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    메트포르민 서방성 제제 및 그의 제조방법
    3.
    发明申请
    메트포르민 서방성 제제 및 그의 제조방법 审中-公开
    金属矿的持续释放配方及其制备方法

    公开(公告)号：WO2016060365A1

    公开(公告)日：2016-04-21

    申请号：PCT/KR2015/007526

    申请日：2015-07-21

    Applicant: 씨제이헬스케어 주식회사

    Inventor： 박준홍 ,  이지은 ,  김유정 ,  류춘선 ,  서혁성 ,  오택운 ,  전은경 ,  한성균

    IPC: A61K47/38 ,  A61K47/30 ,  A61K9/22 ,  A61K31/155

    CPC classification number: A61K9/2081 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/2054 ,  A61K9/2095 ,  A61K9/2893 ,  A61K31/155

    Abstract: 본 발명은 인슐린 비의존성 당뇨병 치료제인 메트포르민의 위 체류형 서방성 제제 및 이의 제조방법에 관한 것이다. 보다 구체적으로는 메트포르민 또는 이의 약학적으로 허용가능한 염과 팽윤성 고분자를 포함하는 과립 및 상기 과립 표면에 코팅된 수불용성 고분자 피막을 포함하는 서방출형 과립물을 형성하여 적은 분량의 고분자를 사용하면서도 효과적으로 약물의 방출을 제어할 수 있고, 수화겔을 형성하는 겔화 속도를 조절해주는 초붕해제를 상기 과립물과 함께 혼합하여 제형화함으로써 약물을 포함한 정제가 초기에 빠르게 팽윤될 수 있도록 하는 위 체류형 서방성 제제 및 이의 제조방법에 관한 것이다.

    Abstract translation: 本发明涉及作为非胰岛素依赖性糖尿病药的二甲双胍的保持性持续释放制剂及其制备方法。 更具体地，本发明涉及一种保持性持续释放制剂及其制备方法，其中制备包含二甲双胍或其药学上可接受的盐和可溶胀聚合物的颗粒的缓释颗粒产品， 水不溶性聚合物膜被涂覆在颗粒表面上，因此可以在使用少量聚合物的同时有效地控制药物的释放，并且将颗粒产物与控制凝胶速度的超级蛋白质混合并配制以产生 水凝胶，使得包含药物的片剂可以在早期阶段迅速膨胀。

    METHOD OF MANUFACTURING FINE PARTICLES SUITABLE FOR ORALLY DISINTEGRATING PHARMACEUTICAL DOSAGE FORMS
    6.
    发明申请
    METHOD OF MANUFACTURING FINE PARTICLES SUITABLE FOR ORALLY DISINTEGRATING PHARMACEUTICAL DOSAGE FORMS 审中-公开
    制备适用于口服药物剂型的精细颗粒的方法

    公开(公告)号：WO2015148538A1

    公开(公告)日：2015-10-01

    申请号：PCT/US2015/022289

    申请日：2015-03-24

    Applicant: KASHIV PHARMA, LLC

    Inventor： VAKA, Siva Ram Kiran ,  DESAI, Dipen ,  PHUAPRADIT, Wantanee ,  SHAH, Navnit H. ,  MEGHPARA, Kanji

    IPC: A61K9/20 ,  A61K9/22 ,  A61K9/28 ,  A61K9/32

    CPC classification number: A61K47/32 ,  A61K9/0056 ,  A61K9/146 ,  A61K9/20 ,  A61K9/2081 ,  A61K9/28 ,  A61K9/2893 ,  A61K9/5026 ,  A61K9/5042 ,  A61K9/5073 ,  A61K47/38

    Abstract: Disclosed are methods of making oral pharmaceutical compositions that contain substantially crush resistant drug containing microparticles. The microparticles may contain an active pharmaceutical agent, a polymer and a plasticizer. The microparticles may be uncoated (so as to impart an immediate release profile) or coated so as to impart an extended release (ER), delayed release (DR) or delayed extended release (DER) profile. One or more of the populations of microparticles may be coated with a taste masking composition. The methods may produce oral compositions such as orally disintegrating tablets that contain one or more these types of microparticles in order to further customize the release profile. Also disclosed are the oral compositions, per se, and methods of using same for their intended purposes.

    Abstract translation: 公开了制备含有基本上抗粉碎药物的微粒的口服药物组合物的方法。 微粒可以含有活性药剂，聚合物和增塑剂。 微粒可以是未涂覆的（以便赋予立即释放特征）或被涂覆以赋予延长释放（ER），延迟释放（DR）或延迟释放（DER）延迟释放（DER）轮廓。 一个或多个微粒群可以用掩味组合物包被。 所述方法可以产生口服组合物，例如包含一种或多种这些类型的微粒的口腔崩解片剂，以进一步定制释放曲线。 本发明还公开了口服组合物本身及其预期用途的方法。

    A DELAYED RELEASE DRUG FORMULATION
    7.
    发明申请
    A DELAYED RELEASE DRUG FORMULATION 审中-公开
    延迟释放药物配方

    公开(公告)号：WO2015062640A1

    公开(公告)日：2015-05-07

    申请号：PCT/EP2013/072648

    申请日：2013-10-29

    Applicant: TILLOTTS PHARMA AG

    Inventor： VARUM, Felipe José Oliveira ,  BRAVO GONZÁLEZ, Roberto Carlos ,  BUSER, Thomas ,  BASIT, Abdul Waseh ,  FREIRE, Ana Cristina

    IPC: A61K9/20 ,  A61K9/28 ,  A61K9/24 ,  A61K9/48

    CPC classification number: A61K31/606 ,  A61J3/005 ,  A61K9/0053 ,  A61K9/284 ,  A61K9/2846 ,  A61K9/2866 ,  A61K9/2886 ,  A61K9/2893

    Abstract: In a delayed release formulation comprising a core containing a drug and a delayed release coating for providing intestinal release, release of the drug in the colon is accelerated by including an isolation layer between the core and the delayed release coating. The delayed release coating comprises an inner layer and an outer layer. The outer layer comprises a pH dependently soluble polymeric material which has a pH threshold at about pH 5 or above. The inner layer comprises a soluble polymeric material which is soluble in intestinal fluid or gastrointestinal fluid, said soluble polymeric material being selected from the group consisting of a polycarboxylic acid polymer that is at least partially neutralised, and a non-ionic polymer, provided that, where said soluble polymeric material is a non-ionic polymer, said inner layer comprises at least one additive selected from a buffer agent and a base.

    Abstract translation: 在包含含有药物的核心和用于提供肠释放的延迟释放包衣的延迟释放制剂中，通过在核心和延迟释放包衣之间包括隔离层来加速药物在结肠中的释放。 延迟释放涂层包括内层和外层。 外层包含pH约为5或更高pH值的pH依赖性可溶性聚合材料。 内层包含可溶于肠液或胃肠液的可溶性聚合材料，所述可溶性聚合物材料选自至少部分中和的多元羧酸聚合物和非离子聚合物， 其中所述可溶性聚合物材料是非离子聚合物，所述内层包含至少一种选自缓冲剂和碱的添加剂。

    ROTARY DIE SYSTEM
    8.
    发明申请
    ROTARY DIE SYSTEM 审中-公开
    旋转系统

    公开(公告)号：WO2014190324A3

    公开(公告)日：2015-01-08

    申请号：PCT/US2014039446

    申请日：2014-05-23

    Applicant: BARLEAN S ORGANIC OILS LLC

    Inventor： PUCKETT JOHN

    IPC: A61J3/07 ,  B26F1/08

    CPC classification number: A61J3/005 ,  A61J3/07 ,  A61K9/2072 ,  A61K9/2873 ,  A61K9/2893 ,  A61K9/4825 ,  A61K9/4833 ,  Y10T156/103 ,  Y10T156/1378

    Abstract: A rotary die system that includes first and second axially aligned, coacting rotary dies positioned adjacent one another. Each die includes a working surface having a plurality of recesses defined therein. The recesses in the first die are each configured to align with a recess in the second die to form a product cavity upon coaction of the first and second dies. The product cavity is configured to receive a product. Each recess in at least one of the first or second dies includes a pin therein that is configured to puncture a film that at least partially surrounds the product.

    Abstract translation: 一种旋转模具系统，其包括彼此相邻定位的第一和第二轴向对准的共同作用的旋转模具。 每个模具包括具有限定在其中的多个凹部的工作表面。 第一模具中的凹部各自构造成与第二模具中的凹部对准，以在第一和第二模具的共同作用下形成产品空腔。 产品腔被配置为接收产品。 第一或第二模具中的至少一个模具中的每个凹部包括其中的销，其构造成刺穿至少部分地围绕产品的薄膜。

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