利索-全球专利检索

  1. Login
  2. Sign Up

Search Results

353 records (took 0.043 seconds)

    TOPICAL TRPV1 ANTAGONISTS AND METHODS AND COMPOSITIONS THEREOF
    1.
    发明申请
    TOPICAL TRPV1 ANTAGONISTS AND METHODS AND COMPOSITIONS THEREOF 审中-公开
    局部TRPV1拮抗剂及其方法和组合物

    公开(公告)号：WO2018048779A1

    公开(公告)日：2018-03-15

    申请号：PCT/US2017/050032

    申请日：2017-09-05

    Applicant: CHILDREN'S MEDICAL CENTER CORPORATION

    Inventor： WOOLF, Clifford J. ,  YEKKIRALA, Ajay S. ,  COSTIGAN, Michael

    IPC: A61P29/00 ,  A61P25/00 ,  A61K9/00

    CPC classification number: A61P29/00 ,  A61K31/135 ,  A61K31/167 ,  A61K31/196 ,  A61K31/335 ,  A61K31/357 ,  A61K31/4168 ,  A61K38/08 ,  A61K45/06 ,  A61P25/00 ,  A61K2300/00

    Abstract: The technology disclosed herein generally relates to the field of pain relief, and relates to a topical composition comprising a TRPV1 antagonist. The technology disclosed herein provides for methods, compositions and devices for topical application for the treatment of pain, allodynia or hyperalgesia associated with acute tissue injury, e.g., for the treatment of a wounds or tissue injury, including but not limited to incision, abrasion, laceration, puncture and avulsion. The methods, compositions and devices disclosed herein can be used for point-of-care treatment of a tissue injury or wound, e.g., in emergency care for first responders, emergency medical technicians (EMTs), ambulance workers, firemen, in field surgery, combat medicine or casualty care and/or first aid kits.

    Abstract translation: 本文公开的技术通常涉及疼痛缓解领域，并且涉及包含TRPV1拮抗剂的局部用组合物。 本文公开的技术提供用于治疗与急性组织损伤相关的疼痛，异常性疼痛或痛觉过敏的局部应用的方法，组合物和装置，例如用于治疗伤口或组织损伤，包括但不限于切口，磨损， 裂伤，穿刺和撕脱伤。 本文公开的方法，组合物和装置可用于组织损伤或伤口的护理点处理，例如用于紧急护理急救员，紧急医疗技术人员（EMT），救护车工作人员，消防员，野外手术， 打击医疗或伤员护理和/或急救箱。

    USE OF PROSTACYCLIN ANTAGONISTS FOR TREATING OCULAR SURFACE NOCICEPTION
    2.
    发明申请
    USE OF PROSTACYCLIN ANTAGONISTS FOR TREATING OCULAR SURFACE NOCICEPTION 审中-公开
    前列腺环素拮抗剂治疗眼表炎症的应用

    公开(公告)号：WO2017132115A1

    公开(公告)日：2017-08-03

    申请号：PCT/US2017/014677

    申请日：2017-01-24

    Applicant: JENIVISION INC.

    Inventor： WOODWARD, David, Frederick ,  WANG, Weizhen

    IPC: A61P27/02 ,  A61K31/135 ,  A61K31/41 ,  A61K31/4439

    CPC classification number: A61K31/4168 ,  A61K9/0048 ,  A61K9/0051

    Abstract: The present invention relates generally to the compositions and methods for treating nociceptive events or relieving the symptoms associated with those events. The method includes administering an IP antagonist to at least one eye of the patient. The nociceptive events may be associated with the ocular surface, and may be caused by dry eye, ocular surface injury, ulceration, infection, allergy, pollution, or eye surgery.

    Abstract translation: 本发明总体上涉及用于治疗伤害性事件或减轻与这些事件相关的症状的组合物和方法。 该方法包括将IP拮抗剂施用于患者的至少一只眼睛。 伤害性事件可能与眼表相关，并可能由干眼症，眼表损伤，溃疡，感染，过敏，污染或眼部手术引起。

    ASPARAGINE ENDOPEPTIDASE (AEP) INHIBITORS FOR MANAGING CANCER AND COMPOSITIONS RELATED THERETO
    6.
    发明申请
    ASPARAGINE ENDOPEPTIDASE (AEP) INHIBITORS FOR MANAGING CANCER AND COMPOSITIONS RELATED THERETO 审中-公开
    用于管理癌症和组合物的阿伐他汀内肽（AEP）抑制剂

    公开(公告)号：WO2015157376A1

    公开(公告)日：2015-10-15

    申请号：PCT/US2015/024850

    申请日：2015-04-08

    Applicant: EMORY UNIVERSITY

    Inventor： YE, Keqiang ,  FU, Haian ,  DU, Yuhong

    IPC: C07D473/04 ,  C07D473/06 ,  A61K31/52 ,  A61P35/00

    CPC classification number: C07D473/06 ,  A61K31/4015 ,  A61K31/4168 ,  A61K31/433 ,  A61K31/47 ,  A61K31/496 ,  A61K31/519 ,  A61K31/522 ,  A61K31/5355 ,  A61K45/06 ,  C07D207/452 ,  C07D215/06 ,  C07D257/04 ,  C07D273/02 ,  C07D277/54 ,  C07D285/135 ,  C07D471/04

    Abstract: This disclosure relates to asparagine endopeptidase inhibitors for managing cancer and compositions related thereto. In certain embodiments, the asparagine endopeptidase inhibitors are substituted 3,7-dihydropurine-2,6-dione derivatives useful for treating or preventing metastasis, tumor growth, and/or cancer. In certain embodiments, the disclosure relates to pharmaceutical compositions comprising an asparagine endopeptidase inhibitor and a pharmaceutically acceptable excipient. In certain embodiments, the disclosure relates to methods of treating a cancer comprising administering an effective amount of pharmaceutical composition a asparagine endopeptidase inhibitor disclosed herein to a subject in need thereof.

    Abstract translation: 本公开涉及用于管理癌症的天冬酰胺内肽酶抑制剂及其相关的组合物。 在某些实施方案中，天冬酰胺内肽酶抑制剂是用于治疗或预防转移，肿瘤生长和/或癌症的取代的3,7-二氢嘌呤-2,6-二酮衍生物。 在某些实施方案中，本公开涉及包含天冬酰胺内肽酶抑制剂和药学上可接受的赋形剂的药物组合物。 在某些实施方案中，本公开涉及治疗癌症的方法，包括向有需要的受试者施用有效量的本文公开的天冬酰胺内肽酶抑制剂的药物组合物。

    KITS AND METHODS FOR TREATING POST TRAUMATIC STRESS DISORDER ( PTSD) AND HOT FLASHES
    7.
    发明申请
    KITS AND METHODS FOR TREATING POST TRAUMATIC STRESS DISORDER ( PTSD) AND HOT FLASHES 审中-公开
    治疗后紧张症（PTSD）和烫伤的治疗方法

    公开(公告)号：WO2015134133A1

    公开(公告)日：2015-09-11

    申请号：PCT/US2015/013688

    申请日：2015-01-30

    Applicant: LIPOV, Eugene

    Inventor： LIPOV, Eugene

    IPC: A61P25/00 ,  A61K31/445 ,  A61K31/4168

    CPC classification number: A61K31/445 ,  A61K31/167 ,  A61K31/245 ,  A61K31/4168 ,  A61K2300/00

    Abstract: The present invention is directed to kits and methods for the treatment of a patient suffering from post-traumatic stress disorder (PTSD) and/or hot flashes by an administration of a mixture produced by a combination of a long acting local anesthetic combined with clonidine. The combination of the two pharmaceuticals produces a significant increase in duration and speed of onset of sympathetic blockade, increased intensity of the sympathetic blockage as well as the reduction of local anesthetic absorption locally. The combination significantly improves the efficacy, speed of onset and block intensity of a right sided cervical sympathetic ganglion injection (RCSGI) leading to increased length of resolution of PTSD and hot flashes as well as reducing the potential for complications related to absorption of the local anesthetic.

    Abstract translation: 本发明涉及通过施用通过与可乐定组合的长效局部麻醉剂的组合产生的混合物来治疗患有创伤后应激障碍（PTSD）和/或热潮红的患者的试剂盒和方法。 两种药物的组合产生交感神经阻滞的持续时间和速度显着增加，交感神经阻塞的强度增加以及局部麻醉吸收的局部减少。 该组合显着改善右侧颈部交感神经节注射液（RCSGI）的功效，发作速度和阻滞强度，导致PTSD和潮热的分辨率增加，并减少与局部麻醉剂吸收相关的并发症的可能性 。

Patent Agency Ranking