公开(公告)号：WO2006009835A1

公开(公告)日：2006-01-26

申请号：PCT/US2005/021441

申请日：2005-06-17

Applicant: UNIVERSITY OF PITTSBURGH ,  FLUOROUS TECHNOLOGIES INC

Inventor： CURRAN, Dennis, P. ,  MATSUGI, Masato ,  YU, Marvin, S.

IPC: C07D217/06

CPC classification number: C07C17/263 ,  C07B39/00 ,  C07C17/38 ,  C07C21/18 ,  C07C22/08 ,  C07C67/56 ,  Y10T436/13 ,  Y10T436/19 ,  C07C69/63

Abstract: A method of separating at least a first non-fluorous compound from a mixture of compounds including at least the first non-fluorous compound and a second fluorous compound includes: charging the of compounds to a non-fluorous solid (stationary) phase and eluting with a fluorous eluting fluid (mobile phase). In one embodiment, the non-fluorous solid phase is polar in nature. The method can further include a second phase elution with a suitable organic solvent. A method conducting a chemical reaction, includes: mixing at least a first fluorous compound and a second compound, the first fluorous compound differing in fluorous nature from the second compound; exposing the first mixture to conditions to convert at least one of the first fluorous compound and the second compound to give a second mixture containing at least a third compound, charging the second mixture to a non-fluorous solid phase; and eluting with a fluorous fluid.

Abstract translation: 从至少包含第一非氟化合物和第二氟化合物的化合物的混合物中分离至少第一非氟化合物的方法包括：将化合物装入非氟固体（固定）相，并用 氟洗脱液（流动相）。 在一个实施方案中，非氟固体本质上是极性的。 该方法还可以包括用合适的有机溶剂进行第二相洗脱。 进行化学反应的方法包括：将至少第一氟化合物和第二化合物混合，所述第一氟化合物与所述第二化合物不同; 将第一混合物暴露于转化至少一种第一种氟化合物和第二种化合物的条件以产生含有至少第三种化合物的第二混合物，将第二种混合物装入非氟固体; 并用氟液洗脱。