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    CARTILAGE-HOMING PEPTIDES
    2.
    发明申请
    CARTILAGE-HOMING PEPTIDES 审中-公开
    软骨致神经肽

    公开(公告)号：WO2017044894A3

    公开(公告)日：2017-05-11

    申请号：PCT/US2016051166

    申请日：2016-09-09

    申请人： HUTCHINSON FRED CANCER RES ,  BLAZE BIOSCIENCE INC

    发明人： OLSON JAMES ,  STRAND ANDREW DAVID ,  GIRARD EMILY JUNE ,  STRONG ROLAND ,  MEHLIN CHRISTOPHER ,  CORRENTI COLIN ,  NAIRN NATALIE

    IPC分类号： A61K38/16 ,  A61K47/62 ,  A61K47/64 ,  A61K51/08 ,  C07K14/00 ,  C07K14/435 ,  C07K14/51

    CPC分类号： A61K49/0056 ,  A61K31/573 ,  A61K47/64 ,  A61K49/0032 ,  A61K51/08

    摘要： Peptides that home, target, migrate to, are directed to, are retained by, or accumulate in amd/or binds to the cartilage of a subject are disclosed. Pharmaceutical compositions and uses for peptides or peptide- active agent complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of a drug to a target region, tissue, structure or cell in the cartilage. Targeted compositions of the disclosure can deliver peptide or peptide- active agent complexes to target regions, tissues, structures or cells targeted by the peptide.

    摘要翻译： 公开了归属，靶向，迁移到，被引导，保留，或累积和/或结合到受试者软骨的肽。 还公开了包含这些肽的药物组合物和肽或肽 - 活性剂复合物的用途。 可配制这样的组合物用于将药物靶向递送至软骨中的目标区域，组织，结构或细胞。 本公开内容的靶向组合物可将肽或肽 - 活性剂复合物递送至靶向肽的靶区域，组织，结构或细胞。

    GRPR-ANTAGONISTS FOR DETECTION, DIAGNOSIS AND TREATMENT OF GRPR-POSITIVE CANCER
    8.
    发明申请
    GRPR-ANTAGONISTS FOR DETECTION, DIAGNOSIS AND TREATMENT OF GRPR-POSITIVE CANCER 审中-公开
    用于GRPR阳性癌检测，诊断和治疗的GRPR拮抗剂

    公开(公告)号：WO2014052471A1

    公开(公告)日：2014-04-03

    申请号：PCT/US2013/061712

    申请日：2013-09-25

    申请人： BIOSYNTHEMA INC.

    发明人： MAINA-NOCK, Theodosia ,  NOCK, Berthold, Artur ,  DE JONG HENDRIKS, Marion

    IPC分类号： A61K51/08 ,  A61P35/00 ,  C07B59/00

    CPC分类号： A61K51/088 ,  A61K51/08 ,  C07B59/008

    摘要： The present invention relates to probes for use in the detection, imaging, diagnosis, targeting, treatment, etc. of cancers expressing the gastrin releasing peptide receptor (GRPR). For example, such probes may be molecules conjugated to detectable labels which are preferably moieties suitable for detection by gamma imaging and SPECT or by positron emission tomography (PET) or magnetic resonance imaging (MRI) or fluorescence spectroscopy or optical imaging methods.

    摘要翻译： 本发明涉及用于表达胃泌素释放肽受体（GRPR）的癌症的检测，成像，诊断，靶向，治疗等的探针。 例如，这样的探针可以是缀合到可检测标记的分子，其优选适合于通过γ成像和SPECT或正电子发射断层摄影（PET）或磁共振成像（MRI）或荧光光谱学或光学成像方法进行检测的部分。

    RADIOLABELED PROBES FOR THE NON-INVASIVE DETECTION AND IMAGING OF CELL DEATH
    9.
    发明申请
    RADIOLABELED PROBES FOR THE NON-INVASIVE DETECTION AND IMAGING OF CELL DEATH 审中-公开
    用于非侵入性检测和细胞死亡成像的放射性探针

    公开(公告)号：WO2014011327A1

    公开(公告)日：2014-01-16

    申请号：PCT/US2013/043067

    申请日：2013-05-29

    申请人： DANA-FARBER CANCER INSTITUTE, INC. ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

    发明人： KUNG, Andrew ,  DEGRADO, Timothy

    IPC分类号： C12Q1/32 ,  C12N9/04 ,  A61K51/00 ,  A61K51/08

    CPC分类号： C12Q1/32 ,  A61K51/08 ,  G01N2800/70

    摘要： The invention provides compounds and methods of their use in the detection of apoptosis and necrosis. The compounds and methods are based on conjugates formed with a dehydrogenase such as lactate dehydrogenase, alcohol dehydrogenase, aldehyde dehydrogenase, and malate dehydrogenase. The compounds and methods are useful in the diagnosis of conditions characterized by apoptosis, including cancer, cardiac disease, neurologic disease including stroke, and autoimmunity.

    摘要翻译： 本发明提供了它们用于检测凋亡和坏死的化合物和方法。 化合物和方法基于与脱氢酶形成的缀合物，例如乳酸脱氢酶，醇脱氢酶，醛脱氢酶和苹果酸脱氢酶。 该化合物和方法可用于诊断特征为细胞凋亡的病症，包括癌症，心脏病，神经系统疾病，包括中风和自身免疫。