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    CHEMOTACTIC, DRUG-CONTAINING POLYMERSOMES
    2.
    发明申请
    CHEMOTACTIC, DRUG-CONTAINING POLYMERSOMES 审中-公开
    化学疗法，含药物聚合物

    公开(公告)号：WO2017144849A1

    公开(公告)日：2017-08-31

    申请号：PCT/GB2017/050213

    申请日：2017-01-27

    申请人： UCL BUSINESS PLC

    发明人： BATTAGLIA, Giuseppe

    IPC分类号： A61K9/127

    CPC分类号： A61K9/1273

    摘要： The present invention relates to polymersomes that contain an encapsulated drug and that exhibit chemotaxis in response to a chemical stimulus. The chemotactic polymersomes can be targeted in vivo to a location of therapeutic interest with high specificity and selectivity. The present invention also provides related pharmaceutical compositions and therapeutic methods.

    摘要翻译： 本发明涉及聚合物囊泡，其含有包封的药物且对化学刺激具有化学趋化性。 趋化聚合物囊泡可以体内靶向具有高特异性和选择性的治疗目标位置。 本发明还提供了相关的药物组合物和治疗方法。

    TOPICAL COMPOSITION AND DELIVERY SYSTEM AND ITS USE
    3.
    发明申请
    TOPICAL COMPOSITION AND DELIVERY SYSTEM AND ITS USE 审中-公开
    局部组合物和递送系统及其用途

    公开(公告)号：WO2017135948A1

    公开(公告)日：2017-08-10

    申请号：PCT/US2016/016517

    申请日：2016-02-04

    申请人： GREENSPAN, Michael H.

    发明人： GREENSPAN, Michael H.

    IPC分类号： A01N37/12

    CPC分类号： A61K47/20 ,  A61K9/0014 ,  A61K9/127 ,  A61K9/1273 ,  A61K31/00 ,  A61K47/10 ,  A61K47/18

    摘要： The described invention provides a topical delivery system comprising a pharmaceutical composition for application directly to a skin of a subject in need thereof comprising (a) an effective therapeutic amount of an active therapeutic agent; (b) chemical drivers comprising an amino benzoate local anesthetic, ethoxydiglycol and methylsulfonylmethane (MSM) that in combination are effective to synergistically deliver the therapeutic agent; and (c) a depot component for keeping the pharmaceutical composition in the skin. Methods for delivering an active therapeutic agent into skin, for keeping it in the skin, for reducing systemic side effects attributable to entry of the active agent into the blood stream, and a method for treating a condition, disease or disorder of skin topically also are described in accordance with the embodiments of the described invention.

    摘要翻译： 本发明提供包含药物组合物的局部递送系统，所述药物组合物用于直接施用于有需要的受试者的皮肤，所述药物组合物包含（a）有效治疗量的活性治疗剂; （b）包含氨基苯甲酸酯局部麻醉剂，乙氧基二甘醇和甲基磺酰基甲烷（MSM）的化学驱动剂，其组合可有效协同递送治疗剂; 和（c）用于将药物组合物保持在皮肤中的储库组分。 用于将活性治疗剂递送到皮肤中，用于将其保留在皮肤中，用于减少归因于活性剂进入血流中的全身性副作用的方法以及用于局部治疗皮肤状况，疾病或病症的方法也是 根据所述发明的实施例描述。

    LIPOSOME COMPOSITION FOR USE IN PERITONEAL DIALYSIS
    4.
    发明申请
    LIPOSOME COMPOSITION FOR USE IN PERITONEAL DIALYSIS 审中-公开
    用于腹膜透析的脂质体组合物

    公开(公告)号：WO2014023421A1

    公开(公告)日：2014-02-13

    申请号：PCT/EP2013002352

    申请日：2013-08-06

    申请人： ETH ZUERICH

    发明人： LEROUX JEAN-CHRISTOPHE ,  FORSTER VINCENT

    IPC分类号： A61K9/127 ,  A61P7/08

    CPC分类号： A61K9/127 ,  A61K9/1271 ,  A61K9/1272 ,  A61K9/1273 ,  A61M1/287

    摘要： The present invention is directed to a liposome composition for use in the peritoneal dialysis of patients suffering from endogenous or exogenous toxicopathies, wherein the pH within the liposomes differs from the pH in the intraperitoneal cavity and wherein the pH within the liposome results in a liposome-encapsulated charged toxin. The inventtion also relates to a pharmaceutical composition comprising said liposomes. A further aspect of the present invention relates to a method of treating patients suffering from endogenous or exogenous toxicopathies, preferably selected from drug, metabolite, pesticide, insecticide, toxin, and chemical warfare toxicopathies, more preferably hyperammonemia, comprising the step of administering liposomes of the invention in a therapeutically effective amount into the peritoneal space of a patient in need thereof. Next to human, the present invention is particularly suitable to veterinary aspects.

    摘要翻译： 本发明涉及用于患有内源性或外源性毒性病的患者的腹膜透析的脂质体组合物，其中脂质体内的pH与腹膜内腔中的pH不同，并且其中脂质体内的pH导致脂质体 - 封装的带电毒素。 本发明还涉及包含所述脂质体的药物组合物。 本发明的另一方面涉及一种治疗患有内源性或外源性毒性病，优选选自药物，代谢物，杀虫剂，杀虫剂，毒素和化学战毒性病毒，更优选高氨血症的患者的方法，所述方法包括以下步骤： 本发明治疗有效量进入有需要的患者的腹膜空间。 在人类旁边，本发明特别适用于兽医方面。

    METHODS OF TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES AND DISORDERS
    6.
    发明申请
    METHODS OF TREATING INFLAMMATORY AND AUTOIMMUNE DISEASES AND DISORDERS 审中-公开
    治疗炎症和自发性疾病和疾病的方法

    公开(公告)号：WO2013155493A1

    公开(公告)日：2013-10-17

    申请号：PCT/US2013036494

    申请日：2013-04-12

    申请人： UNIV YALE

    发明人： FAHMY TAREK M ,  LOOK MICHAEL ,  CRAFT JOSEPH

    IPC分类号： A61K9/127

    CPC分类号： A61K9/1273 ,  A61K9/1271 ,  A61K9/1277 ,  A61K31/343 ,  A61K38/1841 ,  A61K38/2013 ,  A61K47/24 ,  A61K47/40 ,  A61K47/58 ,  A61K47/6951 ,  B82Y5/00

    摘要： Compositions and methods for treating or ameliorating the symptoms of inflammatory or autoimmune disease or disorder are described herein. The compositions contain a nanolipogel for sustained delivery of an effective amount of one or more active agents of choice, preferably a drug for treating or ameliorating the symptoms of inflammatory or autoimmune disease or disorder. The nanolipogel includes a lipid bilayer surrounding a hydrogel core, which may optionally include a host molecule, for example, an absorbent such as a cyclodextrin or ion-exchange resin. In preferred embodiments at least one of active agents is an immunosuppressant.

    摘要翻译： 本文描述了用于治疗或改善炎性或自身免疫疾病或病症症状的组合物和方法。 所述组合物包含用于持续递送有效量的一种或多种所选择的活性剂，优选用于治疗或改善炎性或自身免疫性疾病或病症症状的药物的纳升磷脂。 纳升虫肽包括围绕水凝胶核心的脂质双层，其可以任选地包括宿主分子，例如吸收剂如环糊精或离子交换树脂。 在优选的实施方案中，至少一种活性剂是免疫抑制剂。

    SUPRAMOLECULAR AGGREGATES CONTAINING AMPHIPHILIC MONOMERS, CHELATING AGENTS AND PEPTIDES FOR USE FOR DRUG DELIVERY AND AS CONTRAST AGENTS
    8.
    发明申请
    SUPRAMOLECULAR AGGREGATES CONTAINING AMPHIPHILIC MONOMERS, CHELATING AGENTS AND PEPTIDES FOR USE FOR DRUG DELIVERY AND AS CONTRAST AGENTS 审中-公开
    包含AMPHIPHILIC单体的SUPRAMOLECULAR聚合体，用于药物输送和作为对照剂的螯合剂和肽

    公开(公告)号：WO2013046163A1

    公开(公告)日：2013-04-04

    申请号：PCT/IB2012/055183

    申请日：2012-09-28

    申请人： INVECTORS S.R.L.

    发明人： ACCARDO, Antonella ,  TESAURO, Diego ,  MORELLI, Giancarlo ,  PEDONE, Carlo ,  DE ROSA, Giuseppe ,  SALZANO, Giuseppina

    IPC分类号： A61K47/48 ,  A61K51/12 ,  A61K9/127

    CPC分类号： A61K9/127 ,  A61K9/1273 ,  A61K31/704 ,  A61K47/6911 ,  A61K51/1234

    摘要： Delivery systems based on liposomes functionalized with peptides and chelating agents, for therapy and imaging by selective targeting of tumour cells expressing the receptors GRP, BBl, BB2, BB3 e BB4 and any other receptor which recognizes the bombesin peptide or analogues thereof are described. In particular, the liposomes contain within them cytotoxic drugs, such as for example doxorubicin, for target-selective antitumour therapy, and, through the presence of the chelating agent, can contain radioactive or paramagnetic ions for the real time visualization of the tumour cells. The liposomes described in this invention thus act as a selective delivery system for drugs and/or contrast agents onto tumour cells expressing the receptors for the class of known peptides such as bombesin (endogenous sequence, analogous or peptidomimetic peptides, agonists or non agonists).

    摘要翻译： 描述了基于用肽和螯合剂官能化的脂质体的递送系统，用于通过选择性靶向表达受体GRP，BB1，BB2，BB3e BB4的肿瘤细胞和识别bombesin肽或其类似物的任何其他受体来进行治疗和成像。 特别地，脂质体包含细胞毒性药物，例如多柔比星，用于靶选择性抗肿瘤治疗，并且通过螯合剂的存在，可以含有放射性或顺磁性离子，用于肿瘤细胞的实时可视化。 因此，本发明中描述的脂质体用作药物和/或造影剂在表达用于已知肽类的受体（例如铃蟾肽（内源序列，类似物或肽模拟肽，激动剂或非激动剂））的选择性递送系统。

    ACOUSTICALLY RESPONSIVE PARTICLES WITH DECREASED CAVITATION THRESHOLD
    9.
    发明申请
    ACOUSTICALLY RESPONSIVE PARTICLES WITH DECREASED CAVITATION THRESHOLD 审中-公开
    具有降低裂隙阈值的有声响应的颗粒

    公开(公告)号：WO2012094541A3

    公开(公告)日：2012-10-04

    申请号：PCT/US2012020389

    申请日：2012-01-05

    申请人： UNIV CALIFORNIA ,  BENCHIMOL MICHAEL ,  ESENER SADIK C ,  SIMBERG DMITRI ,  IBSEN STUART

    发明人： BENCHIMOL MICHAEL ,  ESENER SADIK C ,  SIMBERG DMITRI ,  IBSEN STUART

    IPC分类号： A61K9/16 ,  A61K9/48 ,  A61K47/30 ,  A61K47/48 ,  A61K49/04 ,  A61P35/00

    CPC分类号： A61K41/0047 ,  A61K9/0009 ,  A61K9/1273 ,  A61K41/0028 ,  A61M5/007 ,  A61M37/0092

    摘要： Techniques, systems, devices and materials are disclosed for implementing and fabricating drug delivery and imaging vehicles, which are activated in the body at a tissue of interest by focused ultrasound. In one aspect, a drug delivery vehicle can include a carrier having an outer membrane that envelopes an acoustic sensitizer particle and a payload substance to be delivered to the target tissue. The outer membrane can protect the acoustic sensitizer particle and the payload substance from degradation and opsonization. The outer membrane can be functionalized with a tumor targeting ligand to cause the drug delivery vehicle to selectively accumulate in a tumor region over other tissues, as well as with an agent to increase circulation time by reducing uptake from undesired body tissues, organs, and systems.

    摘要翻译： 公开了用于实施和制造药物递送和成像载体的技术，系统，装置和材料，其通过聚焦超声在感兴趣的组织在体内被激活。 在一个方面，药物递送载体可以包括具有外膜的载体，其包围声敏剂颗粒和有效载体物质被输送到目标组织。 外膜可以保护声学敏化剂颗粒和有效载荷物质免于降解和调理。 外膜可以用肿瘤靶向配体进行功能化，以使药物递送媒介物在其他组织上选择性地积聚在肿瘤区域中，以及通过减少来自不期望的身体组织，器官和系统的摄取而增加循环时间的试剂 。