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    A CONTAINER FOR AT LEAST A FIRST INJECTABLE MEDICAMENT AND INJECTION DEVICE
    1.
    发明申请
    A CONTAINER FOR AT LEAST A FIRST INJECTABLE MEDICAMENT AND INJECTION DEVICE 审中-公开

    公开(公告)号：WO2019101672A1

    公开(公告)日：2019-05-31

    申请号：PCT/EP2018/081705

    申请日：2018-11-19

    Applicant: SANOFI

    Inventor： KLEMM, Thomas

    IPC: A61M5/24 ,  A61M5/28 ,  A61M5/315 ,  A61M5/178 ,  A61M5/19

    CPC classification number: A61M5/2459 ,  A61M5/19 ,  A61M5/2425 ,  A61M5/2448 ,  A61M5/286 ,  A61M5/31596 ,  A61M2005/1787 ,  A61M2005/2462

    Abstract: The present disclosure relates to a container (10) for at least a first injectable medicament (60), the container comprising: - an elongated body (11) having a tubular-shaped sidewall (12) extending along a longitudinal axis (z) and having a distal end (13), wherein the elongated body (11) comprises a hollow space (15) with a needle receiving subsection (17) adjacent to the distal end (13), - an outlet (40) at the distal end (13) of the body (11), - a piston (20) arranged inside the elongated body (11), sealingly engaged with the sidewall (12) and slidable along the longitudinal axis (z) relative to the sidewall (12), - a membrane (30) arranged inside the elongated body (11) sealingly engaged with the sidewall (12) and being at least one of slidable and deformable along the longitudinal axis (z) relative to the sidewall (12), - a first cavity (16) confined by the sidewall (12), the outlet (40) and the membrane (30), wherein the first injectable medicament (60) is located in the first cavity (16), - a second cavity (18) confined by the sidewall (12), the piston (20) and the membrane (30), wherein the piston (20) and the membrane (30) are separated from each other by a distance along the longitudinal axis (z), - wherein the outlet (40) is configured to receive or to hold a needle (50) extending from the distal end (13) into the needle receiving subsection (17), and - wherein in an initial configuration, the membrane (30) is located outside the needle receiving subsection (17) and wherein the membrane (30) is displaceable or deformable relative to the sidewall (12) to such an extent that at least a portion (31) of the membrane (30) enters the needle receiving subsection (17).

    MIXING AND INJECTION DEVICE WITH STERILITY FEATURES
    2.
    发明申请
    MIXING AND INJECTION DEVICE WITH STERILITY FEATURES 审中-公开
    具有无菌特性的混合和注射装置

    公开(公告)号：WO2017027876A1

    公开(公告)日：2017-02-16

    申请号：PCT/US2016/047023

    申请日：2016-08-15

    Applicant: WINDGAP MEDICAL, INC

    Inventor： CONSTANTINEAU, Cole ,  STANDLEY, Adam ,  CHAGNON, Jeffrey Thomas

    IPC: A61M5/19 ,  A61M5/20 ,  A61M5/34 ,  A61M5/315

    CPC classification number: A61M5/19 ,  A61J1/1406 ,  A61J1/2096 ,  A61M5/2033 ,  A61M5/2066 ,  A61M5/31596 ,  A61M5/3202 ,  A61M5/3243 ,  A61M5/326 ,  A61M2005/2013 ,  A61M2005/206 ,  A61M2005/2451 ,  A61M2005/247 ,  A61M2005/3118

    Abstract: The present invention relates to a mixing and injector device which can include: a housing having a plurality of separate and distinct chambers disposed therein; one or more displacement mechanisms corresponding to each of the plurality of chambers disposed within the housing; a needle assembly being provided about one of the plurality of chambers, the needle assembly including the following: a septum; a needle being separated from the plurality of chambers by the septum, the needle having a proximal end configured to pierce the septum in an actuated state; and a needle carrier, the needle carrier being configured to translate axially with respect to and toward the septum and pierce the septum and provide fluid communication from the plurality of chambers through the needle in the actuated state.

    Abstract translation: 本发明涉及一种混合和注射器装置，其可以包括：壳体，其具有设置在其中的多个分离且不同的腔室; 一个或多个位移机构对应于设置在壳体内的多个室中的每一个; 针组件围绕所述多个腔室中的一个设置，所述针组件包括：隔膜; 针通过隔膜与多个腔室分离，所述针头具有构造成在致动状态下刺穿隔膜的近端; 和针架，所述针托架被配置为相对于所述隔膜而轴向平移并刺穿所述隔膜，并且在所述致动状态下提供来自所述多个腔室通过所述针头的流体连通。

    DRUG DELIVERY DEVICE
    3.
    发明申请
    DRUG DELIVERY DEVICE 审中-公开
    药物递送装置

    公开(公告)号：WO2016188985A1

    公开(公告)日：2016-12-01

    申请号：PCT/EP2016/061653

    申请日：2016-05-24

    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH

    Inventor： HAYTON, Paul ,  WEST, James ,  COOP, James ,  GILMORE, Stephen Francis

    IPC: A61M5/20 ,  A61M5/315

    CPC classification number: A61M5/31583 ,  A61M5/19 ,  A61M5/2033 ,  A61M5/2066 ,  A61M5/3155 ,  A61M5/31563 ,  A61M5/31585 ,  A61M5/31596

    Abstract: Drug delivery device (1) comprising a housing (4) retaining a primary drug delivery assembly (2) for the delivery of a primary medicament with a primary dose setting member configured to rotate in a helical movement to set a dose of the primary medicament and a secondary drug delivery assembly (3) for the delivery of a secondary medicament. A dose dial (12) is movable between a first position and a second position in axial direction and is rotationally constrained with respect to the housing (4) when moved from the first position into the second position and is rotationally constrained to the primary dose setting member in the second position for setting a dose of the primary medicament. A secondary drive sleeve (16) of the secondary drug delivery assembly (2) serves for dispense of the secondary medicament. The dose dial and the secondary drive sleeve can be coupled for dose setting.

    Abstract translation: 药物输送装置（1）包括保持主药物输送组件（2）的壳体（4），用于递送初级药物，其中主剂量设定构件构造成以螺旋运动旋转以设定初级药物的剂量， 用于递送次级药物的次级药物递送组件（3）。 剂量拨盘（12）可在轴向方向上在第一位置和第二位置之间移动，并且当从第一位置移动到第二位置时相对于壳体（4）旋转地受到约束，并被旋转约束到主剂量设定 第二位置的成员用于设定初级药物的剂量。 辅助药物输送组件（2）的辅助驱动套筒（16）用于分配辅助药剂。 剂量拨盘和辅助驱动套筒可以耦合用于剂量设定。

    CONTAINER FOR MIXING AND DISPENSING TWO COMPONENTS
    5.
    发明申请
    CONTAINER FOR MIXING AND DISPENSING TWO COMPONENTS 审中-公开
    用于混合和分配两个组件的容器

    公开(公告)号：WO2016109336A1

    公开(公告)日：2016-07-07

    申请号：PCT/US2015/067372

    申请日：2015-12-22

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： EGELAND, Marc A. ,  NG, Chin-Yee ,  ETTER, Jo A. ,  KOLAKALURI, Ravi

    IPC: A61M5/20 ,  A61M5/24 ,  A61M5/315

    CPC classification number: A61M5/2448 ,  A61M5/1409 ,  A61M5/2066 ,  A61M5/2459 ,  A61M5/31511 ,  A61M5/31596

    Abstract: A container and methods for storing and mixing a two-component composition is provided. The container includes a body, a first plug and a second plug. The body has a first end, a second end, and a bypass with a length L disposed between the first and second ends. The first and second plugs are slidably disposed in the body and define a first compartment. A second compartment is disposed in the body between the second plug and the second end. The second plug has a first edge, a second edge, and a plurality of spaced-apart primary conduits extending through the second plug. Each primary conduit has a separate first opening. A distance D extends longitudinally from the first edge to the second edge and a distance E extends longitudinally from the first edge to the first opening that is nearest the first edge. D ≥ L and E

    Abstract translation: 提供容器和储存和混合双组分组合物的方法。 容器包括主体，第一插头和第二插头。 主体具有设置在第一和第二端之间的长度为L的第一端，第二端和旁路。 第一和第二插塞可滑动地设置在主体中并限定第一隔间。 第二隔室设置在第二塞子和第二端之间的主体中。 第二塞子具有延伸穿过第二塞子的第一边缘，第二边缘和多个间隔开的主导管。 每个主导管具有单独的第一开口。 距离D从第一边缘纵向延伸到第二边缘，并且距离E从第一边缘纵向延伸到最靠近第一边缘的第一开口。 D≥L和E

    SPRITZE ZUM SEQUENZIELLEN INJIZIEREN VON WIRKSUBSTANZEN
    9.
    发明申请
    SPRITZE ZUM SEQUENZIELLEN INJIZIEREN VON WIRKSUBSTANZEN 审中-公开
    SYRINGE用于活性物质的顺序进样

    公开(公告)号：WO2015071352A1

    公开(公告)日：2015-05-21

    申请号：PCT/EP2014/074472

    申请日：2014-11-13

    Applicant: SFM MEDICAL DEVICES GMBH

    Inventor： HAINDL, Hans ,  KEHR, Markus

    IPC: A61M5/152 ,  A61M5/19 ,  A61M5/28 ,  A61M5/178

    CPC classification number: A61M5/31596 ,  A61M5/19 ,  A61M5/282 ,  A61M5/31511 ,  A61M5/31515 ,  A61M2005/1787

    Abstract: Die Erfindung bezieht sich auf die Verwendung einer Spritze (10) zur Injektion einer Wirksubstanz sowie zum Nachinjizieren eines Mediums, umfassend einen zylindrischen Spritzenkörper (18) mit im distalen Bereich vorhandener vorzugsweise in einen Ansatz (16) übergehender Begrenzungswandung (20), zwei in dem Spritzenkörper axial verschiebbare mechanisch verbundene Kolben (24, 26) und ein erstes Betätigungselement (22) zum gemeinsamen Verschieben der Kolben, wobei vor der Injektion der Wirksubstanz der distale Kolben (26) und die Begrenzungswandung (20) ein mit der Wirksubstanz gefülltes erstes Volumen (41) und die Kolben zwischen einander zugewandten Innenflächen ein mit dem Medium gefülltes zweites Volumen (43) begrenzen, wobei die Kolben bei Kraftbeaufschlagung des ersten Betätigungselementes in Richtung der Begrenzungswandung als mechanisch gekoppelte Einheit bis zum Anliegen des distalen Kolbens an der Begrenzungswandung oder einem Anschlag verstellt werden, anschließend bei weiterer axialer Krafteinleitung auf das erste Betätigungselement die mechanische Verbindung zwischen den Kolben selbsttätig derart verändert wird, dass der proximale Kolben in Richtung des distalen Kolbens verstellt wird, wobei bei Verstellen des proximalen Kolbens zu dem distalen Kolben das Medium den distalen Kolben durchsetzt und/oder an diesem vorbeiströmt.

    Abstract translation: 本发明涉及使用用于活性物质的注入和向一个介质的Nachinjizieren包含圆柱形注射器主体，（18），与现有的在远端区域中，优选在肩连续（16）的限定壁（20），两个在一个注射器（10）的 注射器本体可轴向移动的机械连接的活塞（24，26）和第一致动器（22），用于在活塞的共同位移，一个填充有之前的活性物质的注入到远端活塞（26）和所述边界壁（20）的活性物质的第一体积（ 41）和相互面对的内表面之间的活塞限定了填充有介质第二容积（43），其中所述活塞在所述边界壁作为一个机械耦合单元到所述远端活塞的上边界壁或停止的关注的方向移动在第一致动元件的力的施加 在随后 进一步的轴向力传递自动改变到第一致动器，所述活塞使得近侧活塞在远侧活塞的方向上移位，其中在所述近端活塞到远端活塞的调整，介质经过所述远侧活塞之间的机械连接和/或 这也避开。

    PLUNGER AND PLUNGER VALVE FOR DRUG DELIVERY
    10.
    发明申请
    PLUNGER AND PLUNGER VALVE FOR DRUG DELIVERY 审中-公开
    用于药物递送的冲洗器和排液阀

    公开(公告)号：WO2015031677A1

    公开(公告)日：2015-03-05

    申请号：PCT/US2014/053262

    申请日：2014-08-28

    Applicant: GLUCAGO LLC D/B/A LYOGO

    Inventor： BARTLETT, Rush L. II ,  DAVIGNON, Barry Jay ,  GRECO, Peter M. Jr.

    IPC: A61M5/31

    CPC classification number: A61M5/31513 ,  A61M5/31596 ,  A61M2005/3104 ,  A61M2005/3123

    Abstract: Disclosed herein is a drug delivery device including a container, such as a cartridge or syringe, and a delivery mechanism of one or more plungers or valves which mix and/or administer substances. The container and/or the valves may be lubricated or frictionally varied in various configurations to allow for appropriate glide force during movement of the plungers in the containers. The valves may include a gas seal region or a self-sealing pinhole.

    Abstract translation: 本文公开了一种药物递送装置，其包括容器，例如药筒或注射器，以及混合和/或施用物质的一个或多个柱塞或阀的输送机构。 容器和/或阀可以以各种构造润滑或摩擦地变化，以允许柱塞在容器中移动期间的适当的滑动力。 阀可以包括气体密封区域或自密封针孔。

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