract: Biomodulators, in conjuction with antibodies, tumor-specific agents or conjugates thereof, optionally linked to imaging-active moieties, can be administered to a host to enhance images thereof, e.g., NMR-, X-Ray- or radioimages, preferably by increasing aberrant tissue signal intensity.

Abstract translation: 结合抗体的生物调节剂，任选与成像活性部分连接的肿瘤特异性试剂或其缀合物可以施用于宿主以增强其图像，例如NMR-，X射线或放射线图像，优选通过增加异常 组织信号强度。