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    A DEVICE FOR READYING A NEEDLE FREE INJECTOR FOR DELIVERY
    3.
    发明申请
    A DEVICE FOR READYING A NEEDLE FREE INJECTOR FOR DELIVERY 审中-公开

    公开(公告)号：WO2005056077A3

    公开(公告)日：2005-06-23

    申请号：PCT/US2004/040937

    申请日：2004-12-06

    Applicant: ARADIGM CORPORATION ,  BRIDGES, Paul Stuart ,  SCHUSTER, Jeffrey A. ,  GIBBONS, Graham ,  REID, Nicola

    Inventor： BRIDGES, Paul Stuart ,  SCHUSTER, Jeffrey A. ,  GIBBONS, Graham ,  REID, Nicola

    IPC: A61M5/30

    Abstract: A dispensing device, such as a needle free injector, comprising a spring which provides an energy store, and a dispensing member (3) movable to effect dispensing under the force of the spring, a latch (6) having a first, safe position which disables triggering of the device, a second, ready to trigger position in which it restrains movement of the dispensing member but enables triggering, and a third, triggered position in which it permits such movement. A trigger is operable by the user for moving the latch (32) from the second position to the third position. A safety mechanism, preferably in the form of an appropriately shaped slot in the dispensing member, is effective before triggering the device to prevent movement of the latch to the third position. An attachment is provided for moving the latch from the first, safe position to the second, ready to trigger position to enable triggering of the device. A cap (31) is provided to maintain the sterility and stability of the contained medicament, and the device is configured such that it is impossible to place it in the ready to trigger state prior to removal of the cap (31).

    LOCKOUT DEVICE FOR CONTROLLED RELEASE OF DRUG FROM PATIENT-ACTIVATED DISPENSER
    5.
    发明申请
    LOCKOUT DEVICE FOR CONTROLLED RELEASE OF DRUG FROM PATIENT-ACTIVATED DISPENSER 审中-公开
    用于控制从患者激活分配物释放药物的锁定装置

    公开(公告)号：WO1996013293A1

    公开(公告)日：1996-05-09

    申请号：PCT/US1995013912

    申请日：1995-10-27

    Applicant: ARADIGM CORPORATION

    Inventor： ARADIGM CORPORATION ,  RUBSAMEN, Reid, M. ,  LLOYD, Lester, J. ,  JOHANSSON, Eric, T.

    IPC: A61M11/00

    CPC classification number: A61M15/00 ,  A61M11/001 ,  A61M15/0023 ,  A61M15/0045 ,  A61M15/0048 ,  A61M15/0066 ,  A61M15/008 ,  A61M15/0085 ,  A61M15/009 ,  A61M2005/1405 ,  A61M2016/0021 ,  A61M2016/0039 ,  A61M2205/3569 ,  A61M2205/3592 ,  A61M2205/8206

    Abstract: A method of controlling access to a drug in an aerosol drug delivery device by an electronic lock and key means is disclosed. Access is limited to the intended user by providing the intended user with a uniquely coded, machine readable key means that matches the unique code of the lock means. Contacting matching lock and key means signals a controlling means to allow use of the device. Specifically, the method is applied to a method of pain control provided by the intrapulmonary delivery of a pharmaceutically active pain relief formulation. The formulation is automatically released from a hand held, self-contained, portable device (1) comprised of a means to automatically release a measured amount of drug into the inspiratory flow path (11) of a patient in response to information obtained from a means (21) for measuring, and separately determining inspiratory flow rate and inspiratory volume of a patient.

    Abstract translation: 公开了一种通过电子锁和钥匙装置控制气溶胶药物输送装置中药物的获取方法。 通过向目标用户提供与锁定装置的唯一代码匹配的唯一编码的机器可读密钥装置来限制访问。 接触匹配的锁和钥匙装置发出一个控制装置来允许使用该装置。 具体地说，该方法被应用于通过肺内递送药物学活性的疼痛缓解制剂所提供的疼痛控制方法。 该制剂自动从手持式独立的便携式装置（1）中释放出来，该装置包括一种装置，用于响应从装置获得的信息自动释放测量量的药物到患者的吸气流动路径（11） （21），用于测量和分别确定患者的吸气流速和吸气体积。

    INHALED SURFACTANT-MODIFIED LIPOSOMAL FORMULATIONS PROVIDING BOTH AN IMMEDIATE AND SUSTAINED RELEASE PROFILE
    6.
    发明申请
    INHALED SURFACTANT-MODIFIED LIPOSOMAL FORMULATIONS PROVIDING BOTH AN IMMEDIATE AND SUSTAINED RELEASE PROFILE 审中-公开
    补充的表面活性剂修饰的脂质体制剂提供立即和持续的释放特征

    公开(公告)号：WO2015061025A1

    公开(公告)日：2015-04-30

    申请号：PCT/US2014/059092

    申请日：2014-10-03

    Applicant: ARADIGM CORPORATION

    Inventor： CIPOLLA, David ,  GONDA, Igor

    IPC: A61K9/127

    CPC classification number: A61K9/127 ,  A61K9/0078 ,  A61K31/496 ,  A61K47/10 ,  A61K47/26

    Abstract: Methods for formulating and compositions of immediate and sustained release liposomal products which comprise a surfactant that interacts with liposomes to effect drug release therefrom, and delivery of such for treatment of respiratory tract infections and other medical conditions, and devices and formulations used in connection with such are described.

    Abstract translation: 用于配制和立即和持续释放的脂质体产品的组合物的方法，其包含与脂质体相互作用以实现药物释放的表面活性剂，以及用于治疗呼吸道感染和其它医学病症的递送剂，以及与其结合使用的装置和制剂 被描述。

    NICOTINE FORMULATIONS, KITS AND SYSTEMS AND METHODS FOR THEIR USE
    7.
    发明申请
    NICOTINE FORMULATIONS, KITS AND SYSTEMS AND METHODS FOR THEIR USE 审中-公开
    NICOTINE配方，套件及系统及其使用方法

    公开(公告)号：WO2008069970A2

    公开(公告)日：2008-06-12

    申请号：PCT/US2007/024636

    申请日：2007-11-30

    Applicant: ARADIGM CORPORATION ,  GONDA, Igor

    Inventor： GONDA, Igor

    IPC: A61K31/465 ,  A61K9/127 ,  A61P43/00

    CPC classification number: A61K31/465 ,  A61K9/0058 ,  A61K9/008 ,  A61K9/7023

    Abstract: This invention relates generally to formulations, compositions, aerosols and kits used to provide habitual tobacco users with products, methods and apparatus to reduce and eventually terminate their dependence on nicotine containing products. More specifically, the invention relates to a nicotine-based medicament and dosage forms thereof formulated in such a way as to effectively reduce or eliminate the sensations of craving associated with addictive nicotine use.

    Abstract translation: 本发明一般涉及用于向习惯性烟草使用者提供产品，方法和装置以减少并最终终止其对含尼古丁产品的依赖性的制剂，组合物，气溶胶和试剂盒。 更具体地说，本发明涉及一种基于尼古丁的药物及其剂型，以有效地减少或消除与上瘾的尼古丁使用相关的渴望的感觉。

    METHOD TO REDUCE DAMAGE CAUSED BY IRRADIATION OF HALOGENATED POLYMERS
    10.
    发明申请
    METHOD TO REDUCE DAMAGE CAUSED BY IRRADIATION OF HALOGENATED POLYMERS 审中-公开
    降低由卤化聚合物引起的损伤的方法

    公开(公告)号：WO2004072164A2

    公开(公告)日：2004-08-26

    申请号：PCT/US2004/003594

    申请日：2004-02-06

    Applicant: ARADIGM CORPORATION ,  MAUZE, Ganapati ,  TRILOKEKAR, Nikhil

    Inventor： MAUZE, Ganapati ,  TRILOKEKAR, Nikhil

    IPC: C08K

    CPC classification number: B65B55/08 ,  B32B27/08 ,  B65B55/16 ,  C08J3/28 ,  Y10T428/1352 ,  Y10T428/2809 ,  Y10T428/3154

    Abstract: A method for producing a polymeric film resistant to degradation during sterilization such as gamma irradiation is presented. The method includes the steps of minimizing the number of free radicals formed during sterilization through use of an inert gas and a reactant scavenger within a sterilization pouch, which reactant scavenger may be acid adsorbents which scavenge the acid by-products formed during irradiation. The films retain physical and mechanical properties with long-term storage. The films are particularly amenable for use as packaging laminates in pharmaceutical, food, semiconductor and medical device industries.

    Abstract translation: 提出了一种在灭菌过程中耐γ降解的聚合物膜的制造方法，如γ辐射。 该方法包括以下步骤：通过使用消毒袋内的惰性气体和反应物清除剂来最小化在灭菌期间形成的自由基的数量，该反应物清除剂可以是酸性吸附剂，其清除在照射期间形成的酸副产物。 膜具有长期储存的物理和机械性能。 这些电影特别适合用作制药，食品，半导体和医疗器械行业的包装层压材料。

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