METHOD OF TREATING DISEASE BY AURICULAR ANESTHESIA OF CRANIAL NERVES
    4.
    发明申请
    METHOD OF TREATING DISEASE BY AURICULAR ANESTHESIA OF CRANIAL NERVES 审中-公开
    一种治疗颅内神经麻痹的方法

    公开(公告)号:WO2017079270A1

    公开(公告)日:2017-05-11

    申请号:PCT/US2016/060085

    申请日:2016-11-02

    申请人: CREWS, Thomas M.

    发明人: CREWS, Thomas M.

    摘要: Methods for treating a variety of diseases that comprises performing auricular anesthesia of various cranial nerves. A pharmaceutical composition is administered to an ear canal of a subject in need of such treatment, the composition including an analgesic and/or at least one anesthetic. Compositions useful in the taught methods are also provided.

    摘要翻译: 治疗各种疾病的方法,包括对各种颅神经进行耳麻醉。 将药物组合物施用于需要这种治疗的受试者的耳道,所述组合物包含止痛剂和/或至少一种麻醉剂。 还提供了在所教方法中有用的组合物。

    DEVICES, KITS, AND METHODS FOR DETERMINING INEFFECTIVENESS OF ANESTHETICS
    6.
    发明申请
    DEVICES, KITS, AND METHODS FOR DETERMINING INEFFECTIVENESS OF ANESTHETICS 审中-公开
    用于确定麻醉无效的装置,套件和方法

    公开(公告)号:WO2017035470A1

    公开(公告)日:2017-03-02

    申请号:PCT/US2016/048990

    申请日:2016-08-26

    申请人: ALKALIDX, INC.

    摘要: In general, the invention provides kits, devices, and methods for determining the ineffectiveness of an anesthetic, (e.g., lidocaine), using a topical approach that avoids injection. The methods typically employ the placement of aliquots of two different formulations, at least one including an anesthetic, in different locations on a subject. Further embodiments may employ a single formulation including the anesthetic.

    摘要翻译: 通常,本发明提供了使用避免注射的局部方法来确定麻醉剂(例如,利多卡因)的无效性的试剂盒,装置和方法。 方法通常采用在受试者的不同位置放置两种不同制剂的等分试样,至少一种包括麻醉剂。 其它实施方案可以使用包括麻醉剂的单一制剂。

    A GEL CONTAINING NIFEDIPINE AND LIDOCAINE HYDROCHLORIDE, USE OF SAME AND A METHOD FOR PREPARING SAME USING NANOTECHNOLOGY
    8.
    发明申请
    A GEL CONTAINING NIFEDIPINE AND LIDOCAINE HYDROCHLORIDE, USE OF SAME AND A METHOD FOR PREPARING SAME USING NANOTECHNOLOGY 审中-公开
    一种含尼洛地平和盐酸利多卡因的凝胶及其应用和使用该纳米技术制备该凝胶的方法

    公开(公告)号:WO2016118040A8

    公开(公告)日:2016-10-06

    申请号:PCT/RU2015000034

    申请日:2015-01-21

    摘要: The inventions relate to the pharmaceutical industry, including pharmaceutical compositions forming the base of gels, and methods for producing gels which are intended mainly for preventing and/or treating anal fissures, haemorrhoids and diseases associated therewith and for reducing sensations of pain after a haemorrhoidectomy. The inventions relate to compositions and preparation methods, and also to the use of gels including nifedipine and lidocaine hydrochloride. The gels are prepared using nanotechnology. The technical result is achieved by producing such a composition of a gel including nifedipine and lidocaine hydrochloride, each variant of which provides for robustness of the gel properties, transparency, and preservation of the stability of the properties for up to 2 years, and the use of which makes it possible to reduce the clinical symptoms of haemorrhoids, up to and including complete elimination of said symptoms, to heal an anal fissure, and to relieve pain syndrome, including after a haemorrhoidectomy. Furthermore, the technical result is achieved by creating such a method for preparing a gel including nifedipine and lidocaine hydrochloride using nanotechnology, which provides for robustness of the gel properties, transparency, and preservation of the stability of the properties for up to 2 years. All the proposed inventions are industrially applicable, and laboratory tests have shown that the presented subject matter is practically implementable and will be extensively used in the pharmaceutical industry. 

    摘要翻译: 本发明涉及制药工业,包括形成凝胶基质的药物组合物,以及主要用于预防和/或治疗肛裂,痔疮和与其相关的疾病以及减少痔切除术后疼痛感觉的凝​​胶的生产方法。 本发明涉及组合物和制备方法,还涉及包括硝苯地平和盐酸利多卡因的凝胶的用途。 凝胶是用纳米技术制备的。 通过生产包含硝苯地平和盐酸利多卡因的凝胶组合物来实现技术结果,其每种变体提供凝胶性能的稳健性,透明度和保持该性质的稳定性至多2年,以及用途 其中可以减少痔疮的临床症状,直至并包括完全消除所述症状,治愈肛裂,并且减轻包括痔切除术后的疼痛综合征。 此外,通过使用纳米技术制备包含硝苯地平和盐酸利多卡因的凝胶的这种方法来实现技术结果,该方法提供凝胶性能的稳健性,透明度以及保持该性质的稳定性长达2年。 所有提出的发明在工业上是可应用的,并且实验室测试表明所提出的主题实际上是可实施的并将广泛用于制药工业。