公开(公告)号：WO2017181186A1

公开(公告)日：2017-10-19

申请号：PCT/US2017/027959

申请日：2017-04-17

Applicant: VORTEX BIOSCIENCES, INC.

Inventor： SOLLIER, Elodie ,  KOCHERSPERGER, Michael Lee ,  ENGLERT, Robert F. ,  CHE, James ,  HUANG, Kuo-Wei ,  BOYCE-JACINO, Michael ,  NEDDERSEN, Anastasia ,  PASSERNIG, Anna ,  RICHARDSON, Bruce ,  CHOI, Insang

IPC: G01N1/10 ,  G01N15/14

CPC classification number: B01L3/502761 ,  B01L3/502738 ,  B01L2200/027 ,  B01L2200/0668 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2400/0403 ,  B01L2400/0487 ,  B01L2400/0633 ,  B01L2400/084 ,  G01N1/10 ,  G01N15/1484 ,  G01N35/1097 ,  G01N2015/1006

Abstract: Microfluidic chips and cartridges and systems that include such chips are disclosed. In some embodiments, the chips include a microfluidic channel disposed in a substrate with the channel comprising at least one expansion region. The channel is configured to generate a vortex within the at least one expansion region in response to fluid through the microfluidic channel to trap cells or particles. The substrate in which the channel is formed may be relatively rigid to resist deformation.

Abstract translation: 公开了包括这种芯片的微流体芯片和盒和系统。 在一些实施例中，芯片包括设置在衬底中的微流体通道，该通道包括至少一个扩展区域。 通道被配置成响应于通过微流体通道的流体而在至少一个扩展区域内产生涡流以捕获细胞或颗粒。 其中形成通道的衬底可以相对刚性以抵抗变形。